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Chemical Structure| 98216-82-1 Chemical Structure| 98216-82-1

Structure of 98216-82-1

Chemical Structure| 98216-82-1

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Product Details of [ 98216-82-1 ]

CAS No. :98216-82-1
Formula : C8H7ClO2
M.W : 170.59
SMILES Code : OC1OCC2=C1C=CC(Cl)=C2

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Application In Synthesis of [ 98216-82-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 98216-82-1 ]

[ 98216-82-1 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 54109-03-4 ]
  • [ 868-18-8 ]
  • [ 98216-82-1 ]
YieldReaction ConditionsOperation in experiment
With diisobutylaluminum hydride; In dichloromethane; toluene; a) 5-Chloro-1,3-dihydro-2-benzofuran-1-ol To a solution of <strong>[54109-03-4]5-chlorophthalide</strong> (3.64 g, 21.6 mmol) in dichloromethane (100 mL) at -78° C. was added di-isobutylaluminium hydride (1M in toluene) (23.8 mL, 23.8 mmol) dropwise. After 1 h the reaction mixture was quenched with a saturated solution of sodium tartrate (250 mL), allowed to warm to room temperature and stirred for 1h. The layers were separated and the aqueous layer extracted with dichloromethane. The combined organic layers were dried (MgSO4), filtered and concentrated in vacuo to yield the title compound as a white solid.
 

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