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Chemical Structure| 955406-30-1 Chemical Structure| 955406-30-1

Structure of 955406-30-1

Chemical Structure| 955406-30-1

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Product Details of [ 955406-30-1 ]

CAS No. :955406-30-1
Formula : C12H12BrF2NO
M.W : 304.13
SMILES Code : FC1(F)CCN(C(C2=CC=C(Br)C=C2)=O)CC1

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Application In Synthesis of [ 955406-30-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 955406-30-1 ]

[ 955406-30-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 721960-43-6 ]
  • [ 955406-30-1 ]
  • (4’-amino-3‘-chlorobiphenyl-4-yl)(4,4-difluoropiperidin-1-yl)methanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 100℃; for 18h; A mixture of 2-chloro-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)aniline (30) (7.59 g, 30 mmol), (4-bromophenyl)(4,4-difluoropiperidin-l-yl)methanone (10 g, 33 mmol), Pd(dppf)Cl2 (2 g, 2.4 mmol) and K2C03 (8.3 g, 60 mmol) in dioxane (120 mL) and water (12 mL) was degassed and heated at 100 C for 18 h. After cooling to room temperature the reaction mixture was filtered. The filtrate was concentrated under reduced pressure and purified by silica gel chromatography (0-50% EtOAc/petroleum ether) to give 6.6 g of (4'-amino-3'- chlorobiphenyl-4-yl)(4,4-difluoropiperidin-l-yl)methanone (31) (75% yield). LCMS: m/z 351.1 [M+H]+, tR = 1.86 min.
 

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