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Chemical Structure| 99310-43-7 Chemical Structure| 99310-43-7

Structure of 99310-43-7

Chemical Structure| 99310-43-7

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Product Details of [ 99310-43-7 ]

CAS No. :99310-43-7
Formula : C8H16ClNO2
M.W : 193.67
SMILES Code : O=C(O)CCC1NCCCC1.[H]Cl
MDL No. :MFCD09910371

Safety of [ 99310-43-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 99310-43-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 99310-43-7 ]

[ 99310-43-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 15197-75-8 ]
  • [ 7440-44-0 ]
  • [ 10294-56-1 ]
  • [ 116191-61-8 ]
  • [ 99310-43-7 ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; anhydrous phosphorus trichloride; In hydrogenchloride; methanol; water; EXAMPLE 2 1-Hydroxy-3-(piperidin-2-yl)-propane-1,1-diphosphonic acid 1.5 g. 3-(Piperidin-2-yl)-propionic acid hydrochloride (m.p.: 193-195 C., prepared by hydrogenation of 3-(2-pyridyl)-propionic acid in hydrochloric acid medium in the presence of platinum oxide) and 1.3 g. phosphorous acid are melted together at 80 C. After allowing to cool, 1.4 ml. phosphorus trichloride is added dropwise and further heated for 20 hours to 90 C. After cooling, 20 ml. water are carefully added thereto and heated under reflux for 7 hours. The cooled solution is treated with charcoal, filtered and the filtrate evaporated. After drying, the residue is stirred up several times with acetone, then taken up in water, the solution brought with 2N aqueous sodium hydroxide solution to a pH ~5 and mixed with methanol. After stirring for some time with ice cooling, the precipitate is filtered off with suction and dried. There is obtained 1.05 g. (37% of theory) of the monosodium salt x 2 mole water; m.p. 270-274 C.; Mrel: 0.41.
 

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