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Chemical Structure| 934-94-1 Chemical Structure| 934-94-1

Structure of 934-94-1

Chemical Structure| 934-94-1

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Product Details of [ 934-94-1 ]

CAS No. :934-94-1
Formula : C8H4Br2
M.W : 259.93
SMILES Code : BrC#CC1=CC=C(C=C1)Br
MDL No. :MFCD00480899
Boiling Point : No data available

Safety of [ 934-94-1 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H318-H332
Precautionary Statements:P280-P304+P340+P312-P305+P351+P338+P310

Application In Synthesis of [ 934-94-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 934-94-1 ]

[ 934-94-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 56280-66-1 ]
  • [ 934-94-1 ]
  • [ 13667-12-4 ]
YieldReaction ConditionsOperation in experiment
44% With tetrakis(triphenylphosphine) palladium(0); 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; at 60℃; for 4h;Inert atmosphere; General procedure: Under a dry nitrogen atmosphere, a mixture of Pd(PPh3)4 (5.78mg, 0.005mmol) and DPPE (3.98mg, 0.01mmol) in a reaction vessel was added an (hetero)arylaluminum compound (0.8mmol) in 2mL THF followed by an addition of alkynylbromides (0.50mmol). The resulted solution was stirred at 60C for 4-72h. After completion the reaction, the mixture was diluted with saturated ammonium chloride solution (5mL) and extracted with ethyl acetate (3×15mL). The combined organic layers were dried overanhydrous Na2SO4, filtered and evaporated in vacuum. The residue was subjected to flash column chromatography onsilica gel (hexane or ethyl acetate and hexane) to afford the corresponding 1, 2-disubstituted acetylenes 4
  • 2
  • [ 16635-23-7 ]
  • [ 934-94-1 ]
  • [ 13667-12-4 ]
YieldReaction ConditionsOperation in experiment
68% With bis(triphenylphosphine)nickel(II) chloride; N-ethyl-N,N-diisopropylamine; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; at 60℃; for 0.25h;Inert atmosphere; General procedure: Under a dry nitrogen atmosphere, a mixture of NiCl2(PPh3)2(16.35 mg, 0.025 mmol) and DPPE (29.88 mg, 0.075 mmol) in areaction vessel was added an aryltitanium compound (1.0 mmol) in2 mL THF followed by an addition of alkynylbromides (0.50 mmol).The resulted solution was stirred at 60 C for 15e30 min. Aftercompletion the reaction, the mixture was diluted with saturatedammonium chloride solution (5 mL) and extracted with ethyl acetate(3 15 mL). The combined organic layers were dried overanhydrous Na2SO4, filtered and evaporated in vacuum. The residuewas subjected to flash column chromatography on silica gel (hexaneor ethyl acetate and hexane) to afford the corresponding 1, 2-disubstituted acetylenes 3
 

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