Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 98-28-2 | MDL No. : | MFCD00019992 |
Formula : | C10H13ClO | Boiling Point : | 238.7°C at 760 mmHg |
Linear Structure Formula : | - | InChI Key : | N/A |
M.W : | 184.66 g/mol | Pubchem ID : | - |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
![]() |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With formaldehyd |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; iron(III) chloride |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With magnesium; benzene |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sulfuric acid; acetic acid |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride Erwaermen des Reaktionsprodukts mit 2,4-Dichlor-phenol und AlCl3 in Tetrachloraethen; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; acetic acid |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With iron(III) chloride at 140℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | With methanol; sulfuryl dichloride In dichloromethane Ambient temperature; | |
95% | With SO2Cl2 In methanol; dichloromethane; water | 7 4-tert-butyl-2-chloro-phenol Example 7 4-tert-butyl-2-chloro-phenol To a solution of 4-tert-butyl-phenol (40.0 g, 0.27 mol) and SO2Cl2 (37.5 g, 0.28 mol) in CH2Cl2 was added MeOH (9.0 g, 0.28 mol) at 0° C. After addition was complete, the mixture was stirred overnight at room temperature and then water (200 mL) was added. The resulting solution was extracted with ethyl acetate. The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated under vacuum. The residue was purified by column chromatography (Pet. Ether/EtOAc, 50:1) to give 4-tert-butyl-2-chloro-phenol (47.0 g, 95%). |
95% | With sulfuryl dichloride In methanol; dichloromethane at 0 - 20℃; | 7 4-tert-butyl-2-chloro-phenol To a solution of 4-tert-butyl-phenol (40.0 g, 0.27 mol) and SO2Cl2 (37.5 g, 0.28 mol) in CH2Cl2 was added MeOH (9.0 g, 0.28 mol) at 0° C. After addition was complete, the mixture was stirred overnight at room temperature and then water (200 mL) was added. The resulting solution was extracted with ethyl acetate. The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated under vacuum. The residue was purified by column chromatography (Pet. Ether/EtOAc, 50:1) to give 4-tert-butyl-2-chlorophenol (47.0 g, 95%). |
88% | With 2,4,6-tris[(4-dichloroiodo)phenoxy]-1,3,5-triazine In acetonitrile at 20℃; for 2h; | General Procedure for Nuclear Chlorination of Arenes General procedure: Reagent 8 (0.5 mmol) was added to a stirred solution of the appropiate activated arene (1 mmol) in CH2Cl2 (3 mL). The reaction mixture was stirred at r.t. for the period of timegiven in Table 1, and progress of reaction was monitored byTLC. When the substrate was consumed, the CH2Cl2 was evaporated under reduced pressure. MeOH was added to the reaction mass, and the white precipitate was isolated by filtration. The residue was washed several times with small aliquote of MeOH and air-dried to recover 2,4,6-tris(4-iodophenoxy)-1,3,5-triazine in 93% yield. The filtrate was concentrated in vacuo to afford the crude product which was purified by column chromatography on silica gel using PE-EtOAc (9:1) as eluent to give the chlorinated product in excellent purity. |
83% | With chloro-trimethyl-silane; bis-[(trifluoroacetoxy)iodo]benzene In dichloromethane at 20℃; for 18h; Inert atmosphere; | |
at 65 - 85℃; Einleiten von Chlor; | ||
With sulfuryl dichloride In tetrachloromethane | ||
With diisobutylamine; sulfuryl dichloride | ||
With diisobutylamine; sulfuryl dichloride In toluene at 25℃; for 2h; | ||
With sulfuryl dichloride In chloroform | 1.a EXAMPLE 1 (a) To a stirred solution of 27.6 g. of 4-tert. butylphenol in 225 ml. of chloroform is added dropwise at 0 degrees C., 26.82 g. of sulfuryl chloride. The yellow solution is kept overnight at 5 degrees C. and the solvent and excess reagent are then removed in vacuo. The residue is distilled under reduced pressure to produce 27.2 g. of 4-tert.butyl-2-chlorophenol, b.p. 85-90 degrees C./1 mmHg. | |
With sulfuryl dichloride In dichloromethane | 30.1.1 (Step 1-1) (Step 1-1) Synthesis of 2-chloro-4-t-butylphenol: 4-t-Butylphenol (2.76 g, 18.4 mmol) was dissolved in dichloromethane (25 ml). Sulfuryl chloride (1.6 ml, 9.9 mmol) was added dropwise to the obtained solution, and they were stirred at room temperature for 3 days and then concentrated under reduced pressure. After the purification by the silica gel column chromatography, 2-chloro-4-t-butylphenol (yield: 2.71 g, 80 %) was obtained. 1H-NMR(300MHz, CDCl3) δ =1.28(9H, s), 5.37(1H, s), 6.94(1H, d, J=8.6Hz), 7.19(1H, dd, J=8.6Hz, 2.5Hz), 7.30(1H, d, J=2.5Hz). | |
95 %Spectr. | With (Dichloroiodo)benzene In acetonitrile at 20℃; for 8h; | |
33 %Chromat. | With copper dichloride In acetic acid at 80℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; acetic acid |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hexamethylenetetramine; boric acid; glycerol at 150 - 165℃; und Behandeln des Reaktionsgemisches mit wss.H2SO4 unter Durchleiten von Wasserdampf; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium chloride; phosphorus trichloride | ||
With magnesium chloride; phosphorus trichloride |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With copper(l) chloride; magnesium chloride; trichlorophosphate | ||
Multi-step reaction with 2 steps 1: MgCl2; PCl3 2: sulfur; PCl3 / Edukt 4: Thiophosphorsaeure-<i>O</i>-<4-<i>tert</i>-butyl-2-chlor-phenylester>-dichlorid |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With magnesium; benzene |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide; water at 107 - 110℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; iron(III) chloride | ||
With trichlorophosphate |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With trichlorophosphate |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide at 150℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With Fuller's Earth at 150℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With pyridine In benzene |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With pyridine In toluene |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
(i) aq. NaOH, (ii) /BRN= 2082144/, THF; Multistep reaction; | ||
With sodium hydroxide In tetrahydrofuran |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine In benzene |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine In benzene |
[ 5323-65-9 ]
2-Chloro-4-(tert-pentyl)phenol
Similarity: 0.92
[ 75908-77-9 ]
2,6-Dichloro-4-(tert-pentyl)phenol
Similarity: 0.90
[ 5323-65-9 ]
2-Chloro-4-(tert-pentyl)phenol
Similarity: 0.92
[ 75908-77-9 ]
2,6-Dichloro-4-(tert-pentyl)phenol
Similarity: 0.90