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Chemical Structure| 954224-40-9 Chemical Structure| 954224-40-9

Structure of 954224-40-9

Chemical Structure| 954224-40-9

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Product Details of [ 954224-40-9 ]

CAS No. :954224-40-9
Formula : C10H5Cl3N2
M.W : 259.52
SMILES Code : ClC1=CC=C(C2=CC(Cl)=NC=N2)C=C1Cl
MDL No. :MFCD09861837

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Application In Synthesis of [ 954224-40-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 954224-40-9 ]

[ 954224-40-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 5918-93-4 ]
  • [ 954224-40-9 ]
  • [ 1319157-21-5 ]
YieldReaction ConditionsOperation in experiment
With sodium hydride; In N,N-dimethyl-formamide; at 90℃; for 0.0833333h;Microwave irradiation; Referring to Reaction Scheme 15, Stage 1, to a solution of 4-chloro-6-(3,4- dichloro-phenyl)-pyrimidine (leq) in DMF (20vol) was added sodium hydride (1.5eq) and imidazolone (1.5eq). The reaction mixture was heated at 90°C in a microwave for 5 minutes. To the cool mixture were added dichloromethane and a saturated solution of NaHCCb. The organic layer was separated and the aqueous layer was extracted further with dichloromethane. The organic layers were combined, dried with Na2S04, filtered and evaporated to dryness. Purification by flash column chromatography and trituration using an adequate solvent afforded the target compound.
  • 2
  • [ 39799-77-4 ]
  • [ 954224-40-9 ]
  • [ 1319157-21-5 ]
 

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