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Chemical Structure| 93594-48-0 Chemical Structure| 93594-48-0

Structure of 93594-48-0

Chemical Structure| 93594-48-0

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Product Details of [ 93594-48-0 ]

CAS No. :93594-48-0
Formula : C22H26FN3O5
M.W : 431.46
SMILES Code : O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CCN(C(OC(C)(C)C)=O)CC4)=C3)C1=O)O

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Application In Synthesis of [ 93594-48-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 93594-48-0 ]

[ 93594-48-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 93107-30-3 ]
  • [ 57260-71-6 ]
  • [ 93594-48-0 ]
YieldReaction ConditionsOperation in experiment
285 mg With potassium carbonate; In N,N-dimethyl-formamide; at 140℃; for 15h; A mixture of compound 1.4 (soo mg, 1.89 mmol, 1 eq), tert-butyl piperazine-1- carboxylate (1.06 g, 5.67 mmol, 3 eq) and potassium carbonate (552 mg, 3.78 mmol, 2 eq) was stirred in DMF (18 mL) at 140°C for 15 hours. Upon completion (as monitored by LC-MS), the mixture was extracted with DCM (2 x 15 mL) and washed with water (10 mL) with the aqueous layer neutralized using a 1M solution of citric acid. Thecombined organic layers were dried over magnesium sulfate and concentrated under reduced pressure. The crude compound was recrystallized from DMF ( mL) to give pure compound 1.5 (285 mg, 35.0 percent yield) as a pale orange solid. JR (umax/cm1) 1729, 1687, 1627, 1502, 1462, 1417, 1383, 1340, 1286, 1246, 1217, 1168,1124, 1083, 1045, 1034, 940, 891, 86, 828, 8o, 782, 770, 746, 703, 667, 625; LC-MSRetention time 3.95 minutes, found 432.0 [M+H] calculated for C22H26FN305 432.46 [M+H]
 

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