[ CAS No. 206347-30-0 ] {[proInfo.proName]}

Name: 206347-30-0|7-Bromo-2,3-dihydrobenzofuran|98%
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SKU: A206773
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Quality Control of [ 206347-30-0 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Details of [ 206347-30-0 ]

CAS No. :	206347-30-0	MDL No. :	MFCD09266210
Formula :	C₈H₇BrO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	VGOUXHRZQNPOPY-UHFFFAOYSA-N
M.W :	199.05	Pubchem ID :	22571869
Synonyms :

Calculated chemistry of [ 206347-30-0 ]

Physicochemical Properties

Num. heavy atoms :	10
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.25
Num. rotatable bonds :	0
Num. H-bond acceptors :	1.0
Num. H-bond donors :	0.0
Molar Refractivity :	43.49
TPSA :	9.23 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.65 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.23
Log Po/w (XLOGP3) :	2.62
Log Po/w (WLOGP) :	2.38
Log Po/w (MLOGP) :	2.49
Log Po/w (SILICOS-IT) :	3.21
Consensus Log Po/w :	2.59

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	2.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.17
Solubility :	0.135 mg/ml ; 0.000678 mol/l
Class :	Soluble
Log S (Ali) :	-2.46
Solubility :	0.684 mg/ml ; 0.00344 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.54
Solubility :	0.0567 mg/ml ; 0.000285 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.79

Safety of [ 206347-30-0 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H332-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 206347-30-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 206347-30-0 ]
Downstream synthetic route of [ 206347-30-0 ]

[ 206347-30-0 ] Synthesis Path-Upstream 1~3

1
[ 206347-32-2 ]
[ 206347-30-0 ]

Yield	Reaction Conditions	Operation in experiment
78%	With n-butyllithium In tetrahydrofuran; hexane at -78 - 0℃; for 1 h;	Synthesis of 7-Bromo-2,3-dihydro-benzofuran A solution of 2.5M n-BuLi (13.0 ml, 32.5 mmol) was added to a solution of 1,3-dibromo-2-(2-bromo-ethoxy)-benzene (11.5, 32.0 mmol) in 115 ml of THF and 28 ml of hexane at -78° C. over 30 mins. The reaction was continued at -78° C. for 30 minutes, then warmed to 0° C. The mixture was poured into water (100 ml) and the aqueous phase was extracted with ether. The combined organic layers were dried over Na₂SO₄, filtered, and concentrated to give a pale yellow oil. Silica gel chromatography using a gradient of ethyl acetate in hexanes to give 7-bromo-2,3-dihydro-benzofuran as colorless needles (5.00 g, 78percent). ¹H NMR (500 MHz, DMSO-d₆) δ 7.27(dd, 1 Hz, 8 Hz, 1H), 7.20 (dd, 1 Hz, 7.5 Hz, 1H), 6.75 (t, 7.8 Hz, 1H), 4.59 (t, 9 Hz, 2H), 3.28 (t, 8.8 Hz, 2H).

Reference： [1] Tetrahedron Letters, 1998, vol. 39, # 15, p. 2219 - 2222
[2] Patent: US2006/30583, 2006, A1, . Location in patent: Page/Page column 104
[3] Patent: EP1972628, 2008, A1, . Location in patent: Page/Page column 56-57
[4] Patent: US2010/16297, 2010, A1, . Location in patent: Page/Page column 34

2
[ 206347-32-2 ]
[ 496-16-2 ]
[ 206347-30-0 ]

Reference： [1] Patent: WO2005/58858, 2005, A1, . Location in patent: Page/Page column 168-169

3
[ 608-33-3 ]
[ 206347-30-0 ]

Reference： [1] Tetrahedron Letters, 1998, vol. 39, # 15, p. 2219 - 2222

[ 206347-30-0 ] Synthesis Path-Downstream 1~40

1
[ 206347-32-2 ]
[ 206347-30-0 ]

