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Chemical Structure| 1200443-21-5 Chemical Structure| 1200443-21-5

Structure of Targocil
CAS No.: 1200443-21-5

Chemical Structure| 1200443-21-5

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Targocil is a novel antibiotics against Methicillin-resistant Staphylococcus aureus (MRSA).

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Product Citations

Product Citations

Vasiliki T. Chioti ; Kirklin L. McWhorter ; Tamra C. Blue ; Yuchen Li ; Fei Xu ; Philip D. Jeffrey , et al.

Abstract: Keratinicyclins and keratinimicins are recently discovered glycopeptide antibiotics. Keratinimicins show broad-spectrum activity against Gram-positive bacteria, while keratinicyclins form a new chemotype by virtue of an unusual moiety and exhibit specifc antibiosis against Clostridioides difcile. Here we report the mechanism of action of keratinicyclin B (KCB). We fnd that steric constraints preclude KCB from binding peptidoglycan termini. Instead, KCB inhibits C. difcile growth by binding wall teichoic acids (WTAs) and interfering with cell wall remodeling. A computational model, guided by biochemical studies, provides an image of the interaction of KCB with C. difcile WTAs and shows that the same H-bonding framework used by glycopeptide antibiotics to bind peptidoglycan termini is used by KCB for interacting with WTAs. Analysis of KCB in combination with (VAN) shows highly synergistic and specifc antimicrobial activity, and that nanomolar combinations of the two drugs are sufcient for complete growth inhibition of C. difcile, while leaving common commensal strains unafected.

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Product Details of Targocil

CAS No. :1200443-21-5
Formula : C21H22ClN5O4S
M.W : 475.95
SMILES Code : COC1=CC2=C(C=C1OC)C(N(CC)CC)=NC3=C(S(=O)(C4=CC=C(Cl)C=C4)=O)N=NN32
MDL No. :MFCD19441262
InChI Key :TYNZGYMGTTUYKZ-UHFFFAOYSA-N
Pubchem ID :44547009

Safety of Targocil

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.10mL

0.42mL

0.21mL

10.51mL

2.10mL

1.05mL

21.01mL

4.20mL

2.10mL

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