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Chemical Structure| 99254-90-7 Chemical Structure| 99254-90-7

Structure of 99254-90-7

Chemical Structure| 99254-90-7

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Product Details of [ 99254-90-7 ]

CAS No. :99254-90-7
Formula : C8H4Cl2
M.W : 171.02
SMILES Code : C#CC1=CC(Cl)=CC(Cl)=C1
MDL No. :MFCD11655753
Boiling Point : No data available
InChI Key :QVJKOUQZOSCKNE-UHFFFAOYSA-N
Pubchem ID :13823547

Safety of [ 99254-90-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Application In Synthesis of [ 99254-90-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 99254-90-7 ]

[ 99254-90-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 3032-81-3 ]
  • [ 99254-90-7 ]
YieldReaction ConditionsOperation in experiment
To a solution of zinc, bromide (5.Og, 22.2 mmol) in anhydrous THF (100 mL) at room temperature under a nitrogen atmosphere was added a solution of ethynyl magnesium bromide (0.5 M in THF, 44.4 mL, 44.4 mmol). After 5 minutes 3,5-dichloro-iodobenzene was added (4.03 g, 14.8 mmol) followed by tetrakis-triphenyl phosphine palladium (0) (855 mg, 0.74 mmol). The reaction was stirred at room temperature for 18 hours. The reaction mixture was poured into brine and extracted with ether (4X100 mL). The ether layer was washed with brine, dried over anhydrous MgSO4, filtered and concentrated in vacuo. The residue was purified by flash chromatography with 100percent hexanes to give the title compound as a yellow solid. 1H NMR (CDCl3, 500 MHz): 7.4 (d, 7=1.6 Hz, 2H), 7.3 (d, 7=1.6 Hz, IH), 3.19 (s, IH).
 

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