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Quality Control of [ 944238-89-5 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 944238-89-5 ]

Product Details of [ 944238-89-5 ]

CAS No. :	944238-89-5	MDL No. :	MFCD09997870
Formula :	C₁₁H₂₀N₂O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	RBLOMFQUEUBEBG-IUCAKERBSA-N
M.W :	212.29	Pubchem ID :	45789463
Synonyms :

Safety of [ 944238-89-5 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 944238-89-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 944238-89-5 ]

[ 944238-89-5 ] Synthesis Path-Downstream 1~17

1
[ 944238-89-5 ]
C₂₁H₃₃BN₄O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: potassium carbonate / acetonitrile / 1 h / 150 °C 2: potassium acetate; palladium diacetate / N,N-dimethyl-formamide / 16 h / 85 °C / Inert atmosphere

Reference： [1]Scott, James S.; Birch, Alan M.; Brocklehurst, Katy J.; Broo, Anders; Brown, Hayley S.; Butlin, Roger J.; Clarke, David S.; Davidsson, Öjvind; Ertan, Anne; Goldberg, Kristin; Groombridge, Sam D.; Hudson, Julian A.; Laber, David; Leach, Andrew G.; MacFaul, Philip A.; McKerrecher, Darren; Pickup, Adrian; Schofield, Paul; Svensson, Per H.; Sörme, Pernilla; Teague, Joanne [Journal of Medicinal Chemistry, 2012, vol. 55, # 11, p. 5361 - 5379]

2
[ 944238-89-5 ]
[ 1272972-77-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: potassium carbonate / acetonitrile / 1 h / 150 °C 2: potassium acetate; palladium diacetate / N,N-dimethyl-formamide / 16 h / 85 °C / Inert atmosphere 3: sodium peroxoborate tetrahydrate / tetrahydrofuran; water / 16 h / 25 °C 4: caesium carbonate / N,N-dimethyl-formamide / 2 h / 40 °C

3
[ 944238-89-5 ]
[ 1272973-66-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: potassium carbonate / acetonitrile / 1 h / 150 °C 2: potassium acetate; palladium diacetate / N,N-dimethyl-formamide / 16 h / 85 °C / Inert atmosphere 3: sodium peroxoborate tetrahydrate / tetrahydrofuran; water / 16 h / 25 °C

4
[ 944238-89-5 ]
[ 32779-36-5 ]
[ 1272973-76-8 ]

Yield	Reaction Conditions	Operation in experiment
90%	With potassium carbonate In acetonitrile at 150℃; for 1h;

5
[ 944238-89-5 ]
[ 108-23-6 ]
(1S,4S)-2-tert-butyl 5-isopropyl 2,5-diazabicyclo[2,2,1]heptane-2,5-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1.3 g	With N-ethyl-N,N-diisopropylamine In ethyl acetate; toluene for 0.166667h;	5.6.154.A Part A. (1S.4Sl-2-tert-Butyl 5-isopropyl 2.5-diazabicyclo[2.2.1Jheptane-2.5-dicarboxylate To a stirred, ambient temperature, solution (1S,4S)-tert-butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate [113451-59-5] (1.0 g, 5.0 mmol) and Hunig's base [7087-68-5] (1.4 ml, 8.0 mmol) inethyl acetate (120 ml) was slowly added a 1.0M solution of isopropyl chloroformate in toluene (5.120 ml) over the course of 10 minutes. The reaction was allowed to stir over night then was washed withbrine, dried (MgS04), and evaporated to obtain 1.3 g of yellow oil. LRMS (ESI) mjz 285.1 [(M+H)]+,calc'd for C14H24N204: 284.35.

