Home Cart Sign in  
Chemical Structure| 94994-16-8 Chemical Structure| 94994-16-8

Structure of 94994-16-8

Chemical Structure| 94994-16-8

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 94994-16-8 ]

CAS No. :94994-16-8
Formula : C9H15FO
M.W : 158.21
SMILES Code : OCC1(CC2)CCC2(F)CC1
MDL No. :MFCD30803209

Safety of [ 94994-16-8 ]

Application In Synthesis of [ 94994-16-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 94994-16-8 ]

[ 94994-16-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1354961-13-9 ]
  • [ 94994-16-8 ]
  • tert-butyl 5-chloro-2-fluoro-4-((4-fluorobicyclo[2.2.2]octan-1-yl)methoxy)benzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
61% With caesium carbonate; In dimethyl sulfoxide; at 80℃; A suspension or -fluorobicycio[2.2.2]octan-1-y1)methano1 (0.180 g, 1.14 rnmol), <strong>[1354961-13-9]tert-butyl 5-chloro-2,4-difluorobenzoate</strong> (0.296 g, 1.19 mmol) and cesium carbonate (0.743 g, 2.28 mmol) in anhydrous dimethyl sulfoxide (4 mL) was heated at 80 C and stirred overnight. The solution was quenched with IN aqueous hydrochloric acid (10 mE) and diluted with saturated aqueousammonium chloride (50 mL) and ethyl acetate (150 mL). The aqueous layer was separated and extracted with ethyl acetate (3 x 100 mL). The combined organic layers were then washed with brine (100 mE), dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified using flash chromatography eluting with gradient 0% to 5% of ethyl acetate in hexanes to afford the title compound as a colorless gum (0.27 g, 61 %): ‘H NMR (300 MHz,CDC13)6 7.87 (d,J= 7.6 Hz, 1H), 6.57 (d,J= 12.1 Hz, 1H), 3.62 (s, 2H), 1.94-1.78 (m, 12H),1.57 (s, 9H).
 

Historical Records