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Chemical Structure| 943026-55-9 Chemical Structure| 943026-55-9

Structure of 943026-55-9

Chemical Structure| 943026-55-9

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Product Details of [ 943026-55-9 ]

CAS No. :943026-55-9
Formula : C10H11NO
M.W : 161.20
SMILES Code : NCC1=CC=C(OCC#C)C=C1
MDL No. :MFCD12802758

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Application In Synthesis of [ 943026-55-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 943026-55-9 ]

[ 943026-55-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 943026-55-9 ]
  • [ 14615-72-6 ]
  • C31H29NO3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
83% A solution of 8 (1.90 g,5.97 mmol) and 7 (1.36 g, 8.45 mmol) in dry MeOH (120 mL) washeated under reux until completion of the aldehyde (monitoredby 1H NMR). The reaction mixture was then cooled to 0 8C, and thenNaBH4 (2.26 g, 59.7 mmol) was added in several portionscautiously. The resulting solution was warmed to room tempera-ture gradually and then stirred overnight before being concentrat-ed under reduced pressure. The residue was dissolved in CH2Cl2(150 mL), washed with H2O (2 50 mL) and brine (50 mL), theorganic phase was dried over anhydrous Na2SO4 and ltered. Thesolvent was then removed to provide a yellow viscous oil, whichwas puried by silica-gel column chromatography (CH2Cl2/CH3OH,100:1, v/v) to afford 6 as a colorless viscous oil (2.30 g, 83%). 1HNMR (300 MHz, CDCl3, 298 K): d 7.46-7.29 (m, 10H), 7.25 (d, 2H,J = 8.7 Hz), 6.93 (d, 2H, J = 8.7 Hz), 6.61 (d, 2H, J = 2.2 Hz), 6.52 (t,1H, J = 2.2 Hz), 5.03 (s, 4H), 4.68 (d, 2H, J = 2.4 Hz), 3.73 (s, 2H), 3.72 (s, 2H), 2.51 (t, 1H, J = 2.4 Hz); 13C NMR (75 MHz, CDCl3, 298 K): d160.2, 156.7, 143.1, 137.1, 133.5, 129.5, 128.7, 128.1, 127.7, 114.9,107.3, 100.8, 78.9, 75.7, 70.1, 55.9, 53.2, 52.5; LR-ESI-MS: m/z calcd.for [M+H]+ C31H30NO3+, 464.22, found 464.20.
 

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