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Chemical Structure| 35899-43-5 Chemical Structure| 35899-43-5
Chemical Structure| 35899-43-5

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Boc-His(Tos)-OH is an amino acid derivative, widely used in life science-related research.

4.5 *For Research Use Only !

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Product Details of Boc-His(Tos)-OH

CAS No. :35899-43-5
Formula : C18H23N3O6S
M.W : 409.46
SMILES Code : O=C(O)[C@H](CC1=CN(S(=O)(C2=CC=C(C)C=C2)=O)C=N1)NC(OC(C)(C)C)=O
MDL No. :MFCD00065967
InChI Key :DCLJSEPKYJSEHW-HNNXBMFYSA-N
Pubchem ID :6455010

Safety of Boc-His(Tos)-OH

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Boc-His(Tos)-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 35899-43-5 ]

[ 35899-43-5 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 29390-67-8 ]
  • [ 35899-43-5 ]
  • C60H92N4O39S [ No CAS ]
  • 2
  • [ 2886-33-1 ]
  • [ 35899-43-5 ]
  • N-Boc-Nim-tosylhistidylaspartic acid dibenzyl ester [ No CAS ]
  • 3
  • [ 13734-34-4 ]
  • [ 13836-37-8 ]
  • [ 47355-10-2 ]
  • [ 35899-43-5 ]
  • N-acetylimidazole [ No CAS ]
  • [ 110392-38-6 ]
  • 4
  • [ 4530-20-5 ]
  • [ 15761-39-4 ]
  • [ 13139-15-6 ]
  • C14H14NPol [ No CAS ]
  • [ 13836-37-8 ]
  • [ 23680-31-1 ]
  • [ 47689-67-8 ]
  • [ 47355-10-2 ]
  • [ 53100-44-0 ]
  • [ 35899-43-5 ]
  • [ 33515-09-2 ]
YieldReaction ConditionsOperation in experiment
General procedure: The peptides were synthesized manually accordingly to the standard Boc protocol [1] and [3]. In the Boc chemistry, after coupling the C-terminal amino acid to the resin, the successive alpha-amino group deprotection and neutralization steps were performed in 30% TFA/DCM (30 min) and 10% TEA/DCM (10 min). The amino acids were coupled with 3-fold excess, using DIC/HOBt in DMF and, if necessary, Boc-amino acid/(N-[(1H-benzotriazol-1-yl)-(dimethylaminomethylene)]-N-methylmethanaminium hexafluorophosphate N-oxide (HBTU)/HOBt (1:1:1), in the presence of excess of diisopropylethylamine (DIEA, 5 equiv.) using 20% DMSO/NMP as the solvent system. After a 3-h coupling period, the qualitative ninhydrin test was performed to estimate the completeness of the reaction. To check the purity of the synthesized peptide sequence attached to the resin, cleavage reactions with small aliquots of resin were carried out in anhydrous HF, at 0 C for 2 h.
  • 5
  • [ 13734-41-3 ]
  • [ 13139-16-7 ]
  • [ 15761-38-3 ]
  • [ 27144-18-9 ]
  • [ 13734-34-4 ]
  • [ 15260-10-3 ]
  • [ 13574-13-5 ]
  • [ 13836-37-8 ]
  • [ 65420-40-8 ]
  • [ 55260-24-7 ]
  • [ 35899-43-5 ]
  • H-LQIFVKTLTGKTITLEVEPSDTIENVK-SCH2CH2CONH2 [ No CAS ]
 

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