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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 2632-13-5 Chemical Structure| 2632-13-5

Structure of PTP inhibitor 1
CAS No.: 2632-13-5

Chemical Structure| 2632-13-5

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PTP Inhibitor II is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor, it covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with Ki value of 128 μM.

Synonyms: α-Bromo-4’-methoxyacetophenone; NSC 129010; Protein Tyrosine Phosphatase Inhibitor II

4.5 *For Research Use Only !

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Product Citations

Product Citations

Fabian Fischer ; Julian Schliehe-Diecks ; Jia-Wey Tu ; Tanja Gangnus ; Yu Lin Ho ; Mara Hebeis , et al.

Abstract: Histone deacetylase inhibitors (HDACi) are established anticancer drugs, especially in hematological cancers. This study aimed to design, synthesize, and evaluate a set of HDACi featuring a pentyloxyamide connecting unit linker region and substituted phenylthiazole cap groups. A structural optimization program yielded HDACi with nanomolar inhibitory activity against histone deacetylase class I/IIb enzymes. The novel inhibitors (4d and 4m) showed superior antileukemic activity compared to several approved HDACi. Furthermore, 4d and 4m displayed synergistic activity when combined with chemotherapeutics, decitabine, and clofarabine. In vitro pharmacokinetic studies showed the most promising profile for 4d with intermediate microsomal stability, excellent plasma stability, and concentration-independent plasma protein binding. Additionally, 4d demonstrated comparable in vivo pharmacokinetics to vorinostat. When administered in vivo, 4d effectively inhibited the proliferation of leukemia cells without causing toxicity. Furthermore, the binding modes of 4d and 4m to the catalytic domain 2 of HDAC6 from Danio rerio were determined by X-ray crystallography.

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Product Details of PTP inhibitor 1

CAS No. :2632-13-5
Formula : C9H9BrO2
M.W : 229.07
SMILES Code : COC1=CC=C(C(CBr)=O)C=C1
Synonyms :
α-Bromo-4’-methoxyacetophenone; NSC 129010; Protein Tyrosine Phosphatase Inhibitor II
MDL No. :MFCD00000201
InChI Key :XQJAHBHCLXUGEP-UHFFFAOYSA-N
Pubchem ID :4965

Safety of PTP inhibitor 1

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302+H312+H332-H314-H290
Precautionary Statements:P260-P280-P303+P361+P353-P301+P330+P331-P304+P340+P310-P305+P351+P338+P310
Class:8
UN#:3261
Packing Group:

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.37mL

0.87mL

0.44mL

21.83mL

4.37mL

2.18mL

43.65mL

8.73mL

4.37mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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