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Chemical Structure| 950577-05-6 Chemical Structure| 950577-05-6

Structure of 950577-05-6

Chemical Structure| 950577-05-6

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Product Details of [ 950577-05-6 ]

CAS No. :950577-05-6
Formula : C9H7BrN2O2
M.W : 255.07
SMILES Code : O=C1NC=NC2=C1C=C(Br)C(OC)=C2

Safety of [ 950577-05-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 950577-05-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 950577-05-6 ]

[ 950577-05-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 169045-04-9 ]
  • [ 3473-63-0 ]
  • [ 950577-05-6 ]
YieldReaction ConditionsOperation in experiment
71% In ethanol; for 24.0h;Heating / reflux; 6-bromo-7-methoxyquinazoline-4(3H)-one <strong>[169045-04-9]2-amino-5-bromo-4-methoxybenzoic acid</strong> (type T) (5.63 g, 23 mmol) was dissolved in EtOH (100 mL), formamidine acetate (4.76 g, 46 mmol) added and refluxed for 1 d. Water (200 mL) was then added, the precipitated product filtered out and washed with 70% ethanol. (Yield: 4.14 g, 71%)
  • 2
  • [ 290-87-9 ]
  • [ 169045-04-9 ]
  • [ 950577-05-6 ]
YieldReaction ConditionsOperation in experiment
63% With piperidine; In methanol; for 1.0h;Heating / reflux; 6-Bromo-7-methoxy-3H-quinazolin-4-one 2-Amino-5-bromo-4-methoxybenzoic acid (1.56 g, 6.34 mmol) is dissolved in methanol (15 ml), treated with piperidine (0.063 ml, 0.63 mmol) and 1,3,5-triazine (772 mg, 9.5 mmol) and refluxed for one hour. After cooling to room temperature, the resulting crystals are filtered off with suction and washed with methanol. The desired product is obtained in 63% yield (1.01 g). 1H-NMR (300 MHz, DMSO-d6): delta 3.95 (s, 3H), 7.20 (s, 1H), 8.08 (s, 1H), 8.16 (s, 1H), 12.2 (br, 1H).
 

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