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Chemical Structure| 1192500-31-4 Chemical Structure| 1192500-31-4

Structure of Avibactam free acid
CAS No.: 1192500-31-4

Chemical Structure| 1192500-31-4

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Avibactam free acid is a covalent, reversible β-lactamase inhibitor, and inhibits β-lactamase TEM-1 and CTX-M-15 with IC50 of 8 nM and 5 nM, respectively.

Synonyms: NXL-104 free acid; Avibactam(free acid)

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Product Citations

Product Citations

Brzeski, Jakub ; Nowicka, Paulina ; Samsonov, Sergey A. ;

Abstract: There is a constant necessity of finding new, reliable antimicrobials, due to the rapid emergence of antibiotic resistant bacteria. This paper tries to address this issue, as the possibility of formation of Pd(II) and Pt(II) coordination compounds of avibactam and their properties were investigated. Moreover, the effect of complexation on interactions with OXA-48 β-lactamase was thoroughly examined with computational approaches. It was found that the formation of Pd(II) and Pt(II) complexes of avibactam is thermodynamically favorable. Furthermore, it was observed that the binding energies of Pd(Avi)2 to OXA-48 approach that of Avibactam, whereas that of Pt(Avi)2 are somewhat less favorable. As such, they may be considered as new potential non-β-lactam β-lactamase inhibitors.

Keywords: Avibactam ; Palladium complex ; Platinum complex ; Molecular dynamics

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Product Details of Avibactam free acid

CAS No. :1192500-31-4
Formula : C7H11N3O6S
M.W : 265.24
SMILES Code : O=S(ON1[C@]2([H])CC[C@@H](C(N)=O)[N@@](C2)C1=O)(O)=O
Synonyms :
NXL-104 free acid; Avibactam(free acid)
MDL No. :MFCD30478396

Safety of Avibactam free acid

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H315-H318-H335
Precautionary Statements:P280-P302+P352-P305+P351+P338+P310
Class:9
UN#:3077
Packing Group:

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Enterobacterales 8/4 µg/mL (protocol 1) or 12/4 µg/mL (protocol 2) 4.5 hours To detect AZA susceptibility/resistance in Enterobacterales, the test sensitivity and specificity were 100% and 97.7% (protocol 1) and 100% and 100% (protocol 2). PMC10595063
Burkholderia multivorans ATCC 17616 32 µg/ml 1 hour To evaluate the induction of PenA expression by piperacillin in clinical isolates of Burkholderia multivorans. PMC6663914
Escherichia coli ATCC 25922 0.016/4 to 0.12/4 mg/mL Establish MIC quality control ranges for Ceftibuten-avibactam PMC10358160
Escherichia coli NCTC 13353 0.03/4 to 0.12/4 mg/mL Establish MIC quality control ranges for Ceftibuten-avibactam PMC10358160
Klebsiella pneumoniae ATCC 700603 0.06/4 to 0.25/4 mg/mL Establish MIC quality control ranges for Ceftibuten-avibactam PMC10358160
Klebsiella pneumoniae ATCC BAA-1705 0.03/4 to 0.25/4 mg/mL Establish MIC quality control ranges for Ceftibuten-avibactam PMC10358160
Klebsiella pneumoniae ATCC BAA-2814 0.12/4 to 0.5/4 mg/mL Establish MIC quality control ranges for Ceftibuten-avibactam PMC10358160

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.77mL

0.75mL

0.38mL

18.85mL

3.77mL

1.89mL

37.70mL

7.54mL

3.77mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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