Reference： [1]Current Patent Assignee: LEXICON PHARMACEUTICALS INC - WO2013/134219, 2013, A1 Location in patent: Page/Page column 137

6
[ 944238-89-5 ]
(1S,4S)-isopropyl 2,5-diazabicyclo[2,2,1]heptane-2-carboxylate hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / toluene; ethyl acetate / 0.17 h 2: hydrogenchloride / methanol / 2 h / 50 °C

Reference： [1]Current Patent Assignee: LEXICON PHARMACEUTICALS INC - WO2013/134219, 2013, A1

7
4,11-dihydroxy-3-[(dimethylamino)methyl]-1H-naphtho[2,3-f]indole-5,10-dione iodomethylate [ No CAS ]
[ 944238-89-5 ]
3-(((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)-4,11-dihydroxy-1H-naphtho[2,3-f]indole-5,10-dione dihydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: chloroform / 1 h / Reflux 2: hydrogenchloride / methanol; chloroform

Reference： [1]Shchekotikhin, Andrey E.; Glazunova, Valeria A.; Dezhenkova, Lyubov G.; Luzikov, Yuri N.; Buyanov, Vladimir N.; Treshalina, Helena M.; Lesnaya, Nina A.; Romanenko, Vladimir I.; Kaluzhny, Dmitry N.; Balzarini, Jan; Agama, Keli; Pommier, Yves; Shtil, Alexander A.; Preobrazhenskaya, Maria N. [European Journal of Medicinal Chemistry, 2014, vol. 86, p. 797 - 805]

8
4,11-dihydroxy-3-[(dimethylamino)methyl]-1H-naphtho[2,3-f]indole-5,10-dione iodomethylate [ No CAS ]
[ 944238-89-5 ]
C₂₈H₂₉N₃O₆*2ClH [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In chloroform for 1h; Reflux;	4.1.3. (S)-4,11-Dihydroxy-3-((pyrrolidin-3-ylamino)methyl)-1Hnaphtho[2,3-f]indole-5,10-dione dihydrochloride (6) General procedure: A stirring solution of iodomethylate 5 (100 mg, 0.2 mmol) and(S)-1-Boc-3-aminopyrrolidine (100 mg, 2.5 mmol) in chloroform (10 mL) was refluxed for 1 h. The mixture was diluted with chloroform (25 mL), washed with water and aqueous solution of NaHCO3 (1%), dried, and evaporated. The residue was purified by column chromatography on silica gel in chloroform-methanol(2:0→2:1). The red solid obtained after evaporation was dissolved in hot chloroform (1 mL), and a solution of HCl in methanol (1.25 N,1 mL) was added. The mixture was stirred overnight and evaporated.The residue was dissolved in hot water (0.5 mL), filtered and then product was precipitated with acetone-ether mixture (1:1),collected by filtration and dried. The yield of dihydrochloride 6 was 58 mg (61%) as a red solid, mp 212-213°C (dec.).

9
[ 591-50-4 ]
[ 944238-89-5 ]
tert-butyl (1S,4S)-5-phenyl-2,5-diazabicyclo[2.2.2]octane-2-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
0.6 g	With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium <i>tert</i>-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene	310.A Example 310. Synthesis of (1R,4R)-2-((6-methoxy-2,3-dihydro-1H-inden-1-yl)methyl)-5- phenyl-2,5-diazabicyclo[2.2.2]octane A. To a solution of (1S,4S)-tert-butyl 2,5-diazabicyclo[2.2.2]octane-2-carboxylate (500 mg, 2.36 mmol) in PhMe (30 mL) was added iodobenzene (1.44 g, 7.08 mmol),potassium 2- methylpropan-2-olate (0.79 g, 7.08 mmol) and Pd2(dba)3 (0.22 g, 0.24 mmol), BINAP (0.29 g, 0.47 mmol). The reaction were filtered and concentrated in vacuo. The resulting oil was purified by flash column chromatography with EtOAc (30%) and hexanes (70%) to provide (1S,4S)-tert-butyl 5- phenyl-2,5-diazabicyclo[2.2.2]octane-2-carboxylate (0.6 g, 2.08 mmol) as a yellow oil.