Yield	Reaction Conditions	Operation in experiment
78%	With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0℃; for 1h;	Synthesis of 7-Bromo-2,3-dihydro-benzofuran A solution of 2.5M n-BuLi (13.0 ml, 32.5 mmol) was added to a solution of 1,3-dibromo-2-(2-bromo-ethoxy)-benzene (11.5, 32.0 mmol) in 115 ml of THF and 28 ml of hexane at -78 C. over 30 mins. The reaction was continued at -78 C. for 30 minutes, then warmed to 0 C. The mixture was poured into water (100 ml) and the aqueous phase was extracted with ether. The combined organic layers were dried over Na2SO4, filtered, and concentrated to give a pale yellow oil. Silica gel chromatography using a gradient of ethyl acetate in hexanes to give 7-bromo-2,3-dihydro-benzofuran as colorless needles (5.00 g, 78%). 1H NMR (500 MHz, DMSO-d6) delta 7.27(dd, 1 Hz, 8 Hz, 1H), 7.20 (dd, 1 Hz, 7.5 Hz, 1H), 6.75 (t, 7.8 Hz, 1H), 4.59 (t, 9 Hz, 2H), 3.28 (t, 8.8 Hz, 2H).
	With n-butyllithium; In tetrahydrofuran; hexane; at -80℃;	1-(2,3-Dihydrobenzofuran-7-yl)piperazine (C7i); In detail, for the synthesis of compound C7i 2,6-dibromophenole (29 mmol) (C8a; R4-R6 = H) is mixed with 1,2-dibromoethane (29 mmol) (r = 1) unter basic aqueous conditions (NaOH) and heated at reflux for 18 hrs. The resulting monoalkylation product can be solved in THF/hexane (4/1), cooled to -80 C and then, a solution of 2,5 M butyllithium (18mmol) in hexane is added dropwise (17.1 mmol). The cyclisation product 7-bromo-2,3-dihydrobenzofurane (4 mmol) (C8b; r = 1) can be suspended together with NaOtBu (20 mmol), Pd2(dba)3 (2 mol%), BINAP (2 mol%) and piperazine (8 mmol) in 5 ml dry toluene and heated at 117C for 6 hrs to get the product.
	With n-butyllithium; In tetrahydrofuran; at -100℃;	2. Synthesis of 2,3-dihydrobenzofuran-7-sulfonyl chloride; n-Butyllithium (23 mmol) was added dropwise to a solution of 1,3-dibromo-2-(2-bromoethoxy)benzene (21.8 mmol) in tetrahydrofuran (100 mL) at -100 C. and the reaction mixture was maintained for 30 min. n-Butyllithium (23 mmol) was added dropwise and the reaction mixture was maintained at -100 C. for an additional 60 min. Sulfur dioxide (43.8 mmol) was added and the reaction mixture was maintained for 2 h between -100 and -85 C. The reaction mixture was diluted with hexane (100 mL) and the precipitated solids were collected by filtration. The solid was suspended in dichloromethane (100 mL) at 0 C. and N-chlorosuccinamide (24.6 mmol) was added in several batches. The reaction mixture was maintained for 60 min at 0 C. and was diluted with dichloromethane (100 mL). The reaction mixture was washed with (2 M) sodium hydrogen sulfate (2×150 mL) and brine (3×100 mL), was dried (sodium sulfate), and was concentrated. The residue was purified by Flash chromatography (1/50 ethyl acetate/petroleum ether) to provide 2,3-dihydrobenzofuran-7-sulfonyl chloride in 51% yield as a light yellow solid. Data: 1H NMR: (CDCl3) delta 3.35 (t, 2H), 4.92 (t, 2H), 6.96 (t, 1H), 7.54 (s, 1H), 7.64 (d, 1H). LC/MS (ES) m/z 283 [C13H18N2O3S+H]+.

