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Chemical Structure| 942261-75-8 Chemical Structure| 942261-75-8

Structure of 942261-75-8

Chemical Structure| 942261-75-8

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Product Details of [ 942261-75-8 ]

CAS No. :942261-75-8
Formula : C14H10N2O
M.W : 222.24
SMILES Code : O=C(C1=CC=CC=C1)C2=CC=C3C(NC=C3)=N2
MDL No. :MFCD23703454

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Application In Synthesis of [ 942261-75-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 942261-75-8 ]

[ 942261-75-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 100-58-3 ]
  • [ 189882-33-5 ]
  • [ 942261-75-8 ]
YieldReaction ConditionsOperation in experiment
Step A: Phenyl(1H-pyrrolo[2,3-b]pyridin-6-yl)methanone In a round-bottomed flask under argon, 25.2 ml of 1M phenylmagnesium bromide in tetrahydrofuran are dissolved in 7 ml of anhydrous tetrahydrofuran. In another round-bottomed flask under argon, 0.6 g of <strong>[189882-33-5]1H-pyrrolo[2,3-b]pyridine-6-carbonitrile</strong> and 1.07 ml of trimethylsilyl chloride are dissolved in 7 ml of tetrahydrofuran. That solution is then pipetted onto the magnesium solution at ambient temperature. After stirring for one night, the mixture is hydrolyzed with 20 ml of 2N ammonium chloride solution. The pH is then adjusted to 1 using 10% hydrochloric acid and the solution obtained is stirred for 2 hours at ambient temperature. The pH of the solution is adjusted to 9 using concentrated ammonium hydroxide solution and the aqueous phase is extracted twice with 20 ml of dichloromethane. The organic phases are dried over magnesium sulphate, filtered and evaporated under reduced pressure. After purification by chromatography on silica gel (pure dichloromethane and then dichloromethane/methanol:99/1), the title compound is obtained in the form of a yellow solid. Melting point: 174 C.
 

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