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Chemical Structure| 929899-20-7 Chemical Structure| 929899-20-7

Structure of 929899-20-7

Chemical Structure| 929899-20-7

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Product Details of [ 929899-20-7 ]

CAS No. :929899-20-7
Formula : C12H19BN2O4
M.W : 266.10
SMILES Code : O=C(OC)C1N(C)N=C(B2OC(C)(C)C(C)(C)O2)C=1
MDL No. :MFCD16995823
InChI Key :WCOQTWMJQDTQJX-UHFFFAOYSA-N
Pubchem ID :67379260

Safety of [ 929899-20-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 929899-20-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 929899-20-7 ]

[ 929899-20-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 52867-42-2 ]
  • [ 929899-20-7 ]
  • 2
  • [ 929899-20-7 ]
  • [ 98121-41-6 ]
  • methyl 3-(5-amino-3-chloropyridin-2-yl)-1-methyl-1H-pyrazole-5-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
46.5% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 100℃; for 12h;Inert atmosphere; Methyl 1-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-5-carboxylate (1.0 g, 3.76 mmol), <strong>[98121-41-6]5,6-dichloropyridin-3-amine</strong> (0.61 g, 3.76 mmol) and potassium carbonate (1.56 g, 11.3 mmol) were added to dioxane/water (9:1, 20 mL) and the reaction was purged with N2. [1,1'-bis(diphenylphosphino)ferrocene] dichloropalladium (II) (1:1) (0.31 g, 0.38 mmol) was added and the reaction stirred at 100 C. for 12 h. The reaction mixture was filtered, the filtrates were concentrated under reduced pressure to afford a black oil which was purified by flash column chromatography over silica gel (petroleum ether/ethyl acetate from 100/0 to 0/100). The desired fractions were collected and the solvent was concentrated under reduced pressure to afford the product as a black solid (560 mg, 46.5% yield). LC-MS: (ES, m/z): [M+1]+ 267.0
 

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