Reference： [1]Tetrahedron Letters,1998,vol. 39,p. 2219 - 2222
[2]Patent: US2006/30583,2006,A1 .Location in patent: Page/Page column 104
[3]Patent: EP1972628,2008,A1 .Location in patent: Page/Page column 56-57
[4]Patent: US2010/16297,2010,A1 .Location in patent: Page/Page column 34

2
[ 206347-30-0 ]
[ 57260-71-6 ]
[ 846037-41-0 ]

Yield	Reaction Conditions	Operation in experiment
38%	With sodium t-butanolate;tris-(dibenzylideneacetone)dipalladium(0); tris-(o-tolyl)phosphine; In toluene; for 16h;Heating / reflux;	[1289] A first intermediate compound 4-(2,3-Dihydro-benzofuran-7-yl)-piperazine-1-carboxylic acid tert-butyl ester, was produced as follows: A solution of bis-(dibenzylideneacetone)palladium(0) (4.92 g, 0.16 mol) and toluene (2500 ml) was degassed with nitrogen for 15 minutes. (Note: Degassing was continued during each addition. Time between additions was 15 minutes.) Then added was tri-o-tolylphosphine (4.92 g, 0.16 mol) then sodium t-butoxide (53.8 g, 0.56 mol) then Boc-piperazine (86.8 g, 0.47 mol) then a solution of <strong>[206347-30-0]7-bromo-2,3-dihydro-benzofuran</strong> (79.6 g, 0.40 mol, prepared according to Tetrahedron Lett. 1998, 39, 2219) in toluene (100 ml). The reaction mixture was stirred at reflux for 16 h. By TLC, all starting material had been consumed. The cooled reaction mixture was filtered over a pad of Celite. The filtrate was concentrated under reduced pressure and the residue was triturated with ethyl acetate in heptane (50%). The insoluble material was filtered off and that filtrate was concentrated under reduced pressure. The crude residue was purified by flash column chromatography using ethyl acetate in heptane (50%) to give 46.4 g (38% yield) of the first intermediate compound as a tan solid.

Reference： [1]Patent: US2005/43309,2005,A1 .Location in patent: Page/Page column 104
[2]Tetrahedron Letters,1998,vol. 39,p. 2219 - 2222

3
[ 1692-15-5 ]
[ 206347-30-0 ]
[ 794465-11-5 ]

Reference： [1]Journal of Medicinal Chemistry,2002,vol. 45,p. 165 - 176

4
[ 206347-30-0 ]
2-[4-(2,3-dihydro-benzofuran-7-yl)-3,6-dihydro-2<i>H</i>-pyridin-1-yl]-5-fluoro-indan-1-ol [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2002,vol. 45,p. 165 - 176

5
[ 206347-30-0 ]
(1S,2S)-2-[4-(2,3-Dihydro-benzofuran-7-yl)-piperidin-1-yl]-5-fluoro-indan-1-ol [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2002,vol. 45,p. 165 - 176

6
[ 206347-30-0 ]
4-(2,3-dihydro-benzofuran-7-yl)-1-(5-fluoro-1-oxo-indan-2-yl)-pyridinium; bromide [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2002,vol. 45,p. 165 - 176

7
[ 608-33-3 ]
[ 206347-30-0 ]

Reference： [1]Tetrahedron Letters,1998,vol. 39,p. 2219 - 2222

8
[ 206347-30-0 ]
[ 98205-73-3 ]

Reference： [1]Tetrahedron Letters,1998,vol. 39,p. 2219 - 2222

9
[ 104-15-4 ]
[ 206347-30-0 ]
[ 856679-83-9 ]

Yield	Reaction Conditions	Operation in experiment
	With methanesulfonic acid; phosphorus pentoxide; at 20℃;	INTERMEDIATE 78 7-Bromo-5- [ (4-methylphenyl) sulfonyl]-2, 3-dihydro-l-benzofuran 7-Bromo-1, 2-dihydrobenzofuran (64 mg, 0.3 mmol; Intermediate 77) and para- toluensulfonic acid monohydrate (62 mg, 0.3 mmol) were mixed and then a 1: 10 mixture (by weight) of methanesulfonic and phosphorous pentoxide (1 mL) was added. The resultant mixture was stirred over night at room temperature and was then poured onto ice/water. The obtained crystalline material was filtered and dried to give 120 mg of the title product.'H NMR (400 MHz, CDC13) 8 2.40 (s, 3 H), 3.33 (t, 2 H), 4.73 (t, 2 H), 7.29 (d, 2 H), 7.65 (d, 1 H), 7.79 (d, 2 H), 7.89 (d, 1 H); GC-MS (EI+) for C15Hl3BrSO3 m/z 354 (M+H) +.

