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Chemical Structure| 3140-73-6 Chemical Structure| 3140-73-6
Chemical Structure| 3140-73-6

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Product Details of Chlorodimethoxytriazine

CAS No. :3140-73-6
Formula : C5H6ClN3O2
M.W : 175.57
SMILES Code : COC1=NC(=NC(=N1)OC)Cl
MDL No. :MFCD00075607
InChI Key :GPIQOFWTZXXOOV-UHFFFAOYSA-N
Pubchem ID :18450

Safety of Chlorodimethoxytriazine

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H317-H318-H411
Precautionary Statements:P271-P261-P264-P270-P272-P280-P310-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P501
Class:9
UN#:3077
Packing Group:

Application In Synthesis of Chlorodimethoxytriazine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3140-73-6 ]

[ 3140-73-6 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 3140-73-6 ]
  • [ 926-39-6 ]
  • sulfuric acid mono-[2-(4,6-dimethoxy-[1,3,5]triazin-2-ylamino)-ethyl ester]; sodium-salt [ No CAS ]
  • 2
  • [ 3140-73-6 ]
  • [ 4089-07-0 ]
  • [ 263276-09-1 ]
YieldReaction ConditionsOperation in experiment
68% Intermediate 11 S-Ethyl 3-(4-hydroxyphenyl)-2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)amino]propionate A mixture of <strong>[4089-07-0]L-<strong>[4089-07-0]tyrosine ethyl ester hydrochloride</strong></strong> (0.50 g, 2.0 mmol) and DIPEA (0.74 ml, 4.4 mmol) in CH3CN (8 ml) was stirred at room temperature for 15 minutes and then 2-chloro-4,6-dimethoxy-1,3,5-triazine (0.43 g, 2.2 mmol) was added, and the reaction stirred overnight then concentrated in vacuo.. The residue was partitioned between EtOAc (50 ml) and NaHCO3 solution (50 ml).. The organic layer was washed with 10percent citric acid solution (50 ml), NaHCO3 solution (50 ml) and water (50 ml), dried (MgSO4) and concentrated in vacuo to give the title compound as a colourless gum (0.48 g, 68percent): deltaH (DMSO d6) 6.90 (2H, d), 6.65 (2H, d), 5.90 (1H, m), 4.90 (1H, m), 4.10 (2H, m), 3.95 (3H, s), 3.90 (3H, s), 3.10 (2H, m), 1.20 (3H, t, J 7.1 Hz); m/z (EI+, 70V) 349.
  • 3
  • [ 3140-73-6 ]
  • [ 106877-31-0 ]
  • C13H13F3N4O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With potassium carbonate; In tetrahydrofuran; at 70℃; for 4h; General procedure: 2-Chloro-4,6-dimethoxy-1,3,5-triazine (1 mmol) (2), substituted aniline (1 mmol)/heterocyclic amines (3) (1 mmol), anhydrous K2CO3 (2 mmol) were added in dry THF (5 mL) taken in a round bottom flask. The reaction mixture was refluxed at 70 C for 4 h. After completion of the reaction the product is confirmed on thin-layer chromatography (TLC) using eluent (2:8 mL,ethyl acetate-hexane). The reaction mixture was quenched with water and the crude product was extracted with ethyl acetate (3 times) and organic layer was separated and dried over anhydrous Na2SO4. The solvent evaporated on rotavapour. The Crude material was purified by column chromatography (ethylacetate-n-hexane) and product 4(a-x) with good yield (70-75 %) were obtained (Scheme-II).
  • 4
  • [ 3140-73-6 ]
  • [ 2339-58-4 ]
  • C12H13FN4O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With potassium carbonate; In tetrahydrofuran; at 70℃; for 4h; General procedure: 2-Chloro-4,6-dimethoxy-1,3,5-triazine (1 mmol) (2), substituted aniline (1 mmol)/heterocyclic amines (3) (1 mmol), anhydrous K2CO3 (2 mmol) were added in dry THF (5 mL) taken in a round bottom flask. The reaction mixture was refluxed at 70 C for 4 h. After completion of the reaction the product is confirmed on thin-layer chromatography (TLC) using eluent (2:8 mL,ethyl acetate-hexane). The reaction mixture was quenched with water and the crude product was extracted with ethyl acetate (3 times) and organic layer was separated and dried over anhydrous Na2SO4. The solvent evaporated on rotavapour. The Crude material was purified by column chromatography (ethylacetate-n-hexane) and product 4(a-x) with good yield (70-75 %) were obtained (Scheme-II).
  • 5
  • [ 3140-73-6 ]
  • [ 40230-24-8 ]
  • N-(4,6-diphenylpyrimidin-2-yl)-4,6-dimethoxy-1,3,5-triazin-2-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
In acetone; for 8h;Reflux; 4,6-Diphenylpyrimidin-2-amine (0.01 mol) and 2-chloro-4,6- dimethoxy-1,3,5-triazine (0.01 mol) were taken in round bottom flask and dissolved in dry acetone (50 mL). The reaction mixture was refluxed for 8 h. After checking the TLC, the reaction mixture was poured into ice-cold water. Neutralization of HCl was done by sodium carbonate solution (0.005 N, 10 mL water). The solid was filtered, washed and dried. Spectral data for compound 3: The IR of compound 3 exhibited nu(N-H) = 3500-3300 cm-1 (N-H str. due to 2 amines), nu(C=C) =1633.76 cm-1 (-C=C- str. in aromatic ring), nu(C-O-C)stretching = 1222.91 cm-1 (C-O-C in ether), nu(C-N) stretching= 802.41 cm-1, nu(C-H)(sp2) stretching = 3150-2950; 1H NMR (400 MHz, DMSO-d6) delta ppm: 3.33 (s, 6H, -2OCH3), 6.5 (s,1H (C-H), pyrimidine ring), 7.38-7.42 (m, 10H, Ar-H).
 

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