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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 957205-24-2 Chemical Structure| 957205-24-2

Structure of 957205-24-2

Chemical Structure| 957205-24-2

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Product Citations

Product Citations

Zore, Matej ; San-Martin-Galindo, Paola ; Reigada, Ines ; Hanski, Leena ; Fallarero, Adyary ; Yli-Kauhaluoma, Jari , et al.

Abstract: The emergence of multidrug-resistant bacteria along with a declining pipeline of clinically useful antibiotics has led to the urgent need for the development of more effective agents. Inspired by our recent report on the activity of , an immunomodulating drug candidate, we prepared a series of derivatives by varying substituents on the phenyl ring, altering the central tricyclic aromatic ring, and modifying the carboxyl group. From this series of compounds, derivative 24f was identified as the most potent compound, with the minimum inhibitory concentration (MIC) values between 2.5 and 10 μM against various Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), S. epidermidis and enterococci. Moreover, 24f exhibited rapid bactericidal activity against S. aureus, low toxicity and hemolytic activity, and a synergistic effect with gentamicin against S. aureus, MRSA, and Enterococcus faecalis. Furthermore, it was shown that neither nor 24f affects S. aureus cell membranes. Importantly, 24f did not induce resistance in S. aureus, representing a significant improvement compared to . Finally, the activity of and 24f against S. aureus and MRSA was confirmed in vivo in a Caenorhabditis elegans infection model. Taken together, our study highlights the value of and its derivatives as potential candidates for combating infections caused by Gram-positive bacteria.

Keywords: activity ; Derivatives ; ; MRSA ; Staphylococcus aureus

Alternative Products

Product Details of [ 957205-24-2 ]

CAS No. :957205-24-2
Formula : C14H16ClF3
M.W : 276.73
SMILES Code : FC(C1=CC(CCl)=CC=C1C2CCCCC2)(F)F

Safety of [ 957205-24-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H318
Precautionary Statements:P280-P301+P312+P330-P305+P351+P338+P310
Class:8
UN#:3261
Packing Group:
 

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