Reference： [1]Patent: WO2005/58858,2005,A1 .Location in patent: Page/Page column 169

10
[ 206347-32-2 ]
[ 496-16-2 ]
[ 206347-30-0 ]

Yield	Reaction Conditions	Operation in experiment
	With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0℃;Cooling with ethanol-dry ice;	INTERMEDIATE 77 7-Bromo-2, 3-dihydrobenzofuran* A solution of 2- (2, 6-dibromphenoxy) ethyl bromide (1.08 g, 3 mmol; Intermediate 76) in a mixture of THF (12 mL) and hexane (3 mL) was cooled in a ethanol/dry ice bath for 30 min. n-BuLi in hexane (2 mL of 1.5 M solution) was added dropwise over 15 min. The reaction mixture was stirred at-78 C for another 30 min after which time the bath was allowed to slowly warm to 0 C. The mixture was poured onto water and extracted with diethyl ether (2x100 mL). The combined extract was dried and concentrated to give a pale brown oil (0.5 g) containing the product contaminated with approximately 25 % 2,3- dihydrobenzofuran. This material was used as such for further synthesis but could if necessary be purified by flash chromatography [eluent : hexane- EtOAc/hexane (5: 95) ]. 'H NMR (400 MHz, CDC13) 8 3.30 (t, 2 H), 4.65 (t, 2 H), 6.71 (t, 1 H), 7.11 (dd, 1 H), 7.25 (dd, 1 H). *Previously reported in Tetrahedron Lett. 1998,39, 2219-2222.

Reference： [1]Patent: WO2005/58858,2005,A1 .Location in patent: Page/Page column 168-169

11
[ 608-33-3 ]
[ 206347-30-0 ]
4,5-Bis-(4-chloro-phenyl)-2-(2,3-dihydro-benzofuran-7-yl)-4,5-dihydro-1H-imidazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 21 4,5-Bis-(4-chloro-phenyl)-2-(2,3-dihydro-benzofuran-7-yl)-4,5-dihydro-1H-imidazole was prepared from <strong>[206347-30-0]7-bromo-2,3-dihydro-benzofuran</strong> (prepared from 2,6-dibromo-phenol using the procedure reported by Thomas, G. H. et al. Tetrahedron Lett. 1998, 39, 2219-22) and meso-1,2-bis-(4-chloro-phenyl)-ethane-1,2-diamine in an analogous manner as described in example 20. HR-MS (ES, m/z) calculated for C23H19N2OCl2 [(M+H)+] 409.0869, observed 409.0871.

Reference： [1]Patent: US6617346,2003,B1

12
[ 206347-30-0 ]
[ 111538-45-5 ]
Trans-2-[4-(2,3-dihydrobenzofuran-7-yl)piperid-1-yl]-5-fluoroindan-1-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 31 Trans-2-[4-(2,3-dihydrobenzofuran-7-yl)piperid-1-yl]-5-fluoroindan-1-ol Prepared using, in succession, the methods described in Examples 18, 19 and 23, but using <strong>[206347-30-0]7-bromo-2,3-dihydrobenzofuran</strong> in Step 1 of Example 18, and using 2-bromo-5-fluoro-indan-1-one in Step 2 of Example 18. The melting point (MK) of the title compound is 215-217 C.