Reference： [1]Current Patent Assignee: SUMITOMO CHEMICAL COMPANY LIMITED; Sumitomo Chemical (w/o Dongwoo Fine-Chem); Sumitomo Pharma (in: Sumitomo Chemical) - WO2018/26371, 2018, A1 Location in patent: Paragraph 0318

10
[ 944238-89-5 ]
(1R,4R)-2-((6-methoxy-2,3-dihydro-1H-inden-1-yl)methyl)-5-phenyl-2,5-diazabicyclo[2.2.2]octane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: potassium <i>tert</i>-butylate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene 2: hydrogenchloride / tetrahydrofuran; water / 2 h / 20 °C 3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 20 °C 4: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

Reference： [1]Current Patent Assignee: SUMITOMO CHEMICAL COMPANY LIMITED; Sumitomo Chemical (w/o Dongwoo Fine-Chem); Sumitomo Pharma (in: Sumitomo Chemical) - WO2018/26371, 2018, A1

11
[ 944238-89-5 ]
(1S,4S)-2-phenyl-2,5-diazabicyclo[2.2.2]octane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: potassium <i>tert</i>-butylate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene 2: hydrogenchloride / tetrahydrofuran; water / 2 h / 20 °C

Reference： [1]Current Patent Assignee: SUMITOMO CHEMICAL COMPANY LIMITED; Sumitomo Chemical (w/o Dongwoo Fine-Chem); Sumitomo Pharma (in: Sumitomo Chemical) - WO2018/26371, 2018, A1

12
[ 944238-89-5 ]
(6-methoxy-2,3-dihydro-1H-inden-1-yl)((1S,4S)-5-phenyl-2,5-diazabicyclo[2.2.2]octan-2-yl)methanone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: potassium <i>tert</i>-butylate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene 2: hydrogenchloride / tetrahydrofuran; water / 2 h / 20 °C 3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 20 °C

Reference： [1]Current Patent Assignee: SUMITOMO CHEMICAL COMPANY LIMITED; Sumitomo Chemical (w/o Dongwoo Fine-Chem); Sumitomo Pharma (in: Sumitomo Chemical) - WO2018/26371, 2018, A1

13
[ 3934-20-1 ]
[ 944238-89-5 ]
tert-butyl (1S,4S)-5-(2-chloropyrimidin-4-yl)-2,5-diazabicyclo[2.2.2]octane-2-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
47%	With triethylamine In 1,4-dioxane at 50℃; for 3h;

Reference： [1]Fensome, Andrew; Ambler, Catherine M.; Arnold, Eric; Banker, Mary Ellen; Brown, Matthew F.; Chrencik, Jill; Clark, James D.; Dowty, Martin E.; Efremov, Ivan V.; Flick, Andrew; Gerstenberger, Brian S.; Gopalsamy, Ariamala; Hayward, Matthew M.; Hegen, Martin; Hollingshead, Brett D.; Jussif, Jason; Knafels, John D.; Limburg, David C.; Lin, David; Lin, Tsung H.; Pierce, Betsy S.; Saiah, Eddine; Sharma, Raman; Symanowicz, Peter T.; Telliez, Jean-Baptiste; Trujillo, John I.; Vajdos, Felix F.; Vincent, Fabien; Wan, Zhao-Kui; Xing, Li; Yang, Xiaojing; Yang, Xin; Zhang, Liying [Journal of Medicinal Chemistry, 2018, vol. 61, # 19, p. 8597 - 8612]

14
[ 944238-89-5 ]
tert-butyl (1S,4S)-5-(2-((4-(ethylcarbamoyl)phenyl)amino)pyrimidin-4-yl)-2,5-diazabicyclo[2.2.2]octane-2-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: triethylamine / 1,4-dioxane / 3 h / 50 °C 2: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 4 h / 100 °C

15
[ 944238-89-5 ]
4-((4-((1S,4S)-5-(cyclopropanecarbonyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)pyrimidin-2-yl)amino)-N-ethylbenzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: triethylamine / 1,4-dioxane / 3 h / 50 °C 2.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 4 h / 100 °C 3.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C 3.2: 4 h

