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Chemical Structure| 71026-66-9 Chemical Structure| 71026-66-9
Chemical Structure| 71026-66-9

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Product Details of N-Boc-p-phenylenediamine

CAS No. :71026-66-9
Formula : C11H16N2O2
M.W : 208.26
SMILES Code : O=C(OC(C)(C)C)NC1=CC=C(N)C=C1
MDL No. :MFCD00043022
InChI Key :WIVYTYZCVWHWSH-UHFFFAOYSA-N
Pubchem ID :688611

Safety of N-Boc-p-phenylenediamine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H317
Precautionary Statements:P280

Application In Synthesis of N-Boc-p-phenylenediamine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 71026-66-9 ]

[ 71026-66-9 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 71026-66-9 ]
  • [ 483324-01-2 ]
  • C20H21N5O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; XPhos; In tert-butyl alcohol; at 90℃; for 6h; Buchwald coupling [00336] To a solution of 4-substituted-2-chloropyrimide in i-butanol was added t- butyl-4-aminophenylcarbamate or i-butyl-3-aminophenylcarbamate (1.0 equiv.), K2C03 (1.0 equiv.), X-Phos (0.1 equiv.) and Pd2(dba)3. After heating at 90 C for 6 h, the reaction mixture was diluted with a mixture of chloroform and 2-propanol (4: 1). The organic layer was washed with water (3x), dried over MgS04, filtered and concentrated under reduced pressure. The resulting crude product was used for the next step without further purification.
  • 2
  • [ 3973-08-8 ]
  • [ 71026-66-9 ]
  • {4-[(thiazole-4-carbonyl)-amino]-phenyl}-carbamic acid <i>tert</i>-butyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20℃; for 1h;Inert atmosphere; A solution of DIPEA (13 mL, 72 mmol), A1a (4.8 g, 37 mmol) and B1 a (6.0 g, 29 mmol, Senn Chemicals AG) in DMF (60 mL) is treated with HATU (15 g, 40 mmol) at RT. The reaction is stirred for 1 h and then is diluted with water and EtOAc. The organic layer is separated, washed with water (2x), dried over MgS04 and evaporated to dryness. The product is purified by Combiflash to give B1 b.
  • 3
  • [ 74440-82-7 ]
  • [ 71026-66-9 ]
  • tert-butyl N-{4-[(3-iodo-5-methoxybenzene)amido]phenyl}carbamate [ No CAS ]
 

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