Reference： [1]Patent: US5958927,1999,A

13
[ 110-85-0 ]
[ 206347-30-0 ]
[ 98205-73-3 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium t-butanolate;tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 117℃; for 6h;	1-(2,3-Dihydrobenzofuran-7-yl)piperazine (C7i); In detail, for the synthesis of compound C7i 2,6-dibromophenole (29 mmol) (C8a; R4-R6 = H) is mixed with 1,2-dibromoethane (29 mmol) (r = 1) unter basic aqueous conditions (NaOH) and heated at reflux for 18 hrs. The resulting monoalkylation product can be solved in THF/hexane (4/1), cooled to -80 C and then, a solution of 2,5 M butyllithium (18mmol) in hexane is added dropwise (17.1 mmol). The cyclisation product <strong>[206347-30-0]7-bromo-2,3-dihydrobenzofuran</strong>e (4 mmol) (C8b; r = 1) can be suspended together with NaOtBu (20 mmol), Pd2(dba)3 (2 mol%), BINAP (2 mol%) and piperazine (8 mmol) in 5 ml dry toluene and heated at 117C for 6 hrs to get the product.

Reference： [1]Patent: EP1972628,2008,A1 .Location in patent: Page/Page column 56-57

14
[ 206347-30-0 ]
[ 470453-91-9 ]

Reference： [1]Journal of Medicinal Chemistry,2009,vol. 52,p. 4149 - 4160

15
[ 206347-30-0 ]
[ 953408-82-7 ]

Yield	Reaction Conditions	Operation in experiment
		2. Synthesis of 2,3-dihydrobenzofuran-7-sulfonyl chloride; n-Butyllithium (23 mmol) was added dropwise to a solution of 1,3-dibromo-2-(2-bromoethoxy)benzene (21.8 mmol) in tetrahydrofuran (100 mL) at -100 C. and the reaction mixture was maintained for 30 min. n-Butyllithium (23 mmol) was added dropwise and the reaction mixture was maintained at -100 C. for an additional 60 min. Sulfur dioxide (43.8 mmol) was added and the reaction mixture was maintained for 2 h between -100 and -85 C. The reaction mixture was diluted with hexane (100 mL) and the precipitated solids were collected by filtration. The solid was suspended in dichloromethane (100 mL) at 0 C. and N-chlorosuccinamide (24.6 mmol) was added in several batches. The reaction mixture was maintained for 60 min at 0 C. and was diluted with dichloromethane (100 mL). The reaction mixture was washed with (2 M) sodium hydrogen sulfate (2×150 mL) and brine (3×100 mL), was dried (sodium sulfate), and was concentrated. The residue was purified by Flash chromatography (1/50 ethyl acetate/petroleum ether) to provide 2,3-dihydrobenzofuran-7-sulfonyl chloride in 51% yield as a light yellow solid. Data: 1H NMR: (CDCl3) delta 3.35 (t, 2H), 4.92 (t, 2H), 6.96 (t, 1H), 7.54 (s, 1H), 7.64 (d, 1H). LC/MS (ES) m/z 283 [C13H18N2O3S+H]+.

Reference： [1]Patent: US2010/16297,2010,A1 .Location in patent: Page/Page column 34

