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Chemical Structure| 94193-77-8 Chemical Structure| 94193-77-8

Structure of 94193-77-8

Chemical Structure| 94193-77-8

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Product Details of [ 94193-77-8 ]

CAS No. :94193-77-8
Formula : C10H12ClNO2
M.W : 213.66
SMILES Code : O=C(N[C@H](C1=CC=CC=C1)CO)CCl

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Application In Synthesis of [ 94193-77-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 94193-77-8 ]

[ 94193-77-8 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 94193-77-8 ]
  • [ 1260672-03-4 ]
YieldReaction ConditionsOperation in experiment
2.25 g With sodium hydride In tetrahydrofuran at 0 - 20℃; The crude 2-chloro-N-(2-hydroxy-l-phenylethyl)acetamide (3 g, 14.04 mmol) was dissolved in of dry THF (40 mL) and the mixture was cooled to about 0 °C. NaH (0.842 g, 35.1 mmol) was added in 2 portions and the reaction was warmed to rt. The reaction was quenched by the slow addition of a 50percent solution of THF/water, diluted into EtOAc, washed with aq NaHC03, water, and brine. The organics were collected and purified by flash chromatography (30-100percent EtO Ac/heptane) to give the title compound (2.25 g, 90percent); LC/MS (Table 1, Method f) Rt = 0.39 min; MS m/z: 219(M+H+MeCN)+
References: [1] Patent: WO2016/168641, 2016, A1, . Location in patent: Page/Page column 145; 146.
 

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