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Chemical Structure| 947771-07-5 Chemical Structure| 947771-07-5

Structure of 947771-07-5

Chemical Structure| 947771-07-5

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Product Details of [ 947771-07-5 ]

CAS No. :947771-07-5
Formula : C5H4N2O
M.W : 108.10
SMILES Code : N#CCC1=CN=CO1
MDL No. :MFCD11101412

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Application In Synthesis of [ 947771-07-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 947771-07-5 ]

[ 947771-07-5 ] Synthesis Path-Downstream   1~2

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YieldReaction ConditionsOperation in experiment
In N,N-dimethyl-formamide; at 20 - 70℃; for 4.0h;Inert atmosphere; [000284j Synthesis of 2-(oxazol-5-yl) acetonitrile (345): To a stirred solution of compound 344 (700 mg, 5.95 mmol) in DMF (8 mL) under argon atmosphere was added sodium cyanide (1.02 g, 20.85 mmol) at RT; heated to 70 C and stirred for 4 h. The reaction was monitored by TLC; after completion of the reaction, the reaction mixture was diluted with water (20 mL) and extracted with ether (2 x 20 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to obtain the crude compound 345 (650 mg) as colorless syrup. TLC: 40% EtOAc/ hexanes (R 0.3); 1H-NMR (CDC13, 400 MHz): oe 7.89 (s, 1H), 7.10 (s, 1H), 3.84 (s, 2H).
 

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