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Chemical Structure| 932-28-5 Chemical Structure| 932-28-5

Structure of 932-28-5

Chemical Structure| 932-28-5

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Product Details of [ 932-28-5 ]

CAS No. :932-28-5
Formula : C7H11ClO
M.W : 146.61
SMILES Code : O=C(C1CCCC1)CCl
MDL No. :MFCD09955061

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Application In Synthesis of [ 932-28-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 932-28-5 ]

[ 932-28-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 67442-07-3 ]
  • [ 33240-34-5 ]
  • [ 932-28-5 ]
YieldReaction ConditionsOperation in experiment
13.7 g In tetrahydrofuran; at 0 - 20℃; for 1h; 2-Chloro-1-cyclopentylethanone To a solution of <strong>[67442-07-3]2-chloro-N-methoxy-N-methylacetamide</strong> (27 g, 200 mmol) in THF (300 mL) was added 2N cyclopentylmagnesium bromide solution (100 mL, 200 mmol) while maintaining the temperature at 0° C. The reaction was stirred at room temperature for 1 h. After separation, the aqueous layer was extracted with tert-Butyl methyl ether (3*300 mL). The combined organic layer was washed with brine, dried over Na2SO4, and concentrated and the residue was purified by chromatography (dichloromethane/methanol=100/1-20/1) to give the product (13.7 g, 47percent) as a yellow oil. 1H NMR (400 MHz, CDCl3) delta 4.17 (s, 2H), 3.08-3.17 (m, 1H), 1.60-1.90 (m, 8H), LC/MS: m/e=147 (M+H)+.
 

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