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Chemical Structure| 99365-40-9 Chemical Structure| 99365-40-9
Chemical Structure| 99365-40-9

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Product Details of 6-Bromooxindole

CAS No. :99365-40-9
Formula : C8H6BrNO
M.W : 212.04
SMILES Code : O=C1NC2=C(C=CC(Br)=C2)C1
MDL No. :MFCD02179605
Boiling Point : No data available
InChI Key :JARRYVQFBQVOBE-UHFFFAOYSA-N
Pubchem ID :2773289

Safety of 6-Bromooxindole

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of 6-Bromooxindole

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 99365-40-9 ]

[ 99365-40-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 34270-90-1 ]
  • [ 99365-40-9 ]
  • [ 1190861-43-8 ]
  • 2
  • [ 5414-19-7 ]
  • [ 99365-40-9 ]
  • [ 1190861-43-8 ]
YieldReaction ConditionsOperation in experiment
31% n-BuLi (2M in hexane, 22.6 mL, 45.27 mmol) was added drop wise at -40C to a solution of 6-bromo-indolin-2-one (3 g, 14.14 mmol) and diisopropylamine (6.3 mL, 45.27 mmol) in THF (60 mL). The mixture was stirred for 45 min at -40C, 1-bromo-2-(2-bromoethoxy)ethane was added drop wise at this temperature and stirring was continued at RT for 16 h. The reaction mixture was quenched with 4N hydrogen chloride solution (40 mL) and the aqueous phase was separated and extracted with EtOAc (3x 60 mL). The combined organic layers were washed with brine (50 mL), dried over Na2S04 and concentrated. The raw product was triturated with hexane (20 mL) and filtered. The filter was washed with hexane/EtOAc = 4:1 (100 mL) affording the target compound as light brown solid. Yield: 1.2 g (31 %). HPLC (method 1 ): Rt = 2.94 min, m/z [M+H]+ = 282.1 (MW calc. 282.13).
 

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