Alternatived Products of [ 98205-73-3 ]
Product Details of [ 98205-73-3 ]
CAS No. : | 98205-73-3 |
MDL No. : | |
Formula : |
C12H16N2O
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
204.27
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 98205-73-3 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 98205-73-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 98205-73-3 ]
- 1
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[ 821-48-7 ]
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[ 13414-56-7 ]
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[ 98205-73-3 ]
- 2
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[ 35700-40-4 ]
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[ 98205-73-3 ]
- 3
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[ 608-33-3 ]
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[ 98205-73-3 ]
- 4
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[ 206347-30-0 ]
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[ 98205-73-3 ]
- 5
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[ 110-85-0 ]
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[ 206347-30-0 ]
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[ 98205-73-3 ]
Yield | Reaction Conditions | Operation in experiment |
|
With sodium t-butanolate;tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 117℃; for 6h; |
1-(2,3-Dihydrobenzofuran-7-yl)piperazine (C7i); In detail, for the synthesis of compound C7i 2,6-dibromophenole (29 mmol) (C8a; R4-R6 = H) is mixed with 1,2-dibromoethane (29 mmol) (r = 1) unter basic aqueous conditions (NaOH) and heated at reflux for 18 hrs. The resulting monoalkylation product can be solved in THF/hexane (4/1), cooled to -80 C and then, a solution of 2,5 M butyllithium (18mmol) in hexane is added dropwise (17.1 mmol). The cyclisation product <strong>[206347-30-0]7-bromo-2,3-dihydrobenzofuran</strong>e (4 mmol) (C8b; r = 1) can be suspended together with NaOtBu (20 mmol), Pd2(dba)3 (2 mol%), BINAP (2 mol%) and piperazine (8 mmol) in 5 ml dry toluene and heated at 117C for 6 hrs to get the product. |