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Chemical Structure| 96304-06-2 Chemical Structure| 96304-06-2

Structure of 96304-06-2

Chemical Structure| 96304-06-2

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Product Details of [ 96304-06-2 ]

CAS No. :96304-06-2
Formula : C7H15NO2
M.W : 145.20
SMILES Code : COC[C@H]1NC[C@H](OC)C1
MDL No. :MFCD19220141

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Application In Synthesis of [ 96304-06-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 96304-06-2 ]

[ 96304-06-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 132898-96-5 ]
  • [ 96304-06-2 ]
  • [ 1445167-01-0 ]
YieldReaction ConditionsOperation in experiment
267 mg With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; chloroform; at 20℃; for 1h; General procedure: To a stirred solution of the N-Boc-protected pyrrolidine (1.0 mmol) in dry DCM (3 mL) at 0 C under argon atmosphere, TFA (1.14 g, 10.0 mmol) was added dropwise. The obtained solution was stirred at 0 C for 30 min followed by stirring at r.t. for 2 h. Subsequently, the solution was poured to cold 10% aq. NaOH (15 mL) and extracted with DCM (3 × 15 mL). The combined organic phases were dried over MgSO4 and concentrated under reduced pressure resulting in the corresponding unprotected pyrrolidine, which was used in the next step without further purification. The free pyrrolidine (ca. 1 mmol) from the previous step was then taken up in CHCl3 (2.2 mL) and DIPEA (2.0 mmol) was added. The solution was added dropwise to a stirred solution of 5-chlorosulfonyl isatin (1.5 mmol) in CHCl3/THF (1:1, 15 mL) at room temperature. The resulting mixture was stirred further for 1 h and the solvent was removed under reduced pressure. After purification by flash column chromatography the target isatin sulfonamide was obtained.
 

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