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Chemical Structure| 96604-34-1 Chemical Structure| 96604-34-1

Structure of 96604-34-1

Chemical Structure| 96604-34-1

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Product Details of [ 96604-34-1 ]

CAS No. :96604-34-1
Formula : C13H14F3NO
M.W : 257.26
SMILES Code : C/C(N(C)C)=C\C(C1=CC=CC(C(F)(F)F)=C1)=O
MDL No. :MFCD07021390

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Application In Synthesis of [ 96604-34-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 96604-34-1 ]

[ 96604-34-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 96604-34-1 ]
  • [ 1450-93-7 ]
  • 7-methyl-5-[3-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrimidine [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium acetate; In hexane; acetic acid; EXAMPLE 13 7-Methyl-5-[3-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrimidine A mixture of 5.14 g of (3-dimethylamino)-1[3-(trifluoromethyl)phenyl]-2-butene-1-one, 1.64 g of anhydrous sodium acetate and 2.64 g of <strong>[1450-93-7]2-aminoimidazole hemisulfate</strong> in 100 ml of glacial acetic acid was refluxed for six hours. The solvent was removed in vacuo and the solid residue was partitioned between a saturated aqueous sodium bicarbonate solution and dichloromethane. The organic layer was separated and dried over powdered anhydrous sodium sulfate, then passed through a short column of a hydrous magnesium silicate. The effluent was refluxed on a steam bath with the gradual addition of hexane until crystallization was noted. On cooling the product was separated and collected by filtration and gave 2.55 g of the desired compound as off-white crystals, m.p. 170°-172° C.
 

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