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Chemical Structure| 153086-78-3 Chemical Structure| 153086-78-3
Chemical Structure| 153086-78-3

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Boc-NH-PEG2-C2-NH2 is a PEG-based compound with a Boc-protected amine group. The PEG linker offers high solubility and biocompatibility, while the C2 spacer and the amine group provide flexibility for conjugation with other molecules or targeting ligands. This compound is useful for synthesizing PROTAC molecules and other bioconjugates.

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Product Details of Boc-NH-PEG2-C2-NH2

CAS No. :153086-78-3
Formula : C11H24N2O4
M.W : 248.32
SMILES Code : O=C(OC(C)(C)C)NCCOCCOCCN
MDL No. :MFCD03788155
InChI Key :OCUICOFGFQENAS-UHFFFAOYSA-N
Pubchem ID :9881394

Safety of Boc-NH-PEG2-C2-NH2

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Boc-NH-PEG2-C2-NH2

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 153086-78-3 ]

[ 153086-78-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 64987-85-5 ]
  • [ 153086-78-3 ]
  • C23H37N3O7 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20℃; for 0.333333h; SMCC (0.334 g), monoprotected diamine reagent (0.248 g) and DIEA (0.17 mL) were dissolved in dichloromethane (20 mL), stirred at ambient temperature for 20 min. The product was purified by flash chromatography, and further reacted with TFA (2 mL) and anisole (0.5 mL) for 2 hours, and the final product was isolated after removal of TFA and anisole. The corresponding hydrochloride salt was prepared by dissolving in HCl and evaporating off HCl. Mass spectrum: M+H m/e 368. The process schematically shown in Scheme-6.
  • 2
  • [ 5672-83-3 ]
  • [ 153086-78-3 ]
  • C25H39N3O9 [ No CAS ]
YieldReaction ConditionsOperation in experiment
100% With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20℃; for 2h;Inert atmosphere; To a solution of compound IntCl-L-la (6 g, 24.16 mmol) and z-L-Glu-OMe (5.94 g,20.13 mmol) in DIVIF (30 mL) was added PyBOP (15.72 g, 30.20 mmol) and DIPEA (10.52 mL,60.39 mmol) at 0°C under N2 atmosphere. The mixture was stirred at room temperature for 2hours. EA (20 mL X 6), H20 (20 mL), and brine (200 mL) were added to the mixture. Theorganic layer was dried over anhydrous Na2SO4, filtered and concentrated under reducedpressure. The residue was purified by column chromatography to obtain compound IntCl-L- lb (10.6 g, quant.).?H NIVIR (400 MHz, CDC13) (57.40-7.28 (m, 5H), 6.32 (s, 1H), 5.80 (s, 1H), 5.11 (s,2H), 5.02 (s, 1H), 4.36 (s, 1H), 3.74 (s, 3H), 3.60 (s, 4H), 3.54 (s, 4H), 3.44-3.43 (m, 2H), 3.38-3.21 (m, 2H), 2.30-2.20 (m, 3H), 2.04-2.00 (m, 1H), 1.76 (s, 1H), 1.44 (s, 9H). El-MS m/z: 526 (M).
 

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