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Chemical Structure| 932113-94-5 Chemical Structure| 932113-94-5

Structure of 932113-94-5

Chemical Structure| 932113-94-5

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Product Details of [ 932113-94-5 ]

CAS No. :932113-94-5
Formula : C15H23N5O
M.W : 289.38
SMILES Code : CC1=C(CN)C(NC2CCOCC2)=C3C(N(CC)N=C3)=N1
MDL No. :MFCD31667064

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Application In Synthesis of [ 932113-94-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 932113-94-5 ]

[ 932113-94-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 932113-94-5 ]
  • [ 35700-40-4 ]
  • N-[1-ethyl-6-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2,3-dihydro-1-benzofuran-7-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
The carboxylic acid R'COOH (0.12 mmol) is treated with a solution of HATU (0.12 mmol) in DMF (0.25 ml) and DIPEA (0.052 ml, ca. 0.3 mmol) is added. The solution is shaken for 10 mins, and is treated with a solution of Intermediate 15 or 16 (0.1 mmol) in DMF (0.2 ml). The resulting solution is shaken for 10 mins and left to stand for 18 h (e.g. at room temperature), and then the DMF is removed in a Genevac vacuum centrifuge. The residue is dissolved in chloroform (0.3 ml), is applied to an SPE cartridge (1 g, aminopropyl) which has been pre-washed with chloroform (6 ml), and is eluted sequentially with chloroform (3 ml) and 10% methanol in ethyl acetate (3 ml). Fractions containing the desired product are concentrated in vacuo in a Genevac vacuum centrifuge, and where necessary the residue is purified by mass directed autoprep HPLC (e.g. acetonitrile/water). Where necessary, the compound(s) is/are dissolved in chloroform, and is/are further purified by loading onto a SPE cartridge (0.5 g, aminopropyl) which has been prewashed with chloroform, eluting with 10% methanol in ethyl acetate.
 

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