Home Cart Sign in  
Chemical Structure| 881639-98-1 Chemical Structure| 881639-98-1

Structure of G-1
CAS No.: 881639-98-1

Chemical Structure| 881639-98-1

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

G-1 is a nonsteroidal, high-affinity, selective agonist of GPR30 that binds with a Ki value of 11 nM.

Synonyms: LNS 8801

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Product Citations

Oladimeji Aladelokun ; Lingeng Lu ; Jie Zheng ; Hong Yan ; Abhishek Jain ; Joanna Gibson , et al.

Abstract: Background Sex-related diferences in colorectal (CRC) incidence and mortality are well-documented. However, the impact of sex on metabolic pathways that drive cancer growth is not well understood. High expression of asparagine synthetase (ASNS) is associated with inferior survival for female CRC patients only. Here, we used a CRISPR/Cas9 technology to generate HCT116 ASNS−/− and HCT 116 ASNS+/+ cancer cell lines. We examine the efects of ASNS deletion on tumor growth and the subsequent rewiring of metabolic pathways in male and female Rag2/IL2RG mice. Results ASNS loss reduces cancer burden in male and female tumor-bearing mice (40% reduction, q < 0.05), triggers metabolic reprogramming including gluconeogenesis, but confers a survival improvement (30 days median survival, q < 0.05) in female tumor-bearing mice alone. Transcriptomic analyses revealed upregulation of G-protein coupled estrogen receptor (GPER1) in tumors from male and female mice with HCT116 ASNS−/− xenograft. Estradiol activates GPER1 in vitro in the presence of ASNS and suppresses tumor growth. Conclusions Our study indicates that inferior survival for female CRC patients with high ASNS may be due to metabolic reprogramming that sustains tumor growth. These fndings have translational relevance as ASNS/GPER1 signaling could be a future therapeutic target to improve the survival of female CRC patients. Keywords Metabolism, Colorectal cancer, ASNS, GPER1, Sex diferences

Keywords: Metabolism ; Colorectal cancer ; ASNS ; GPER1 ; Sex diferences

Purchased from AmBeed:

Alternative Products

Product Details of G-1

CAS No. :881639-98-1
Formula : C21H18BrNO3
M.W : 412.28
SMILES Code : CC(C1=CC2=C(N[C@H](C3=C(Br)C=C(OCO4)C4=C3)[C@@]5([H])[C@]2([H])C=CC5)C=C1)=O
Synonyms :
LNS 8801
MDL No. :MFCD16618392

Safety of G-1

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H319-H332-H372-H400
Precautionary Statements:P260-P264-P270-P273-P280-P301+P312+P330-P304+P312-P305+P351+P338-P314-P337+P313-P391-P501
Class:9
UN#:3077
Packing Group:

Related Pathways of G-1

GPCR

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.43mL

0.49mL

0.24mL

12.13mL

2.43mL

1.21mL

24.26mL

4.85mL

2.43mL

References

 

Historical Records

Categories