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Chemical Structure| 928650-17-3 Chemical Structure| 928650-17-3

Structure of 928650-17-3

Chemical Structure| 928650-17-3

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Product Details of [ 928650-17-3 ]

CAS No. :928650-17-3
Formula : C8H10ClN3
M.W : 183.64
SMILES Code : ClC1=CC(NCC2CC2)=NC=N1
MDL No. :MFCD14611189

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Application In Synthesis of [ 928650-17-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 928650-17-3 ]

[ 928650-17-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 489446-42-6 ]
  • [ 928650-17-3 ]
  • [ 928650-19-5 ]
YieldReaction ConditionsOperation in experiment
38% With potassium carbonate;tetrakis(triphenylphosphine) palladium(0); In ethanol; water; toluene; at 120℃; for 1h;Microwave irradiation; 4-[6-(Cvclopropylmethyl-amino)-pyrimidin-4-yll-iV*-(tert-butoxycarbonyl)-benzylamine; In a microwave reaction vessel, slurry 6-chloro-4-(cyclopropylmethyl-amino)-pyrimidine (560 mg, 3 mmol), [4-(N-tert-butoxycarbonyl-aminomethyl)phenyl]boronic acid (1.1 g, 4 mmol), and tetrakis(triphenylphosphine)palladium(0) (190 mg, 0.15 mmol) in toluene (4 mL). Add ethanol (1 mL) followed by potassium carbonate (0.9 g, 6 mmol) dissolved in water (300 DL). Irradiate in microwave (300 watts) at 120 0C for 60 min. Cool to room temperature, pour reaction mixture into IN NaOH (250 mL) and extract with DCM (3x100 mL). Wash the combined organic extracts with brine, dry over MgSO4, filter and concentrate in vacuo. Purify by chromatography on silica gel (40 g) eluting with hexane/EtOAc (4: 1 to 2:3 over 45 min; 40 mL/min) to obtain the desired intermediate (450 mg, 38%) as a yellow solid. MS (ES+) m/z: 355 (M+H)+.
 

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