16
[ 944238-89-5 ]
5-(5-(4-(2-bromoethoxy)-3-ethylphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile [ No CAS ]
tert-butyl (1S,4S)-5-(2-(4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-ethylphenoxy)ethyl)-2,5-diazabicyclo[2.2.2]octane-2-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
84%	With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 60℃; for 18h;	43 tert- Butyl (lS,4S)-5-(2-(4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo- 6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-ethylphenoxy)ethyl)-2,5- diazabicyclo [2.2.2] octane-2-carboxylate. To a solution of ter/-butyl (lS,4S)-2,5- diazabicyclo[2.2.2]octane-2-carboxylate (0.057 g, 0.27 mmol, 1.2 eq) in DMF (2.26 mL, 0.100 M) was added 5-[5-[4-(2-bromoethoxy)-3-ethyl-phenyl]-8-oxo-6-thioxo-5,7- diazaspiro[3.4]octan-7-yl]-3-(trifluoromethyl)pyridine-2-carbonitrile (0.125 g, 0.23 mmol, 1 eq), (prepared as described herein), and DIEA (0.14 mL, 0.79 mmol, 3.5 eq). The mixture was heated to 60 °C, while stirring for 18 h. After concentration under reduced pressure, the reaction mixture was purified by silica gel column chromatography (0-100% hexane/EtOAc) to give tert- butyl (lS,4S)-5-(2-(4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7- diazaspiro[3.4]octan-5-yl)-2-ethylphenoxy)ethyl)-2,5-diazabicyclo[2.2.2]octane-2-carboxylate (0.130 g, 0.19 mmol, 84.0% yield) as a beige solid. MS (ESI) m/z 685.2 [M+l]+.

Reference： [1]Current Patent Assignee: BRISTOL-MYERS SQUIBB CO - WO2020/132014, 2020, A1 Location in patent: Paragraph 00551

17
[ 944238-89-5 ]
2-[4-(4-chlorophenyl)-5-(pyridin-4-yl)-1H-imidazol-1-yl]acetic acid 2,2,2-trifluoroacetic acid [ No CAS ]
tert-butyl (1S,4S)-5-{2-[4-(4-chlorophenyl)-5-(pyridin-4-yl)-1H-imidazol-1-yl]acetyl}-2,5-diazabicyclo[2.2.2]octane-2-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
70 mg	With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate at 20℃; for 1h;	1.8 Synthesis of tert-butyl (1S,4S)-5-{2-[4-(4-chlorophenyl)-5-(pyridin-4-yl)-1H-imidazol-1-yl]acetyl}- 2,5-diazabicyclo[2.2.2]octane-2-carboxylate / Intermediate 66 2-[4-(4-Chlorophenyl)-5-(4- pyridyl)imidazol-1-yl]acetic acid;2,2,2-trifluoroacetic acid (Intermediate 2a) (75 mg, 0.137 mmol) and tert-butyl (1S,4S)-2,5-diazabicyclo[2.2.2]octane-2-carboxylate (30 mg, 0.141 mmol) were dissolved in a solution of EtOAc (1.5 mL) and DIPEA (120 uL, 0.687 mmol), then T3P (50%, 165 uL, 0.277 mmol) was added. The reaction was stirred at RT for 1 h. The reaction mixture was diluted with EtOAc and partitioned with water. The organic phase was separated and the aqueous was extracted with DCM/MeOH (9:1). The combined organics were concentrated in vacuo. The crude product was purified via flash chromatography (10 g, silica) eluting with 0-10% 2M ammonia MeOH/DCM to afford the title compound (70 mg, 95% yield) as a yellow solid.1HNMR(400 MHz, DMSO-d6) δ 8.66 - 8.61 (m, 2H), 7.81 - 7.79 (m, 1H), 7.41 - 7.37 (m, 2H), 7.31 - 7.25 (m, 4H), 4.95 - 4.79 (m, 1H), 4.77 - 4.72 (m, 1H), 4.46 - 3.99 (m, 2H), 3.58 - 3.38 (m, 2H), 3.38 - 3.25 (m, 2H), 1.89 - 1.78 (m, 1H), 1.74 - 1.64 (m, 3H), 1.43 (s, 9H). LCMS (Analytical Method H) Rt = 0.55 min, MS (ESIpos): m/z 508.3, 510.3 [M+H]+, Purity = 95%

Reference： [1]Current Patent Assignee: FACIO INTELLECTUAL PROPERTY - WO2021/105474, 2021, A1 Location in patent: Page/Page column 109; 119

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P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 944238-89-5 ] {[proInfo.proName]}

Quality Control of [ 944238-89-5 ]

Related Doc. of [ 944238-89-5 ]

Product Details of [ 944238-89-5 ]

Safety of [ 944238-89-5 ]

Application In Synthesis of [ 944238-89-5 ]

[ 944238-89-5 ] Synthesis Path-Downstream 1~17

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry