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Structure of Candesartan
CAS No.: 139481-59-7
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Candesartan is a benzimidazole-derived and competitive AT1 inhibitor with IC50 value of 0.26 nM.
Synonyms: CV 11974; Candesartan M1
4.5
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CAS No. : | 139481-59-7 |
Formula : | C24H20N6O3 |
M.W : | 440.45 |
SMILES Code : | C1=CC=C(C2=C1N=C([N]2CC3=CC=C(C=C3)C4=CC=CC=C4C5=N[NH]N=N5)OCC)C(O)=O |
Synonyms : |
CV 11974; Candesartan M1
|
MDL No. : | MFCD00864463 |
InChI Key : | HTQMVQVXFRQIKW-UHFFFAOYSA-N |
Pubchem ID : | 2541 |
GHS Pictogram: |
![]() ![]() |
Signal Word: | Danger |
Hazard Statements: | H315-H319-H228 |
Precautionary Statements: | P240-P210-P241-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
Class: | 4.1 |
UN#: | 1325 |
Packing Group: | Ⅱ |
Target |
|
In Vitro:
Concentration | Treated Time | Description | References |
J774A.1 macrophages | 7.5, 15, 30 µM | 0.5 hours | Candesartan dose-dependently inhibited IL-1β secretion and reduced IL-18 secretion and active caspase-1 expression. | PMC9163344 |
Human retinal endothelial cells | 1μg/ml | 24 hours | To examine the proangiogenic effects of candesartan in human endothelial cells under normoxia and hypoxia, results showed that candesartan enhanced VEGFR2 activation and tube formation under hypoxia, and this effect was dependent on HO-1 expression. | PMC4366359 |
Bovine Retinal Endothelial Cells (BREC) | 1 μM | 24 hours | Candesartan restored GLO-I activity and mRNA levels in BREC and reduced NO● production. | PMC2992784 |
Bovine Retinal Pericytes (BRP) | 1 μM | 24 hours | Candesartan restored GLO-I activity and mRNA levels in BRP and reduced NO● production. | PMC2992784 |
Monocytes | 0.1 µM, 1 µM, 5 µM | 24 hours | Pretreatment with candesartan significantly reduced Pam3CSK4 or LPS-induced TLR2 and TLR4 expression at both mRNA and protein levels, along with decreased activity of NF-κB and expression of IL-1β, IL-6, TNF-α, and MCP-1 | PMC2676176 |
THP-1 cells | 1 µM | 24 hours | Pretreatment with candesartan significantly reduced Pam3CSK4 or LPS-induced TLR2 and TLR4 expression | PMC2676176 |
BeWo cells | 1 µM | 48 hours | To investigate the effect of candesartan on PPARγ and its target genes in BeWo cells. Results showed that candesartan had no significant effect on PPARγ target genes in BeWo cells. | PMC9603971 |
SGHPL-4 cells | 1 µM | 48 hours | To investigate the effect of candesartan on PPARγ and its target genes in SGHPL-4 cells. Results showed that candesartan had no significant effect on PPARγ target genes in SGHPL-4 cells. | PMC9603971 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
C57BL/6 mice | Traumatic brain injury (TBI) model | Subcutaneous injection | 1 mg/kg/day | Continuous administration until killing (3 or 28 days) | Candesartan treatment reduced the lesion volume after CCI injury by approximately 50%, decreased the number of dying neurons, lessened the number of activated microglial cells, protected cerebral blood flow (CBF), and reduced the expression of the cytokine TGF b1 while increasing expression of TGF b3. Candesartan-treated mice also showed better motor skills on the rotarod 3 days after injury, and improved performance in the Morris water maze 4 weeks after injury. | PMC3499714 |
C57Bl/6J mice | Ischemic retinopathy model | Intraperitoneal injection | 1mg/kg and 10mg/kg | Once daily for 5 days | To examine the vascular protective effects of candesartan in an ischemic retinopathy model, results showed that candesartan significantly reduced pathological neovascularization and promoted physiological revascularization of the central retina by suppressing iNOS expression and restoring HO-1 expression. | PMC4366359 |
Transgenic Ren-2 rats | Diabetic model | Gavage | 5 mg/kg/day | Once daily for 20 weeks | Candesartan reduced retinal acellular capillaries, inflammation, and iNOS in diabetic Ren-2 rats and restored GLO-I activity. | PMC2992784 |
Rats | Diabetes and atherosclerosis-induced ischemic stroke model | Nasal administration | 1 mg/kg | Once daily for 10 days | To evaluate the therapeutic effects of the CLEP formulation on diabetes-associated stroke. The results showed that the CLEP formulation significantly reduced infarction after stroke, decreased flexion, spontaneous motor activity, and time spent in the target quadrant, and enhanced grip strength. | PMC10801309 |
C57BL/6JNal mice | MSU-induced peritonitis model | Oral | 30 mg/kg/day | Once daily for 3 days | Oral administration of candesartan significantly reduced NLRP3 inflammasome activity in the MSU-induced peritonitis mouse model, decreasing the levels of IL-1β and active caspase-1 in the peritoneal fluids. | PMC9163344 |
C57BLJ/6 mice | Normal mice | Intraperitoneal injection | 2 mg/kg body weight | Once daily for 10 days | Candesartan treatment significantly reduced Pam3CSK4-induced TLR2 expression and LPS-induced TLR4 expression | PMC2676176 |
Chicken embryos | Chorioallantoic membrane (CAM) model | Chorioallantoic membrane | 0.1 µM | Single dose, 24 hours | To investigate the effect of candesartan on angiogenesis in the chorioallantoic membrane of chicken embryos. Results showed that angiotensin II (AngII) treatment significantly increased angiogenesis. | PMC9603971 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT00863980 | Acute Myocardial Infarction ... More >> Angina Pectoris Myocardial Ischemia Acute Coronary Syndrome Hypertension Less << | Not Applicable | Terminated(Principle investiga... More >>tor resigned in 2013) Less << | - | Japan ... More >> Shakaihoken Kobe Central Hospital Kobe, Japan, 651-1145 Akashi Municipal Hospital Kobe, Japan, 673-8501 Kouseikai Takeda Hospital Kyoto, Japan, 600-8558 Aijyukai Dohjin Hospital Kyoto, Japan, 602-0917 Kyoto Second Red Cross Hospital Kyoto, Japan, 602-8026 Kyoto Prefectural University of Medicine Kyoto, Japan, 602-8566 Social Insurance Kyoto Hospital Kyoto, Japan, 603-8151 Kyoto Kojyo Hokenkai Kyoto, Japan, 604-8472 Kyoto City Hospital Kyoto, Japan, 604-8845 Kyoto First Red Cross Hospital Kyoto, Japan, 605-0981 Aiseikai Yamashina Hospital Kyoto, Japan, 607-8086 Tanabe Central Hospital Kyoto, Japan, 610-0334 Rakusai Simizu Hospital Kyoto, Japan, 610-1106 Uji Hospital Kyoto, Japan, 611-0011 Kyoto Yawata Hospital Kyoto, Japan, 614-8114 Seizinkai Simizu Hospital Kyoto, Japan, 615-8237 Saiseikai Kyoto Hospital Kyoto, Japan, 617-0814 Public Yamasiro Hospital Kyoto, Japan, 619-0214 Gakkentoshi Hospital Kyoto, Japan, 619-0238 Fukuchiyama City Hospital Kyoto, Japan, 620-8505 Ayabe City Hospital Kyoto, Japan, 623-0011 Maizuru Red Cross Hospital Kyoto, Japan, 624-0906 National Hospital Organization Maizuru Medical Center Kyoto, Japan, 625-8502 Maizuru Kyosai Hospital Kyoto, Japan, 625-8585 Public Nantan Hospital Kyoto, Japan, 629-0197 Kyoto Prefectural Yosanoumi Hospital Kyoto, Japan, 629-2261 Kumihama Hospital Kyoto, Japan, 629-3403 Sakurakai Takahashi Hospital Kyoto, Japan, 654-0026 Yuuseikai Midorigaoka Hospital Osaka, Japan, 569-1121 Matsushita Memorial Hospital Osaka, Japan, 570-8540 Saiseikai Shiga Hospital Shiga, Japan, 520-3046 Omihachiman Community Medical Center Shiga, Japan, 523-0892 Less << |
NCT00130975 | Atrial Fibrillation | PHASE3 | COMPLETED | 2025-09-05 | Ulleval University Hospital, O... More >>slo, 0407, Norway|Asker & Baerum Hospital, Rud, 1309, Norway Less << |
NCT00150631 | Hypertension | PHASE3 | UNKNOWN | 2025-12-14 | Karin Skov, Aarhus, 8000, Denm... More >>ark Less << |
NCT00430833 | Hypertrophic Cardiomyopathy | Phase 2 | Unknown | - | Czech Republic ... More >> Cardiocenter, Third Faculty of Medicine, Charles University Prague, Czech Republic, 10034 Less << |
NCT00538486 | Hypertension ... More >>Obesity Less << | Phase 4 | Completed | - | China ... More >> The third hospital affiliated to the Third Military Medical University Chongqing, China, 400042 Less << |
NCT00184587 | Cluster Headache | Phase 2 | Completed | - | Norway ... More >> Norwegian National Headache Centre St.Olavs Hospital Trondheim, Norway, 7006 Less << |
NCT00679484 | Chronic Heart Failure ... More >> High Blood B-type (or Brain) Natriuretic Peptide (BNP) Level Less << | Phase 3 | Terminated(Lack of subject rec... More >>ruitment) Less << | - | France ... More >> Bron, France Cedex, France Cholet, France Langres, France Mannheim, France Pontoise, France Roubaix, France Germany Bad Nauheim, Germany Berlin, Germany Lambrecht, Germany Netherlands Ad Delft, Netherlands Less << |
NCT01062451 | Methamphetamine Dependence ... More >> Methamphetamine Abuse Substance Abuse Less << | Phase 1 | Active, not recruiting | December 2018 | United States, Texas ... More >> Michael E. DeBakey VA Medical Center Houston, Texas, United States, 77030 Less << |
NCT00154037 | Healthy Subjects | Not Applicable | Completed | - | Germany ... More >> Institute of Clinical Pharmacology, Medical Faculty, University of Technology Dresden, Germany, 01307 Less << |
NCT02609711 | Healthy Male Subjects | Phase 1 | Unknown | - | Korea, Republic of ... More >> Inha Univ. Hospital Incheon, Korea, Republic of Less << |
NCT00288717 | Hypertension | Not Applicable | Unknown | - | Japan ... More >> Saitama Medical School Department of Renal Medicine Recruiting Saitama City, Saitama, Japan, 350-0495 Contact: Hidetomo Nakamoto, MD +81-492-76-1258 nakamo_h@saitama-med.ac.jp Principal Investigator: Hidetomo Nakamoto, MD Less << |
NCT00644475 | Essential Hypertension | Phase 3 | Unknown | March 2009 | Italy ... More >> University of Pavia Recruiting Pavia, Italy, 27100 Contact: Giuseppe Derosa, MD +39 0382 502614 giuseppe.derosa@unipv.it Contact: Roberto Fogari, MD +39 0382 526217 r.fogari@unipv.it Principal Investigator: Giuseppe Derosa, MD Less << |
NCT00564057 | HIV Infections ... More >> Hypertension Less << | Phase 4 | Unknown | September 2009 | Italy ... More >> University of Insubria, Department of Clinical Medicine Recruiting Varese, Italy, 21100 Less << |
NCT00232882 | Hypertension | Phase 4 | Completed | - | Canada, Quebec ... More >> Institut de Recherches Cliniques de Montréal Montréal, Quebec, Canada, H2W 1R7 Less << |
NCT00319202 | Glucose Intolerance ... More >> Obesity Less << | Phase 4 | Terminated(Difficulties in com... More >>pleting the required sample size) Less << | - | Colombia ... More >> Fundación Cardiovascular de Colombia Floridablanca, Santander, Colombia, 10000 Less << |
NCT01303783 | Hypertension, Essential | Phase 2 | Completed | - | - |
NCT00573742 | - | Completed | - | Romania ... More >> Research Site Bacau, Romania Research Site Braila, Romania Research Site Brasov, Romania Research Site Bucuresti, Romania Research Site Cluj, Romania Research Site Constanta, Romania Research Site Craiova, Romania Research Site Galati, Romania Research Site Ghiroda, Romania Research Site Iasi, Romania Research Site Lugoj, Romania Research Site Oradea, Romania Research Site Pitesti, Romania Research Site Ploiesti, Romania Research Site Sibiu, Romania Research Site Timisoara, Romania Less << | |
NCT01766505 | Hypertension | Phase 4 | Terminated(lack of the subject... More >>s) Less << | - | Korea, Republic of ... More >> Chunbuk National University Hospital Chonju, Korea, Republic of, 561-712 Presbyterian Medical Center Chunju, Korea, Republic of, 560-750 Chungnam national university hospital Daejeon, Korea, Republic of, 301-721 The catholic university of Korea, Daejeon st. Mary's Hospital Daejeon, Korea, Republic of, 301-723 Eulji University Hospital Daejeon, Korea, Republic of, 302-799 Konyang university hospital Daejon, Korea, Republic of, 302-718 Chunnam National University Hospital Gwangju, Korea, Republic of, 501-757 Kwangju Christian Hospital Gwangju, Korea, Republic of, 503-715 ST.Carollo hospital Suncheon, Korea, Republic of, 540-719 Less << |
NCT02059616 | Essential Hypertension | Phase 2 | Unknown | December 2015 | Korea, Republic of ... More >> Seoul National University Bundang Hospital Recruiting Bundang, Korea, Republic of Dong-A University Hospital Recruiting Busan, Korea, Republic of Yeungnam University Medical Center Recruiting Daegu, Korea, Republic of Konyang University Hospital Recruiting Daejeon, Korea, Republic of Chonnam National University Hospital Recruiting Gwangju, Korea, Republic of Inje University Ilsan Paik Hospital Recruiting Ilsan, Korea, Republic of Inha University Hospital Recruiting Incheon, Korea, Republic of Hallym University Sacred Heart hospital Recruiting Kyungki-do, Korea, Republic of Inje University Haeundae Baik Hospital Recruiting Pusan, Korea, Republic of Pusan National University Hospital Recruiting Pusan, Korea, Republic of Asan Medical Center Recruiting Seoul, Korea, Republic of Ewha Womans University Mokdong Hospital Recruiting Seoul, Korea, Republic of Korea University Guro Hospital Recruiting Seoul, Korea, Republic of Seoul Medical Center Recruiting Seoul, Korea, Republic of Seoul St. Mary's hospital Recruiting Seoul, Korea, Republic of Severance Hospital Recruiting Seoul, Korea, Republic of Soonchunhyang University Hospital Recruiting Seoul, Korea, Republic of Yonsei University Gangnam Severance Hospital Recruiting Seoul, Korea, Republic of Ajou University Hospital Recruiting Suwon, Korea, Republic of Principal Investigator: Seung-Jea Tahk Wonju Severance Christian Hospital Recruiting Wonju, Korea, Republic of Less << |
NCT02521246 | Essential Arterial Hypertensio... More >>n Less << | Phase 3 | Withdrawn(Sponsor decision) | August 2017 | - |
NCT00459771 | Breast Cancer | Phase 3 | Completed | - | Netherlands ... More >> Medisch Centrum Alkmaar Alkmaar, Netherlands Flevoziekenhuis Almere, Netherlands The Netherlands Cancer Institute Amsterdam, Netherlands, 1066 CX Onze Lieve Vrouwe Gasthuis Amsterdam, Netherlands Slotervaart Hospital Amsterdam, Netherlands Wilhelmina Ziekenhuis Assen, Netherlands Jeroen Bosch Hospital Den Bosch, Netherlands Deventer Ziekenhuis Deventer, Netherlands Medisch Spectrum Twente Enschede, Netherlands Martini Ziekenhuis Groningen, Netherlands University Medical Center Groningen Groningen, Netherlands Ziekenhuis de Tjongerschans Heerenveen, Netherlands Medisch Centrum Leeuwarden Leeuwarden, Netherlands Antonius Ziekenhuis Nieuwegein, Netherlands Canisius-Wilhelmina Hospital Nijmegen, Netherlands UMC St. Radboud Nijmegen, Netherlands VieCuri Medisch Centrum voor Noord-Limburg Venlo, Netherlands Streekziekenhuis Koningin Beatrix Winterswijk, Netherlands Isala Klinieken Zwolle, Netherlands Less << |
NCT03231982 | Hypertension | Phase 4 | Recruiting | May 31, 2019 | Korea, Republic of ... More >> Yonsei University Severance Cardiovascular Hospital Recruiting Seoul, Korea, Republic of Contact: Donghoon Choi, M.D., Ph.D. 82-2-2228-8200 cdhlyj@yuhs.ac Less << |
NCT01135212 | Hypertension | Phase 3 | Completed | - | Korea, Republic of ... More >> KyungPook National University Hospital Daegu, Korea, Republic of, 110-750 Less << |
NCT02068495 | - | Completed | - | - | |
NCT02068495 | - | Completed | - | - | |
NCT00125463 | Hypertension ... More >>Cardiovascular Diseases Less << | Phase 3 | Unknown | - | Japan ... More >> Kyoto University Kyoto, Yoshidakonoe-cho, Sakyo-ku, Kyoto, Japan, 606-8501 Less << |
NCT00984529 | - | Completed | - | Croatia ... More >> Research Site Biograd, Croatia Research Site Bjelovar, Croatia Reserach Site Cakovec, Croatia Research Site Karlovac, Croatia Reserach Site Krapinske Toplice, Croatia Research Site Novi Marof, Croatia Research Site Opatija, Croatia Research Site Osijek, Croatia Research Site Pula, Croatia Research Site Rijeka, Croatia Reserach Site Sl. Brod, Croatia Research Site Split, Croatia Research Site Stubicke Toplice, Croatia Reserach Site Zabok, Croatia Research Site Zagreb, Croatia Less << | |
NCT02173912 | Healthy Volunteers | Phase 1 | Unknown | August 2014 | Korea, Republic of ... More >> Samsung Medical Center Recruiting Seoul, Korea, Republic of Contact: Chaeyeong Lee Principal Investigator: Jae-Wook Ko, MD Less << |
NCT02064556 | Hypertension | Phase 1 | Completed | - | Korea, Republic of ... More >> Asan Medical Center Seoul, Songpa-gu, Korea, Republic of Less << |
NCT00244621 | - | Completed | - | - | |
NCT00244621 | Hypertension | Phase 3 | Completed | - | - |
NCT00108706 | Cerebrovascular Accident|Acute... More >> Stroke Less << | PHASE4 | UNKNOWN | 2025-09-07 | Sunderland Royal Hospital, Sun... More >>derland, Tyne and Wear, SR4 7TP, United Kingdom Less << |
NCT00282178 | Hypertension ... More >>Obesity Less << | Phase 2 | Completed | - | Sweden ... More >> Umeå University Hospital Umeå, Sweden, SE-90185 Less << |
NCT00690612 | Hypertension | Phase 3 | Completed | - | Belgium ... More >> Research Site Edegem, Belgium Research Site Gent, Belgium France Research Site Strasbourg Cedex, France Germany Research Site Erlangen, Germany Research Site Heidelberg, Germany Research Site Marburg, Germany Research Site Rostock, Germany Italy Research Site Genova, GE, Italy Research Site Padova, PD, Italy Poland Research Site Gda�sk, Poland Research Site Krakow, Poland Ukraine Research Site Crimea, Ukraine Research Site Kyiv, Ukraine Less << |
NCT00608153 | - | Completed | - | - | |
NCT00884663 | Migraine Without Aura ... More >> Migraine With Aura Chronic Migraine Less << | Phase 2 Phase 3 | Completed | - | Norway ... More >> Norwegian National Headache Centre, St. Olavs University Hospital Trondheim, Norway, 7489 Less << |
NCT02548286 | Hypertension | Phase 1 | Completed | - | Korea, Republic of ... More >> Chungnam National University Hospital Daejeon, Jung-gu, Korea, Republic of Less << |
NCT00690612 | - | Completed | - | - | |
NCT00120003 | Stroke | Phase 3 | Completed | - | Norway ... More >> Ullevaal University Hospital Oslo, Norway, NO-0407 Less << |
NCT02651870 | Hypertension | Phase 3 | Unknown | February 2016 | Korea, Republic of ... More >> Severance Hospital Recruiting Seoul, Korea, Republic of Contact: Dong-Hoon Choi, M.D., Ph.D Principal Investigator: Dong-Hoon Choi, M.D, Ph.D Less << |
NCT00383929 | Hypertension | Phase 3 | Completed | - | - |
NCT00607633 | - | Completed | - | - | |
NCT02047019 | Hypertension | Phase 3 | Withdrawn(GPDC decided to term... More >>inate the study) Less << | December 8, 2019 | Italy ... More >> Fondazione Università G.D'Annunzio Chieti, Abruzzo, Italy, 66100 A.O.U. di Bologna Policlinico S.Orsola Malpighi Bologna, Emilia-Romagna, Italy, 40138 AAS 3 Friuli Alto Medio Collin Udine, Friuli-Venezia Giulia, Italy, 33038 Fondazione Salvatore Maugeri Pavia, Lombardia, Italy, 27100 IRCCS Ist Neurologico Mediterraneo Isernia, Molise, Italy, 86077 A.O.U. di Sassari Sassari, Sardegna, Italy, 07100 A.O.U. Pisana Pisa, Toscana, Italy, 56126 AULSS 07 Pieve Soligo Treviso, Veneto, Italy, 31029 Less << |
NCT02521233 | Essential Arterial Hypertensio... More >>n Less << | Phase 3 | Withdrawn(Sponsor decision) | August 2017 | - |
NCT02079506 | Healthy | Phase 1 | Completed | - | Korea, Republic of ... More >> Chungnam National University Hospital Jung-gu, Daejeon, Korea, Republic of, 301-721 Less << |
NCT00434967 | Hypertension | Phase 3 | Completed | - | Belgium ... More >> Research Site Dour, Belgium Research Site Gozée, Belgium Research Site Hasselt, Belgium Research Site Linkebeek, Belgium Research Site Marchovelette, Belgium Research Site Ronquières, Belgium Research Site Saint-Médard, Belgium Research Site Steenokkerzel, Belgium Latvia Research Site Daugavpils, Latvia Research Site Ogre, Latvia Research Site Riga, Latvia Malta Research Site Gozo, Malta Research Site Gwardiamangia, Malta Romania Research Site Arad, Romania Research Site Bucuresti, Romania Research Site Iasi, Romania Research Site Pitesti, Romania Research Site Ploiesti, Romania Research Site Targoviste, Romania Research Site Timisoara, Romania Russian Federation Research Site Moscow, Russian Federation Research Site St. Petersburg, Russian Federation Slovakia Research Site Bratislava, Slovakia Research Site Levice, Slovakia Research Site Lucenec, Slovakia Research Site Presov, Slovakia Research Site Sahy, Slovakia Less << |
NCT00573430 | - | Completed | - | - | |
NCT02944734 | Essential Hypertension | Phase 2 | Completed | - | Korea, Republic of ... More >> Catholic University of Korea Bucheon St. Mary's Hospital Wonmi-gu, Bucheon, Korea, Republic of Inje University Busan Paik Hospital Busanjin-gu, Busan, Korea, Republic of Pusan National University Hospital Seo-gu, Busan, Korea, Republic of Keimyung University Dongsan Medical Center Joong-gu, Daegu, Korea, Republic of Kyungpook National University Hospital Joong-gu, Daegu, Korea, Republic of Daegu Catholic University Medical Center Nam- gu, Daegu, Korea, Republic of Dongguk University Ilsan Hospital Ilsandong-gu, Goyang-si, Gyeoggi-do, Korea, Republic of Chonnam National University Hospital Dong-Gu, Gwangju, Korea, Republic of Catholic University of Korea Uijeongbu St. Mary's hospital Uijeongbu-si, Gyeoggi-do, Korea, Republic of Gachon University Gil Hospital Namdong-gu, Incheon, Korea, Republic of St. Carollo General Hospital Suncheon-si, Jeollanam-do, Korea, Republic of Wonju Severance Christian Hospital Wonju, Kangwon-Do, Korea, Republic of Catholic University of Korea St. Paul's Hospital Dongdaemun-gu, Seoul, Korea, Republic of KyungHee University Medical Center Dongdaemun-gu, Seoul, Korea, Republic of Hallym University Kangdong Sacred Heart Hospital Gangdong-gu, Seoul, Korea, Republic of Kyung Hee University Hospital at Gangdong Gangdong-Gu, Seoul, Korea, Republic of VHS( Veterans Medical Service) Medical Center Gangdong-gu, Seoul, Korea, Republic of Konkuk University Medical Center Gwangjin-gu, Seoul, Korea, Republic of Seoul National University Hospital Jongro-gu, Seoul, Korea, Republic of Catholic University of Korea Seoul St. Mary's Hospital Seocho-Gu, Seoul, Korea, Republic of Korea University Anam Hospital Seongbuk-Gu, Seoul, Korea, Republic of Catholic University of Korea Yeouido St. Mary's Hospital Yeongdeungpo-gu, Seoul, Korea, Republic of Ulsan University Hospital Dong-gu, Ulsan, Korea, Republic of Less << |
NCT00620178 | - | Completed | - | Sweden ... More >> Research Site Uppsala, Sweden Less << | |
NCT00434967 | - | Completed | - | - | |
NCT00905333 | Healthy | Phase 1 | Completed | - | Brazil ... More >> Research Site Itatiba, SP, Brazil Research Site Americana, Brazil Less << |
NCT00844324 | Hypertension | Phase 1 | Completed | - | United Kingdom ... More >> Research Site Harrow, United Kingdom Less << |
NCT02261116 | Healthy | Phase 4 | Completed | - | - |
NCT02016183 | - | Completed | - | - | |
NCT01152567 | - | Completed | - | - | |
NCT00573430 | Non-diabetic Nephropathy With ... More >>Hypertension Less << | Phase 4 | Completed | - | Korea, Republic of ... More >> Research Site Seoul, Korea, Republic of Less << |
NCT00843154 | Heart Failure | Phase 3 | Terminated(Insufficient enroll... More >>ment) Less << | - | - |
NCT00242346 | Proteinuria | Phase 3 | Completed | - | Canada, Alberta ... More >> Research Site Calgary, Alberta, Canada Research Site Edmonton, Alberta, Canada Canada, British Columbia Research Site Kelowna, British Columbia, Canada Research Site Vancouver, British Columbia, Canada Canada, Manitoba Research Site Winnipeg, Manitoba, Canada Canada, Newfoundland and Labrador Research Site St. John, Newfoundland and Labrador, Canada Canada, Nova Scotia Research Site Halifax, Nova Scotia, Canada Canada, Ontario Research Site Courtice, Ontario, Canada Research Site Kitchener, Ontario, Canada Research Site London, Ontario, Canada Research Site Mississauga, Ontario, Canada Research Site Oakville, Ontario, Canada Research Site Oshawa, Ontario, Canada Research Site Richmond Hill, Ontario, Canada Research Site Scarborough, Ontario, Canada Research Site Sudbury, Ontario, Canada Research Site Thunder Bay, Ontario, Canada Research Site Timmins, Ontario, Canada Research Site Toronto, Ontario, Canada Research Site Weston, Ontario, Canada Canada, Quebec Research Site Greenfield Park, Quebec, Canada Research Site Laval, Quebec, Canada Research Site Montreal, Quebec, Canada Research Site Quebec City, Quebec, Canada Research Site Ste-Foy, Quebec, Canada Canada, Saskatchewan Research Site Saskatoon, Saskatchewan, Canada Less << |
NCT02016183 | - | Completed | - | Japan ... More >> Tokyo, Japan Less << | |
NCT02368665 | Essential Hypertension | Phase 3 | Unknown | June 2016 | Korea, Republic of ... More >> Hallym University Sungsim Hospital Recruiting Anyang-si, Korea, Republic of Inje University Busan Baik Hospital Recruiting Busan, Korea, Republic of Inje University Haeundae Baik Hospital Recruiting Busan, Korea, Republic of Yeungnam University Medical Center Recruiting Daegu, Korea, Republic of Chonnam National University Hospital Recruiting Gwangju, Korea, Republic of Inje University Ilsan Baik Hospital Recruiting Ilsan, Korea, Republic of Inha University Hospital Recruiting Incheon, Korea, Republic of Seoul National University Bundang Hospital Recruiting Seongnam-si, Korea, Republic of Asan Medical Center Recruiting Seoul, Korea, Republic of Ewha Womans University Mokdong Hospital Recruiting Seoul, Korea, Republic of Gangbuk Samsung Hospital Recruiting Seoul, Korea, Republic of Korea University Anam Hospital Recruiting Seoul, Korea, Republic of Korea University Guro Hospital Recruiting Seoul, Korea, Republic of Seoul Medical Center Recruiting Seoul, Korea, Republic of Seoul St. Mary's Hospital Catholic University Recruiting Seoul, Korea, Republic of Soonchunhyang University Hospital Recruiting Seoul, Korea, Republic of Yonsei University Severance Hospital Recruiting Seoul, Korea, Republic of Ajou University Hospital Recruiting Suwon, Korea, Republic of Principal Investigator: Seungjae Tahk Wonju Severance Christian Hospital Recruiting Wonju, Korea, Republic of Less << |
NCT01788358 | Hypertension | Phase 3 | Completed | - | - |
NCT00634712 | Congestive Heart Failure | Phase 3 | Completed | - | - |
NCT01788358 | - | Completed | - | - | |
NCT00634400 | Congestive Heart Failure | Phase 3 | Completed | - | - |
NCT00227318 | Hypertension | Phase 3 | Completed | - | - |
NCT02969265 | Hypertension | Phase 3 | Withdrawn(Business reasons unr... More >>elated to product safety) Less << | July 26, 2018 | - |
NCT00400582 | Heart Failure | Phase 4 | Completed | - | Canada, Quebec ... More >> Montreal Heart Institute Montreal, Quebec, Canada, H1T 1C8 Less << |
NCT00634309 | Congestive Heart Failure | Phase 3 | Completed | - | - |
NCT00621153 | - | Completed | - | - | |
NCT00621153 | Stage II Hypertension | Phase 4 | Completed | - | Korea, Republic of ... More >> Research Site Seoul, Korea, Republic of Less << |
NCT00775814 | Obesity Hyper... More >>tension Less << | Phase 4 | Completed | - | Germany ... More >> Bad Dürrheim, Baden-Württemberg, Germany Balingen, Baden-Württemberg, Germany Deggingen, Baden-Württemberg, Germany Rottweil, Baden-Württemberg, Germany Spaichingen, Baden-Württemberg, Germany Ingolstadt, Bayern, Germany München, Bayern, Germany Passau, Bayern, Germany Schauenburg, Hessen, Germany Bocholt, Nordrhein-Westfalen, Germany Essen, Nordrhein-Westfalen, Germany Isselburg, Nordrhein-Westfalen, Germany Köln, Nordrhein-Westfalen, Germany Roetgen, Nordrhein-Westfalen, Germany Troisdorf, Nordrhein-Westfalen, Germany Wesseling, Nordrhein-Westfalen, Germany Roedersheim-Gronau, Rheinland-Pfalz, Germany Dresden, Sachsen, Germany Freital, Sachsen, Germany Machem, Sachsen, Germany Markkleeberg, Sachsen, Germany Wermsdorf, Sachsen, Germany Bad Segeberg, Schleswig-Holstein, Germany Berlin, Germany Less << |
NCT00775840 | Heart Failure | Phase 3 | Completed | - | Germany ... More >> Bad Friedrichshall, Baden-Württemberg, Germany Heidelberg, Baden-Württemberg, Germany Ludwigsburg, Baden-Württemberg, Germany Bad Homburg, Hessen, Germany Bad Nauheim, Hessen, Germany Darmstadt, Hessen, Germany Frankfurt, Hessen, Germany Giessen, Hessen, Germany Kassel, Hessen, Germany Limburg, Hessen, Germany Melsungen, Hessen, Germany Mühlheim, Hessen, Germany Wiesbaden, Hessen, Germany Nienburg, Niedersachsen, Germany Northeim, Niedersachsen, Germany Weyhe, Niedersachsen, Germany Essen, Nordrhein-Westfalen, Germany Gelsenkirchen, Nordrhein-Westfalen, Germany Gladbeck, Nordrhein-Westfalen, Germany Langenfeld, Nordrhein-Westfalen, Germany Paderborn, Nordrhein-Westfalen, Germany Siegen, Nordrhein-Westfalen, Germany Bad Kreuznach, Rheinland-Pfalz, Germany Neukirchen, Saarland, Germany Coswig, Sachsen-Anhalt, Germany Dresden, Sachsen, Germany Hartmannsdorf, Sachsen, Germany Leipzig, Sachsen, Germany Leisnig, Sachsen, Germany Machem, Sachsen, Germany Markkleeberg, Sachsen, Germany Riesa, Sachsen, Germany Wermsdorf, Sachsen, Germany Erfurt, Thüringen, Germany Jena, Thüringen, Germany Nordhausen, Thüringen, Germany Berlin, Germany Less << |
NCT00139386 | Hypertension|Coronary Artery D... More >>isease Less << | PHASE4 | COMPLETED | 2025-04-12 | Department of Cardiovascular M... More >>edicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, 860-8556, Japan Less << |
NCT02094924 | Hypertension | Phase 1 | Completed | - | India ... More >> GSK Investigational Site Hyderabad, India, 500 013 Less << |
NCT00252733 | - | Completed | - | - | |
NCT02254447 | Cardiovascular Disease | Phase 1 | Completed | - | India ... More >> GSK Investigational Site Hyderabad, India, 500 013 Less << |
NCT01012479 | Hypertension | Phase 4 | Completed | - | Germany ... More >> Berlin, Germany Blankenhain, Germany Dortmund, Germany Hamburg, Germany Köthen, Germany Löhne, Germany Nürnberg, Germany Remscheid, Germany Rodgau, Germany Stockach, Germany Wardenburg, Germany Weinheim, Germany Ukraine Ivano-Frankivsk, Ukraine Kharkiv, Ukraine Kiev, Ukraine Lviv, Ukraine Less << |
NCT00348686 | - | Completed | - | - | |
NCT00348686 | Hypertension ... More >>Left Ventricular Hypertrophy Less << | Phase 4 | Completed | - | Korea, Republic of ... More >> Research Site BuSan, Korea, Republic of Research Site CheonAn, Korea, Republic of Research Site CheongJu, Korea, Republic of Research Site Chunbuk, Korea, Republic of Research Site DaeGu, Korea, Republic of Research Site DaeJeon, Korea, Republic of Research Site Gyungsangnamdo, Korea, Republic of Research Site JeonJu, Korea, Republic of Research Site KwangJu, Korea, Republic of Research Site Pusan, Korea, Republic of Research Site Ulsan, Korea, Republic of Less << |
NCT01976572 | Hyperphosphatemia ... More >> Chronic Kidney Disease Less << | Phase 1 | Completed | - | United Kingdom ... More >> Covance Clinical Research Unit Ltd. Leeds, Springfield House Hyde Street, United Kingdom Less << |
NCT00252733 | Type 1 Diabetes | Phase 3 | Completed | - | Australia ... More >> Research Site Herston, Australia Research Site Perth, Australia Denmark Research Site Odense, Denmark Less << |
NCT01976572 | - | Completed | - | - | |
NCT01611077 | Hypertension | Phase 4 | Completed | - | Germany ... More >> Praxis Dr. Reimer Anderbeck, Germany, 38836 Praxis Dr. Heinz Bergisch-Gladbach, Germany, 51429 Praxis Dr. Zemmrich Berlin, Germany, 12043 St.-Josefs-Hospital Cloppenburg, Germany, 49661 Praxis Dr. Pohl Dresden, Germany, 01129 Praxis Dr. Koßler-Wiesweg Essen, Germany, 45138 Praxis Dr. Rövenich Frankfurt, Germany, 65929 Praxis Dr. Strzata Kapellendorf, Germany, 99510 Praxis Dr. Paschmionka Leipzig, Germany, 04316 Praxis Dr. Pitule Ludwigshafen, Germany, 67061 Praxis Dr. Loddo Rastede, Germany, 26180 Less << |
NCT00252694 | Type 2 Diabetes | Phase 3 | Completed | - | - |
NCT02186496 | Hypertension | Phase 1 | Completed | - | Korea, Republic of ... More >> Chungnam National University Hospital Daejeon, Chungcheongbuk-do, Korea, Republic of, 301-721 Less << |
NCT01227603 | Hypertension, Essential | Phase 1 | Completed | - | Germany ... More >> Köln, Nordrhein-Westfalen, Germany, 51063 Less << |
NCT00252720 | Type 1 Diabetes | Phase 3 | Completed | - | - |
NCT00252694 | - | Completed | - | - | |
NCT03688633 | Peripheral Neuropathy | Phase 2 | Not yet recruiting | June 1, 2021 | France ... More >> CHU Limoges Not yet recruiting Limoges, France, 87042 Contact: Laurent Magy, MD 05 55 05 65 68 laurent.magy@unilim.fr Less << |
NCT00699452 | Aortic Valve Stenosis | Phase 3 | Unknown | December 2014 | Finland ... More >> Division of Cardiology, Helsinki University Central Hospital Recruiting Helsinki, Finland, 00029 Contact: Markku Kupari, MD, PhD 358-9-4717-2441 markku.kupari@hus.fi Contact: Satu Helske, MD, PhD 358-9-681-411 satu.helske@wri.fi Principal Investigator: Markku Kupari, MD, PhD Less << |
NCT01827202 | Hypertension ... More >>Chronic Kidney Disease Proteinuria Less << | Phase 4 | Completed | - | Austria ... More >> Medical University of Vienna, Department of Internal Medicine III, Division of Nephrology and Dialysis Vienna, Austria, 1090 Less << |
NCT02006589 | Hypertension | Phase 1 | Completed | - | India ... More >> GSK Investigational Site Hyderabad, India, 500 013 Less << |
NCT02006602 | Hypertension | Phase 1 | Completed | - | India ... More >> GSK Investigational Site Hyderabad, India, 500 013 Less << |
NCT02368652 | Essential Hypertension | Phase 3 | Unknown | June 2016 | Korea, Republic of ... More >> Hallym University Sungsim Hospital Recruiting Anyang-si, Korea, Republic of Inje University Busan Baik Hospital Recruiting Busan, Korea, Republic of Inje University Haeundae Baik Hospital Recruiting Busan, Korea, Republic of Yeungnam University Medical Center Recruiting Daegu, Korea, Republic of Chonnam National University Hospital Recruiting Gwangju, Korea, Republic of Inje University Ilsan Baik Hospital Recruiting Ilsan, Korea, Republic of Inha University Hospital Recruiting Incheon, Korea, Republic of Seoul National University Bundang Hospital Recruiting Seongnam-si, Korea, Republic of Asan Medical Center Recruiting Seoul, Korea, Republic of Ewha Womans University Mokdong Hospital Recruiting Seoul, Korea, Republic of Gangbuk Samsung Hospital Recruiting Seoul, Korea, Republic of Korea University Anam Hospital Recruiting Seoul, Korea, Republic of Korea University Guro Hospital Recruiting Seoul, Korea, Republic of Seoul Medical Center Recruiting Seoul, Korea, Republic of Seoul St. Mary's Hospital Catholic University Recruiting Seoul, Korea, Republic of Soonchunhyang University Hospital Recruiting Seoul, Korea, Republic of Yonsei University Severance Hospital Recruiting Seoul, Korea, Republic of Ajou University Hospital Recruiting Suwon, Korea, Republic of Principal Investigator: Seungjae Tahk Wonju Severance Christian Hospital Recruiting Wonju, Korea, Republic of Less << |
NCT01629225 | Essential Hypertension | PHASE4 | UNKNOWN | 2025-07-15 | Department of Cardiology, Dapi... More >>ng Hospital, The Third Military Medical University, Chongqing, 400042, China Less << |
NCT02988362 | Hypertension | Phase 1 | Unknown | March 2017 | - |
NCT02811731 | Hypertension | Phase 1 | Completed | - | - |
NCT00679640 | Heart Failure|Cohort Study | COMPLETED | 2025-07-10 | Research Site, Mulhouse Cedex ... More >>1, Alsace, France|Research Site, Bordeaux, Aquitaine Nord, France|Research Site, Dax Cedex, Aquitaine Sud, France|Research Site, St Jean de Luz, Aquitaine Sud, France|Research Site, Tarbes, Aquitaine Sud, France|Research Site, Arras Cedex, Artois, France|Research Site, Bethune, Artois, France|Research Site, Besancon Cedex, Aube Franche Comte, France|Research Site, Langres Cedex, Aube Franche Comte, France|Research Site, Vesoul Cedex, Aube Franche Comte, France|Research Site, Clermont Ferrand, Auvergne Stephanois, France|Research Site, St Chamond, Auvergne Stephanois, France|Research Site, St Etienne, Auvergne Stephanois, France|Research Site, Caen Cedex 1, Basse Normandie, France|Research Site, Caen Cedex 4, Basse Normandie, France|Research Site, Granville Cedex, Basse Normandie, France|Research Site, Mayenne Cedex, Basse Normandie, France|Research Site, St Martin D Aubigny, Basse Normandie, France|Research Site, Valognes, Basse Normandie, France|Research Site, Dijon, Bourgogne, France|Research Site, Dole Cedex, Bourgogne, France|Research Site, Paray Le Monial Cedex, Bourgogne, France|Research Site, Semur En Auxois, Bourgogne, France|Research Site, Lannion Cedex, Bretagne Nord, France|Research Site, Rennes, Bretagne Nord, France|Research Site, Morlaix Cedex, Bretagne Sud, France|Research Site, Bry Sur Marne Cedex, Brie, France|Research Site, Meaux Cedex, Brie, France|Research Site, Meaux, Brie, France|Research Site, Savigny Sur Orge, Brie, France|Research Site, Beziers Cedex, Catalogne, France|Research Site, Beziers, Catalogne, France|Research Site, Perpignan, Catalogne, France|Research Site, Sete, Catalogne, France|Research Site, Epernay, Champagne Ardennes, France|Research Site, Chateau D Olonne, Charente, France|Research Site, Niort, Charente, France|Research Site, Poitiers Cedex, Charente, France|Research Site, Royan, Charente, France|Research Site, Annecy Le Vieux, Dauphine, France|Research Site, Annemasse, Dauphine, France|Research Site, Sallanches Cedex, Dauphine, France|Research Site, Nice, Esterel, France|Research Site, St Raphael, Esterel, France|Research Site, Hazebrouck, Flandres, France|Research Site, Lille Cedex, Flandres, France|Research Site, Wattrelos Cedex, Flandres, France|Research Site, Castelsarrasin, Gascogne, France|Research Site, Montauban, Gascogne, France|Research Site, Perigueux Cedex, Gascogne, France|Research Site, Perigueux, Gascogne, France|Research Site, Rouen, Haute Normandie, France|Research Site, Boulogne Billancourt Cedex, Hauts de Seine, France|Research Site, Arles, Languedoc, France|Research Site, Montpellier, Languedoc, France|Research Site, Nimes, Languedoc, France|Research Site, Rodez, Languedoc, France|Research Site, Villefranche de Rouergue, Languedoc, France|Research Site, Limoges, Limousin, France|Research Site, St Amand Montrond, Limousin, France|Research Site, St Yrieix La Perche, Limousin, France|Research Site, Nancy, Lorraine, France|Research Site, St Avold, Lorraine, France|Research Site, Bourgoin Jallieu, Lyonnais, France|Research Site, Bron Cedex, Lyonnais, France|Research Site, Gleize, Lyonnais, France|Research Site, Lyon Cedex 03, Lyonnais, France|Research Site, Rillieux La Pape Cedex, Lyonnais, France|Research Site, Cogolin, Maures Corse, France|Research Site, Hyeres, Maures Corse, France|Research Site, Toulon Cedex, Maures Corse, France|Research Site, Toulon, Maures Corse, France|Research Site, Castanet Tolosan, Midi Pyrenees, France|Research Site, Muret Cedex, Midi Pyrenees, France|Research Site, Paris Cedex 04, Paris Centre, France|Research Site, Paris Cedex 15, Paris Centre, France|Research Site, Paris, Paris Centre, France|Research Site, Aulnay Sous Bois, Paris Nord Est, France|Research Site, Montfermeil, Paris Nord Est, France|Research Site, Montreuil Cedex, Paris Nord Est, France|Research Site, Montreuil, Paris Nord Est, France|Research Site, Chateaubriant, Pays de Loire, France|Research Site, Nantes, Pays de Loire, France|Research Site, Amiens Cedex 3, Picardie, France|Research Site, Conde Sur L Escaut, Picardie, France|Research Site, Valenciennes Cedex, Picardie, France|Research Site, Allauch Cedex, Provence, France|Research Site, Marseille, Provence, France|Research Site, Rognac, Provence, France|Research Site, Salon de Provence Cedex, Provence, France|Research Site, Salon de Provence, Provence, France|Research Site, La Source, Sologne, France|Research Site, Montargis, Sologne, France|Research Site, Orleans, Sologne, France|Research Site, Tonnerre, Sologne, France|Research Site, Arpajon, Touraine, France|Research Site, Chambray Les Tours Cedex, Touraine, France|Research Site, Tours, Touraine, France|Research Site, Villiers Sur Orge, Touraine, France|Research Site, APT, Vallee Du Rhone, France|Research Site, Chateaurenard, Vallee Du Rhone, France|Research Site, Gap Cedex, Vallee Du Rhone, France|Research Site, Beauchamp, Vexin, France|Research Site, Beauvais Cedex, Vexin, France|Research Site, Cergy, Vexin, France|Research Site, Chelles, Vexin, France|Research Site, Creil Cedex 1, Vexin, France|Research Site, Pontoise, Vexin, France|Research Site, Sarcelles, Vexin, France|Research Site, Evecquemont, Yvelines, France|Research Site, Gennevilliers, Yvelines, France|Research Site, Maisons Laffitte, Yvelines, France Less << | |
NCT01806311 | Hypertension | Phase 1 | Completed | - | Korea, Republic of ... More >> Chungnam national university hospital,clinical trial center Daejeon, Chungcheongbul-do, Korea, Republic of, 301-721 Less << |
NCT00252720 | - | Completed | - | - | |
NCT02801526 | Hypertension | Phase 1 | Completed | - | - |
NCT03136666 | Clinical Pharmacology | Phase 1 | Completed | - | Germany ... More >> Wuppertal, Nordrhein-Westfalen, Germany, 42096 Less << |
NCT01926652 | Healthy | Phase 1 | Completed | - | Korea, Republic of ... More >> Chungnam national university hospital, clinical trial center Daejeon, Chungcheongbul-do, Korea, Republic of, 301-721 Less << |
NCT01984164 | Hypertension ... More >>Mild Cognitive Impairment Less << | Phase 3 | Active, not recruiting | December 15, 2018 | United States, Georgia ... More >> Emory Univeristy Atlanta, Georgia, United States, 30329 Less << |
NCT01350609 | Hypertension, Essential | Phase 1 | Completed | - | Germany ... More >> Berlin, Germany, 13353 Less << |
NCT01845272 | Healthy | Phase 1 | Unknown | August 2013 | - |
NCT01938664 | Cocaine Dependence | Phase 2 | Completed | - | United States, Texas ... More >> Michael E. DeBakey VA Medical Center Houston, Texas, United States, 77030 Less << |
NCT00990639 | Alcoholic Liver Disease | Phase 1 Phase 2 | Completed | - | Korea, Republic of ... More >> Yonsei University Wonju College of Medicine Wonju Christian Hospital Wonju, Kangwon-do, Korea, Republic of, 220-701 Less << |
NCT03460327 | Obesity, Morbid | RECRUITING | 2025-10-26 | St. Olavs University Hospital,... More >> Trondheim, Norway Less << | |
NCT02064621 | Hypertension | Phase 1 | Completed | - | Korea, Republic of ... More >> Asan Medical Center Seoul, Songpa-gu, Korea, Republic of Less << |
NCT02166697 | - | Completed | - | - | |
NCT02211638 | - | Completed | - | Japan ... More >> Osaka, Japan Less << | |
NCT02646982 | Mild Cognitive Impairment | Phase 2 | Recruiting | September 2021 | United States, Georgia ... More >> Emory University Recruiting Atlanta, Georgia, United States, 30322 Contact: Ihab Hajjar, MD 404-712-7250 ihajjar@emory.edu Principal Investigator: Ihab Hajjar, MD Wesley Woods Center Recruiting Atlanta, Georgia, United States, 30329 Contact: Ihab Hajjar, MD 404-712-7250 ihajjar@emory.edu Less << |
NCT02211638 | - | Completed | - | - | |
NCT02166697 | - | Completed | - | - | |
NCT01444833 | Hypertension | UNKNOWN | 2025-12-12 | Institute of Experimental Endo... More >>crinology, SAS, Bratislava, 833 06, Slovakia Less << | |
NCT05321875 | Cardiomyopathy, Dilated | PHASE3 | RECRUITING | 2026-06-02 | Hospital Universitario Puerta ... More >>de Hierro-Majadahonda, Majadahonda, Madrid, 28222, Spain Less << |
NCT05328635 | Post-Traumatic Headache|Post-C... More >>oncussion Syndrome Less << | COMPLETED | 2024-09-01 | Danish Headache Center, Glostr... More >>up, 2600, Denmark Less << | |
NCT00294775 | Aortic Valve Stenosis|Left Ven... More >>tricular Hypertrophy|Atrial Fibrillation Less << | PHASE3 | UNKNOWN | 2025-06-09 | Cardiology Department, Odense ... More >>University hospital, Odense, Fyn, 5000, Denmark Less << |
NCT04138316 | Migraine|Head Pain | COMPLETED | 2022-12-16 | Hospital Clínico Universitario... More >> Valladolid, Valladolid, 47003, Spain Less << | |
NCT04429633 | Cardiotoxicity|Breast Cancer|P... More >>revention|Adjuvant|Trastuzumab Less << | UNKNOWN | 2023-07-18 | Samsung Medical Center, Seoul,... More >> 06351, Korea, Republic of Less << | |
NCT00320970 | Diabetic Nephropathy|Hypertens... More >>ion Less << | COMPLETED | 2025-09-04 | Providence Medical Research Ce... More >>nter, Spokane, Washington, 99204, United States Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.27mL 0.45mL 0.23mL |
11.35mL 2.27mL 1.14mL |
22.70mL 4.54mL 2.27mL |
|
Dissolving Methods |
in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:
|