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Chemical Structure| 954271-22-8 Chemical Structure| 954271-22-8

Structure of 954271-22-8

Chemical Structure| 954271-22-8

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Product Details of [ 954271-22-8 ]

CAS No. :954271-22-8
Formula : C13H13NO3S
M.W : 263.31
SMILES Code : O=S(C1=CC=CC(OCC2=CC=CC=C2)=C1)(N)=O
MDL No. :MFCD21601419

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Application In Synthesis of [ 954271-22-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 954271-22-8 ]

[ 954271-22-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 954271-22-8 ]
  • [ 159622-10-3 ]
  • [ 954271-28-4 ]
YieldReaction ConditionsOperation in experiment
A solution of 0.7 g of (\\R,2S)-\\ -ter^butoxycarbonylamino-2-vinyl- cyclopropanecarboxylic acid (prepared as described in Journal of Organic Chemistry, 2005, 5869-5879) in THF (10 mL) is treated with carbonyldiimidazole (0.789 g) and the reaction mixture is stirred at 65 0C for 30 min. The mixture is allowed to cool to RT and 3-benzyloxy- benzenesulfonamide (1.05 g) and DBU (0.697 ml) are added. The solution is stirred at RT for <n="96"/>12 h. The reaction mixture is taken up in EtOAc, washed with 0.1N aqueous HCl, aqueous NaHCOa and brine, dried with Na2SO4 and concentrated. The residue is chromatographed on SiO2 gel (eluent hexanes/EtOAc 7:3 to EtOAc, then EtOAc/MeOH 9:1) to give [(l/?,2S)-l-(3- benzylpxy-benzenesulfonylaminocarbonyl)-2-vinyl-cyclopropyl]-carbamic acid terf-butyl ester. API-MS: M+l = 473. .
 

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