Home Cart Sign in  
Chemical Structure| 936691-30-4 Chemical Structure| 936691-30-4

Structure of 936691-30-4

Chemical Structure| 936691-30-4

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 936691-30-4 ]

CAS No. :936691-30-4
Formula : C12H23NO3
M.W : 229.32
SMILES Code : O=C(OC(C)(C)C)N(C)[C@@H](C(C)C)CC=O
MDL No. :N/A

Safety of [ 936691-30-4 ]

Application In Synthesis of [ 936691-30-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 936691-30-4 ]

[ 936691-30-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 936691-30-4 ]
  • [ 59418-09-6 ]
  • methyl (R)-2-(3-((tert-butoxycarbonyl)(methyl)amino)-4-methylpentanoyl)thiazole-4-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
12% With trimethylsilylazide; bis-[(trifluoroacetoxy)iodo]benzene; In benzene; at 25℃; for 28.5h; Methyl(R)-2-(3-((tert-butoxycarbonyl)(methyl)amino)-4-methylpentanoyl)thiazole-4- carboxylate (3e): To a stirred solution of aldehyde 1 (80 mg, 0.35 mmol) and <strong>[59418-09-6]methyl thiazole-4-carboxylate</strong> 2e (25 mg, 0.17 mmol) in anhydrous benzene (1.0 mL) at 25 C were added portion-wise over 15 min TMSN3 (0.05 mL, 0.35 mmol) followed by phenyliodinebis(trifluoroacetate) (PIFA, 150 mg, 0.35 mmol). After stirring for 16 h at 25 C, TLC analysis indicated complete consumption of aldehyde 1, while unreacted <strong>[59418-09-6]methyl thiazole-4-carboxylate</strong> 2e was still present in the reaction mixture. Consequently, more aldehyde 1 (80 mg, 0.35 mmol), TMSN3 (0.046 mL, 0.35 mmol) and PIFA (150 mg, 0.35 mmol) were added portion-wise over 15 min at 25 C and stirring was continued for an additional 12 h. The reaction mixture was cooled to 0 C and quenched with Et3N (0.2 mL). The solvent was removed under reduced pressure and the resulting residue was purified by flash column chromatography (silica gel, 10?40% EtOAc in hexanes) to produce ketone 3e (7.7 mg, 12% yield) as a colorless oil. 3e: Rf- 0.35 (silica gel, 25% EtOAc in hexanes); [cc]D - 12.0 (c = 1.0, CHCI3); FT-IR (neat) f^,: 2960, 2921, 2851, 1743, 1690, 1460, 1366, 1335, 1248, 1218, 1145, 995, 770 cm 1; NMR: (CDCI3, 600 MHz) delta = 8.42 (d, J = 13.4 Hz, 1H), 4.27 (s, 1H), 3.97 (d, J = 4.3 Hz, 3H), 3.66 - 3.08 (m, 2H), 2.72 (d, J = 1.7 Hz, 3H), 1.88 (dt, J = 16.5, 7.6 Hz, 1H), 1.34 (d, J = 15.0 Hz, 9H), 1.03 (dd, J = 16.7, 6.6 Hz, 3H), 0.89 (dd, J = 6.7, 2.6 Hz, 3H); 13C NMR: (CDCI3, 150 MHz) delta = 192.0, 167.2, 161.2, 155.8, 148.3, 133.4, 79.5, 59.7, 58.8, 52.6, 39.8, 31.1, 28.2, 20.2, 19.6; HRMS calcd for Ci7H26N205S [ +Na+] 393.1460 found 393.1448.
 

Historical Records