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Chemical Structure| 954226-60-9 Chemical Structure| 954226-60-9

Structure of 954226-60-9

Chemical Structure| 954226-60-9

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Product Details of [ 954226-60-9 ]

CAS No. :954226-60-9
Formula : C8H8N2O
M.W : 148.16
SMILES Code : O=CC1=CN=C(C2CC2)N=C1
MDL No. :MFCD09863195
InChI Key :MESDALXDBSNYMH-UHFFFAOYSA-N
Pubchem ID :24903623

Safety of [ 954226-60-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 954226-60-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 954226-60-9 ]

[ 954226-60-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2009-81-6 ]
  • [ 57297-29-7 ]
  • [ 954226-60-9 ]
YieldReaction ConditionsOperation in experiment
53.5% With sodium hydroxide; In water; acetonitrile; at 0 - 20℃; To a mixture of a1 (ca. 0.095 mol) in CH3CN (300 mL) was added <strong>[57297-29-7]cyclopropanecarboximidamide hydrochloride</strong> (12.5 g, 0.105 mol), then sodium hydroxide (7.6 g, 0.19 mol) in water (7.6 mL) was added drop-wise at 0° C. After addition was complete, the resulting mixture was stirred at room temperature overnight. After filtration, the filtrate was concentrated to remove CH3CN under reduced pressure and the residue water phase was extracted with DCM (3×300 mL). The organic layer was dried over Na2SO4, filtered and concentrated in vacuum to give a red oil, which was purified by column chromatography on silica gel (petroleum ether:EtOAc=2:1) to afford 2-cyclopropylpyrimidine-5-carbaldehyde (7.6 g, yield: 53.5percent). 1H NMR (CDCl3 400 MHz): delta 10.06 (s, 1H), 8.99 (s, 2H), 2.41-2.35 (m, 1H), 1.32-1.21 (m, 4H).
 

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