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Chemical Structure| 936361-36-3 Chemical Structure| 936361-36-3

Structure of 936361-36-3

Chemical Structure| 936361-36-3

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Product Details of [ 936361-36-3 ]

CAS No. :936361-36-3
Formula : C6H3Br2N3
M.W : 276.92
SMILES Code : BrC1=NC=CN2C1=NC=C2Br
MDL No. :MFCD18072704

Safety of [ 936361-36-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H331
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 936361-36-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 936361-36-3 ]

[ 936361-36-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 143591-61-1 ]
  • [ 936361-36-3 ]
  • [ 3575-32-4 ]
  • [ 887474-76-2 ]
YieldReaction ConditionsOperation in experiment
77% With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 160℃; for 18h; Example 149; The mixed halo-products (3:1 Cl:Br) from Preparative Example 102 (3.67 g, 15.0 mmol), were combined with N,N-dimethyl-m-phenylenediamine.2HCl (4.71 g, 22.5 mmol), i-Pr2NEt (15.7 mL, 90.2 mmol), and NMP solvent (75 mL). The reaction was heated in an oil bath at 160 C. for 18 hours. The reaction was cooled and concentrated under vacuum. The crude material was purified by column chromatography; 2 columns using a gradient of 20% EtOAc/Hexanes increasing to 50% EtOAc/Hexanes. The product 149 was isolated in 95% purity as determined by 1H NMR (400 MHz DMSO-d6,) 9.36 (s, 1H), 7.77 (s, 1H), 7.74 (d, J=4.4 Hz, 1H), 7.54 (d, J=4.8 Hz, 1H), 7.47 (m, 1H), 7.42 (t, J=2.0 Hz), 7.09 (t, J=8.0 Hz, 1H), 6.40 (dd, J=8.0 Hz, 2.0 Hz, 1H), 2.87 (s, 6H). Product was isolated in 77% yield, 3.83 g.
 

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