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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
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Chemical Structure| 66095-18-9 Chemical Structure| 66095-18-9
Chemical Structure| 66095-18-9

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Benzyl (6-aminohexyl)carbamate is a carbamate derivative with a benzyl group and an amino hexyl chain. It is used in peptide and drug synthesis.

4.5 *For Research Use Only !

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Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

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Product Details of Benzyl (6-aminohexyl)carbamate

CAS No. :66095-18-9
Formula : C14H22N2O2
M.W : 250.34
SMILES Code : O=C(OCC1=CC=CC=C1)NCCCCCCN
MDL No. :MFCD01312219

Safety of Benzyl (6-aminohexyl)carbamate

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P403+P233-P501
Class:8
UN#:2735
Packing Group:

Application In Synthesis of Benzyl (6-aminohexyl)carbamate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 66095-18-9 ]

[ 66095-18-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 124-09-4 ]
  • [ 28170-07-2 ]
  • [ 66095-18-9 ]
YieldReaction ConditionsOperation in experiment
31% In ethanol; at 20℃; for 2h;Reflux; A mixture of 1,6-diaminohexane 39 (39.15 g, 0.338 mol) and <strong>[28170-07-2]benzyl phenyl carbonate</strong> (35.7 g, 0.156 mol) inethanol (125 ml) was stirred for 2 hours at room temperature and subsequently heated for an additional hour atreflux to achieve full conversion. The reaction mixture was allowed to cool to room temperature, affording awhite precipitate. After removing the precipitate by filtration, the supernatant was evaporated to dryness anddissolved in 330 ml 2 M aqueous HCl. The resulting solution was extracted with dichloromethane (DCM)(2x150 ml). The aqueous phase was subsequently adjusted to pH = 10 with 6 M aqueous NaOH and extractedwith DCM (3x150 ml). All organic phases were combined, dried over Na2SO4, evaporated to dryness, anddissolved in 200 ml diethyl ether. The resulting solution was extracted with 1M aqueous NaOH (3x50 ml), driedover Na2SO4, and evaporated to dryness to afford crude 40. The product was recrystallized from diethyl ether at-18C to afford white crystals (12.0 g, 31 %). 1H NMR (400 MHz, CDCl3): delta 1.03 (br.s, 2H), 1.58-1.14 (m, 8H),2.66 (t, J = 6.9 Hz, 2H), 3.18 (q, J = 6.7 Hz, 2H), 4.83 (br.s, 1H), 5.08 (s, 2H), 7.45 - 7.19 (m, 5H) ppm. 13CNMR (400 MHz, CDCl3): delta 26.63, 26.68, 30.07, 33.83, 41.12, 42.25, 66.67, 128.17, 128.21, 128.61, 136.78,156.51 ppm. RP-LCMS: calc. Mw= 250.2 g/mol, found m/z: 251.3 [M+H]+.Synthesis of
 

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