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Chemical Structure| 928324-87-2 Chemical Structure| 928324-87-2

Structure of 928324-87-2

Chemical Structure| 928324-87-2

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Product Details of [ 928324-87-2 ]

CAS No. :928324-87-2
Formula : C12H11NOS
M.W : 217.29
SMILES Code : O=CC1=CNC(C2=CC=CC=C2SC)=C1
MDL No. :MFCD24611538

Safety of [ 928324-87-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 928324-87-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 928324-87-2 ]

[ 928324-87-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 928324-87-2 ]
  • [ 42899-76-3 ]
  • [ 928324-93-0 ]
YieldReaction ConditionsOperation in experiment
69% With 15-crown-5; sodium hydride; In tetrahydrofuran; at 0 - 20℃; for 2h; Reference Example 154 5-[2-(methylthio)phenyl]-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde; To a suspension of sodium hydride (60percent in oil, 40 mg) in tetrahydrofuran (3 mL) were added a solution of 5-[2-(methylthio)phenyl]-1H-pyrrole-3-carbaldehyde (150 mg) in tetrahydrofuran (5 mL), 15-crown-5 (182 mg) and pyridin-3-ylsulfonyl chloride (135 mg) under ice-cooling. After stirring at room temperature for 2 hr, water was added and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=4:1-->2:1) to give the title compound as colorless crystals (yield 170 mg, 69percent). 1H-NMR (CDCl3) delta: 2.05 (3H, s), 6.68 (1H, d, J=2.1 Hz), 6.97-6.99 (1H, m), 7.17-7.31 (3H, m), 7.40-7.45 (1H, m), 7.65-7.70 (1H, m), 8.16 (1H, d, J=2.1 Hz), 8.45-8.46 (1H, m), 8.75-8.77 (1H, m), 9.90 (1H, s).
 

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