Alternatived Products of [ 93668-43-0 ]
Product Details of [ 93668-43-0 ]
| CAS No. : | 93668-43-0 |
MDL No. : | MFCD06798214 |
| Formula : |
C5H11Cl2N3
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | ZFRZYBZIYLHQTL-UHFFFAOYSA-N |
| M.W : |
184.07
|
Pubchem ID : | 12377913 |
| Synonyms : |
|
Application In Synthesis of [ 93668-43-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 93668-43-0 ]
- Downstream synthetic route of [ 93668-43-0 ]
- 1
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[ 86-38-4 ]
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[ 93668-43-0 ]
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(6-chloro-2-methoxy-acridin-9-yl)-(2-imidazol-1-yl-ethyl)-amine
[ No CAS ]
- 2
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[ 93668-43-0 ]
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[ 121-60-8 ]
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<i>N</i>-acetyl-sulfanilic acid-(2-imidazol-1-yl-ethylamide)
[ No CAS ]
- 3
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[ 93668-43-0 ]
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[ 154095-02-0 ]
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N-[2-(1H-imidazolyl)ethyl]-4-(2-nitro-1H-imidazolyl)butanamide
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 84% |
|
B. [2-(Imidazol-1-yl)ethyl]-amine, dihydrochloride To a solution of Compound A (600 mg, 2.49 mmol) in methanol (15 mL) was added hydrazine hydrate. The mixture was stirred for 9 hours, the white precipitate was filtered through Celite and the filtrate was concentrated. The residue was dissolved in chloroform (10 mL) and filtered, and the filtrate was extracted with 1N HCl (10 mL). The aqueous layer was concentrated to afford Compound B as a yellow solid (390 mg, 84% yield) which was used without further purification. |
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A mixture of 8.0 g. of 2-[2-(1H-imidazol-1-yl)-ethyl]-isoindole-1,3(2H)-dione, 1.75 ml. of hydrazine hydrate and 120 ml. of ethanol was stirred and refluxed and 3 hours, then cooled and 165 ml. of 10% hydrochloric acid was added. Refluxing was continued for one hour, then the mixture was concentrated to dryness, stirred with 135 ml. of 10% hydrochloric acid and filtered. The aqueous layer was concentrated to dryness, boiled with 170 ml. of ethanol and the white solid collected, giving 4.3 g. of 1H-imidazole-1-ethanamine dihydrochloride. |
- 5
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[ 527-69-5 ]
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[ 93668-43-0 ]
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[ 95082-25-0 ]
| Yield | Reaction Conditions | Operation in experiment |
|
|
In like manner, the reaction of 1H-imidazole-1-ethaneamine dihydrochloride with 2-furoyl chloride by the procedure of Example 1 provided N-[2-(1H-imidazol-1-yl)ethyl]-2-furanecarboxamide, m.p. 131-133 C. |
- 6
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[ 21815-91-8 ]
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[ 93668-43-0 ]
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[ 95059-59-9 ]
| Yield | Reaction Conditions | Operation in experiment |
|
|
A 1.47 g. portion of 1H-imidazole-1-ethanamine dihydrochloride was reacted with 3-chloro-benzo[b]thiophene-2-carbonyl chloride as described in Example 1, giving 0.75 g. of the desired product, m.p. 132-134 C. |
- 7
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[ 13400-67-4 ]
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[ 93668-43-0 ]
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[ 1257259-64-5 ]
- 8
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[ 13400-67-4 ]
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[ 93668-43-0 ]
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[ 1257259-66-7 ]
- 9
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[ 77169-12-1 ]
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[ 93668-43-0 ]
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N-(2-(1H-imidazol-1-yl)ethyl)-1,3-diphenyl-1H-pyrazole-4-carboxamide
[ No CAS ]
- 10
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[ 93668-43-0 ]
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[ 370098-34-3 ]
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N-(2-(1H-imidazol-1-yl)ethyl)-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carboxamide
[ No CAS ]
- 11
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[ 93668-43-0 ]
-
[ 372107-14-7 ]
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N-(2-(1H-imidazol-1-yl)ethyl)-3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-carboxamide
[ No CAS ]
- 12
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[ 93668-43-0 ]
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[ 380910-52-1 ]
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N-(2-(1H-imidazol-1-yl)ethyl)-1-phenyl-3-(p-tolyl)-1H-pyrazole-4-carboxamide
[ No CAS ]
- 13
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[ 93668-43-0 ]
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3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxylic acid
[ No CAS ]
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N-(2-(1H-imidazol-1-yl)ethyl)-3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxamide
[ No CAS ]
- 14
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[ 72459-53-1 ]
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[ 93668-43-0 ]
- 15
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[ 93668-43-0 ]
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1-[(tert-butyloxycarbonylamino)-(tert-butyloxycarbonylimino)-methyl]-1H-pyrazole
[ No CAS ]
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tert-butyl N-[(1Z)-[(tert-butoxy)carbonyl]amino}([2-(1H-imidazol-1-yl)ethyl]amino})methylidene]carbamate
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 71% |
|
To a stirred solution of <strong>[93668-43-0]2-(1H-imidazol-1-yl)ethan-1-amine dihydrochloride</strong> (commercially available from Sigma Aldrich) (600 mg, 3.25 mmol) in DMF (5 mL) was added DIPEA (2.2 mL, 13.0 mmol) at 0 C. After 15 min, tert-butyl N-[(1E)-[(tert-butoxy)carbonyl]amino}(1H-pyrazol-1-yl)methylidene]carbamate (commercially available from Sigma Aldrich) (1.1 g, 3.58 mmol) was added at the same temperature and allowed to stir at RT for 16 h. N2 gas was bubbled into the reaction mixture for 15 minutes then water was added to the crude product followed by stirring for 5 minutes. The resulting precipitate was filtered, washed with water (2 x 10 mL) and dried under high vacuum affording a white solid (800 mg, 71%). M/z 354.2 [M+H]+ |
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