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Chemical Structure| 936841-73-5 Chemical Structure| 936841-73-5

Structure of 936841-73-5

Chemical Structure| 936841-73-5

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Product Details of [ 936841-73-5 ]

CAS No. :936841-73-5
Formula : C6H3F4N
M.W : 165.09
SMILES Code : FC1=CN=C(C=C1)C(F)(F)F
MDL No. :MFCD09864698
InChI Key :URVIJEPCSODFNU-UHFFFAOYSA-N
Pubchem ID :26986205

Safety of [ 936841-73-5 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H315-H319-H335
Precautionary Statements:P210-P261-P305+P351+P338
Class:3
UN#:1993
Packing Group:

Application In Synthesis of [ 936841-73-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 936841-73-5 ]

[ 936841-73-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 936841-73-5 ]
  • [ 4522-35-4 ]
  • [ 1621525-08-3 ]
YieldReaction ConditionsOperation in experiment
INTERMEDIATE 15 5-(3-Iodo-lH-pyrazol-l -yl)-2-(trifluorometyl)pyridine To a solution of <strong>[4522-35-4]3-iodopyrazole</strong> (0.588 g, 3.03 mmol) in DMSO (15.0 mL) was added sodium hydride (60% in oil, 0.145 g, 3.64 mmol) and stirred for 0.5 h before 5-fluoro- 2-(trifluoromethyl)pyridines added. The reaction mixture was stirred at 90 C overnight. The reaction was quenched by the addition of water and extracted with EtOAc. The combined organic extracts were washed with water and brine, dried over MgS04 and concentrated in vacuo. The crude mixture was purified by passing through the silica gel funnel with CH2C12 to give 5-(3-iodo-lH-pyrazol-l -yl)-2- (trifiuorometyl)pyridine, as a yellow solid. LCMS calc. = 339.95; found = 339.89 (M+H)+. 1H NMR (500 MHz, CDC13): delta 9.03 (d, J= 2.3 Hz, 1 H); 8.24 (dd, J= 8.4, 2.1 Hz, 1 H); 7.86 (d, J= 2.5 Hz, 1 H); 7.80 (d, J= 8.5 Hz, 1 H); 6.73 (d, J = 2.6 Hz, 1 H).
  • 2
  • [ 936841-73-5 ]
  • [ 913839-73-3 ]
 

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