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Chemical Structure| 99010-10-3 Chemical Structure| 99010-10-3

Structure of 99010-10-3

Chemical Structure| 99010-10-3

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Product Details of [ 99010-10-3 ]

CAS No. :99010-10-3
Formula : C10H11N3
M.W : 173.21
SMILES Code : CNC1=C(N)C=NC2=CC=CC=C12
MDL No. :MFCD12403915

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Application In Synthesis of [ 99010-10-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 99010-10-3 ]

[ 99010-10-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 99010-10-3 ]
  • [ 4857-42-5 ]
  • 4-methylamino-3-[(3-methylisoxazole-5-ylcarbonyl)amino]quinoline [ No CAS ]
YieldReaction ConditionsOperation in experiment
361 mg (67%) With thionyl chloride; In N,N,N,N,N,N-hexamethylphosphoric triamide; ice-water; acetonitrile; Example 102 1-Methyl-2-(3-methylisoxazol-5-yl)-1H-imidazo[4,5-c]quinoline C102 To a solution of 245 mg of <strong>[4857-42-5]3-methylisoxazole-5-carboxylic acid</strong> in 20 ml of hexamethylphosphoramide and 0.4 ml of acetonitrile is added 226 mg of thionyl chloride at -5 - 0°C. After stirring at the same temperature for 30 minutes, 330 mg of 3-amino-4-methylaminoquinoline A15 is added and stirred at 0 - 5°C for 5 hours. The mixture is diluted with 50 ml of ice-water and neutralized with saturated aqueous sodium bicarbonate. The resulting solid is filtered and washed with water to give 361 mg (67percent) of 4-methylamino-3-[(3-methylisoxazole-5-ylcarbonyl)amino]quinoline.
 

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