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Chemical Structure| 934-69-0 Chemical Structure| 934-69-0

Structure of 934-69-0

Chemical Structure| 934-69-0

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Product Details of [ 934-69-0 ]

CAS No. :934-69-0
Formula : C8H12O2
M.W : 140.18
SMILES Code : O=C(C1CCC(CC1)=C)O
MDL No. :MFCD17167321
InChI Key :DENSHBNKGSMOIU-UHFFFAOYSA-N
Pubchem ID :14831547

Safety of [ 934-69-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

Application In Synthesis of [ 934-69-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 934-69-0 ]

[ 934-69-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 145576-28-9 ]
  • [ 934-69-0 ]
YieldReaction ConditionsOperation in experiment
With water; sodium hydroxide; In methanol; at 50℃; for 0.5h; Compound 8-2 (16.1g, 0.096mol) and sodium hydroxide (8g, 0.2mol) were dissolved in a mixed solvent of 100mL of methanol and water (volume ratio 1: 1), reacted at 50C for 0.5h, and rotary evaporated to remove methanol. Then added 200mL of water, and adjusted the pH to acidic, extracted with dichloromethane, washed with saturated brine, and then dried over anhydrous sodium sulfate, the desiccant was removed by filtration, the solvent was removed by rotary evaporation, and concentrated to give a white solid.
3.9 g With water; lithium hydroxide; In tetrahydrofuran; at 20℃; for 12h; Brief procedure: An aqueous solution of LiOH was added to R-2 in THF at room temperature and resulting mixture stirred at room temperature for 12 h. Work up: The reaction mixture was diluted with pentane. The phases were separated and the aqueous layer was acidified with 4 N HCI at ice bath temperature and extracted with diethyl ether. The combined organic extract was dried and concentrated under reduced pressure to furnish the compound R as a solid. Purification: No purification done. TLC system: 30% Ethyl acetate-petroleum ether, Rf value: 0.3 Nature of the compound: White solid, Yield: 3.9 g
0.042 g With methanol; sodium hydroxide; In tetrahydrofuran; at 20℃; for 16h; To a solution of ethyl 4-methylenecyclohexanecarboxylate (0.05 g) in THF (2 mL) and MeOH (0.5 mL) was added 1 N NaOH (1 mL). The resulting solution was stirred at rt for 16 hrs. The reaction mixture was diluted with 1 N HCl and EtOAc. The organic phase was washed with sat. NaCl and dried over anhydrous Na2SO4, filtered and dried to yield Cap N-3 as a yellow oil (0.042 g).1H NMR (400 MHz, CDCl3) delta ppm 4.62-4.73 (2H, m), 2.50 (1H, tt, J=11.01, 3.54 Hz), 2.30-2.41 (2H, m), 1.98-2.14 (4H, m), 1.54-1.69 (2H, m).
0.042 g With methanol; sodium hydroxide; In tetrahydrofuran; at 20℃; for 16h; To a solution of ethyl 4-methylenecyclohexanecarboxylate (0.05 g) in THF (2 mL) and MeOH (0.5 mL) was added 1 N NaOH (1 mL). The resulting solution was stirred at rt for 16 hrs. The reaction mixture was diluted with 1 N HC1 and EtOAc. The organic phase was washed with sat. NaC1 and dried over anhydrous Na2504, filtered and dried to yield Cap N-3 as a yellow oil (0.042 g). ?H NMR (400 MHz,CDC13) ppm 4.62 - 4.73 (2 H, m), 2.50 (1 H, tt, J=1 1.01, 3.54 Hz), 2.30 - 2.41 (2 H, m), 1.98-2.14(4 H, m), 1.54- 1.69(2 H, m).

 

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