16
[ 73183-34-3 ]
[ 206347-30-0 ]
7-( 4,4,5,5-tetra methyl-[1,3,2]dioxaborola n-2-yl)-2,3-dihydro-benzofuran [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
56%	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In dimethyl sulfoxide; at 80℃; for 8h;Inert atmosphere;	Compound <strong>[206347-30-0]7-bromobenzodihydrofuran</strong> (0.4 g, 2 mmol), bis(pinacolato)diboron (0.78 g, 3 mmol) and anhydrouspotassium acetate (0.4 g, 4 mmol) were suspended in dimethyl sulfoxide (5 mL) and then [1,1?-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.16 g, 0.2 mmol) was added. The reaction mixture was replacedwith nitrogen threetimes to remove the oxygen inside the system and then heated at 80C for 8 hours. The reaction was cooled to roomtemperature, diluted with ice water (100 mL) and extracted with ethyl acetate (50 mL 3 3). The combined organic phaseswere washed successively with water (50 mL 3 3) and brine (50 mL),dried over anhydrous sodium sulfate, filtered, andthe filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography(petroleum ether: ethyl acetate = 30: 1) to delivercompound 3-c (0.29 g, yield: 56%).1H-NMR (400MHz, CDCl3) delta: 7.53 (d, J=8Hz, 1H), 7.27 (d, J=8Hz, 1H), 6.83 (t, J=8Hz, 1H), 4.63 (t, J=8.8Hz, 1H), 3.16(t, J=8.8Hz, 1H), 1.36 (s, 12H) ppm.
56%	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In dimethyl sulfoxide; at 80℃; for 8h;Inert atmosphere;	The compound <strong>[206347-30-0]7-bromobenzodihydrofuran</strong> (0.4 g, 2 mmol), bis(pinacolato)diboron (0.78 g, 3 mmol) and anhydrous potassium acetate (0.4 g, 4 mmol) were suspended in dimethyl sulfoxide (5 mL), and [1,1'-bis (diphenylphosphino)ferrocene]dichloropalladium (0.16 g, 0.2 mmol) was added. The reaction solution was purged with nitrogen gas for three times to remove the oxygen contained in the system and heated at 80 C. for 8 hours. The reaction was cooled to room temperature, diluted with ice water (100 mL) and extracted with ethyl acetate (50 mL3). The combined organic phase was washed with water (50 mL3) and brine (50 mL) successively, dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether: ethyl acetate=30:1) to give compound 2-b (0.29 g, yield 56%). 1H-NMR (400 MHz, CDCl3) delta: 7.53 (d, J=8 Hz, 1H), 7.27 (d, J=8 Hz, 1H), 6.83 (t, J=8 Hz, 1H), 4.63 (t, J=8.8 Hz, 1H), 3.16 (t, J=8.8 Hz, 1H), 1.36 (s, 12H) ppm

Reference： [1]Patent: EP3287463,2018,A1 .Location in patent: Paragraph 0121; 0122
[2]Patent: US2018/208604,2018,A1 .Location in patent: Paragraph 0148-0150

17
[ 206347-30-0 ]
7-(2,3-dihydro-1-benzofuran-7-yl)-N-[5-methyl-4-(piperidin-4-yl)-2-isopropoxyphenyl]-6-methylthieno[3,2-d]pyrimidin-2-amine [ No CAS ]

Reference： [1]Patent: EP3287463,2018,A1

18
[ 206347-30-0 ]
7-(2,3-dihydro-1-benzofuran-7-yl)-N-(2-methoxy-4-(piperidin-4-yl)phenyl)-6-methylthieno[3,2-d]pyrimidin-2-amine [ No CAS ]

Reference： [1]Patent: EP3287463,2018,A1

19
[ 206347-30-0 ]
C₁₅H₁₁ClN₂OS [ No CAS ]

Reference： [1]Patent: EP3287463,2018,A1
[2]Patent: US2018/208604,2018,A1

20
[ 206347-30-0 ]
C₃₂H₃₆N₄O₄S [ No CAS ]

Reference： [1]Patent: EP3287463,2018,A1

21
[ 206347-30-0 ]
C₃₄H₄₀N₄O₄S [ No CAS ]

Reference： [1]Patent: EP3287463,2018,A1

22
[ 206347-30-0 ]
C₃₅H₄₂N₄O₄S [ No CAS ]

Reference： [1]Patent: EP3287463,2018,A1

23
[ 206347-30-0 ]
7-(2,3-dihydro-1-benzofuran-7-yl)-N-[4-(piperidin-4-yl)-2-isopropoxyphenyl]-6-methylthieno[3,2-d]pyrimidin-2-amine [ No CAS ]

Reference： [1]Patent: EP3287463,2018,A1

24
[ 206347-30-0 ]
N-[7-(2,3-dihydro-1-benzofuran-7-yl)-6-methylthieno[3,2-d]pyrimidinyl-2-yl]-1-(piperidinyl-4-yl)-1H-pyrazol-4-amine [ No CAS ]