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[ CAS No. 98205-73-3 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 98205-73-3
Chemical Structure| 98205-73-3
Structure of 98205-73-3 * Storage: {[proInfo.prStorage]}
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Product Details of [ 98205-73-3 ]

CAS No. :98205-73-3 MDL No. :
Formula : C12H16N2O Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 204.27 Pubchem ID :-
Synonyms :

Safety of [ 98205-73-3 ]

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Application In Synthesis of [ 98205-73-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 98205-73-3 ]

[ 98205-73-3 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 821-48-7 ]
  • [ 13414-56-7 ]
  • [ 98205-73-3 ]
  • 3
  • [ 608-33-3 ]
  • [ 98205-73-3 ]
  • 4
  • [ 206347-30-0 ]
  • [ 98205-73-3 ]
  • 5
  • [ 110-85-0 ]
  • [ 206347-30-0 ]
  • [ 98205-73-3 ]
YieldReaction ConditionsOperation in experiment
With sodium t-butanolate;tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 117℃; for 6h; 1-(2,3-Dihydrobenzofuran-7-yl)piperazine (C7i); In detail, for the synthesis of compound C7i 2,6-dibromophenole (29 mmol) (C8a; R4-R6 = H) is mixed with 1,2-dibromoethane (29 mmol) (r = 1) unter basic aqueous conditions (NaOH) and heated at reflux for 18 hrs. The resulting monoalkylation product can be solved in THF/hexane (4/1), cooled to -80 C and then, a solution of 2,5 M butyllithium (18mmol) in hexane is added dropwise (17.1 mmol). The cyclisation product <strong>[206347-30-0]7-bromo-2,3-dihydrobenzofuran</strong>e (4 mmol) (C8b; r = 1) can be suspended together with NaOtBu (20 mmol), Pd2(dba)3 (2 mol%), BINAP (2 mol%) and piperazine (8 mmol) in 5 ml dry toluene and heated at 117C for 6 hrs to get the product.
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