CAS No. :	130-26-7
Formula :	C₉H₅ClINO
M.W :	305.50
SMILES Code :	OC1=C(I)C=C(Cl)C2=C1N=CC=C2
Synonyms :	Iodochlorohydroxyquinoline; Iodochlorohydroxyquin; NSC 74938
MDL No. :	MFCD00006787
InChI Key :	QCDFBFJGMNKBDO-UHFFFAOYSA-N
Pubchem ID :	2788

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H361-H317
Precautionary Statements:	P501-P261-P270-P202-P201-P264-P280-P272-P308+P313-P337+P313-P305+P351+P338-P302+P352-P333+P313-P362-P301+P312+P330-P405

OPM2	20 µM	24 hours	Induced LC3-II expression, indicating autophagosome formation	Sci Rep. 2014 Jul 18;4:5749.
RPMI-8226	20 µM	24 hours	Induced LC3-II expression, indicating autophagosome formation	Sci Rep. 2014 Jul 18;4:5749.
K562	20 µM	24 hours	Induced LC3-II expression, indicating autophagosome formation	Sci Rep. 2014 Jul 18;4:5749.
LP1	10, 20, 30 µM	24 hours	Induced LC3-II expression, indicating autophagosome formation	Sci Rep. 2014 Jul 18;4:5749.
THP-1	20 µM	24 hours	Induced LC3-II expression, indicating autophagosome formation	Sci Rep. 2014 Jul 18;4:5749.
OCI-AML2	20 µM	24 hours	Induced LC3-II expression, indicating autophagosome formation	Sci Rep. 2014 Jul 18;4:5749.
Human cervical cancer (HeLa) cells	50 µM	16 hours	CQ treatment increased total H3K4me3, H3K9me3, and H3K27me3	iScience. 2022 Jun 3;25(7):104517.
Human adipocyte-derived stem cells (hADSCs)	25 µM and 50 µM	16 hours	CQ treatment increased total H3K4me3, H3K9me3, and H3K27me3	iScience. 2022 Jun 3;25(7):104517.
Yeast cells	0.6 µM	16 hours	Clioquinol significantly reduced the accumulation of Aβ, and this effect was dependent on metal binding.	Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4013-8.
DRG neurons	3 µM	20 seconds	To investigate the effect of CQ in DRG neurons, results showed that CQ activated Ca2+ influx via TRPA1.	Proc Natl Acad Sci U S A. 2009 May 19;106(20):8374-9.
MCF10A	20 µM	24 hours	To test the proteasome inhibition and apoptosis induction effects of Clioquinol mixed with copper on normal and malignant breast cells. Results showed that Clioquinol mixed with copper had significant inhibitory effects on malignant cells but no effect on normal cells.	Breast Cancer Res. 2005;7(6):R897-908.
MDA-MB-231	20 µM	24 hours	To test the proteasome inhibition and apoptosis induction effects of Clioquinol mixed with copper on breast cancer cells. Results showed that Clioquinol mixed with copper significantly inhibited proteasome activity and induced apoptosis.	Breast Cancer Res. 2005;7(6):R897-908.
HUVECs	2.5, 5, 10 µM	24 hours	Assessed cell proliferation, showing dose-dependent inhibition	Angiogenesis. 2025 Feb 3;28(2):13.
M1C cells	5 µM	24 hours	To evaluate the effect of CQ on tau protein levels. Results showed that 5 µM CQ significantly reduced tau protein levels detected by non-phospho dependent Tau5	Int J Mol Sci. 2021 Nov 8;22(21):12063.
M1C cells	1 µM	24 hours	To evaluate the effect of CQ on intracellular Cu+ levels. Results showed that 1 µM CQ significantly reduced intracellular Cu+ levels	Int J Mol Sci. 2021 Nov 8;22(21):12063.
M1C cells	0.1 to 10 µM	24 hours	To evaluate the effect of CQ on cell viability. Morphological analysis and ATP assay showed that CQ up to 10 µM had no effect on cell viability, but 100 µM CQ was cytotoxic	Int J Mol Sci. 2021 Nov 8;22(21):12063.
HL-1 cardiomyocytes	80 μg/ml	24 hours	Evaluate the inhibitory effect of Clioquinol on ISO-induced ferroptosis in HL-1 cardiomyocytes. Results showed that Clioquinol significantly inhibited ISO-induced ferroptosis in HL-1 cardiomyocytes.	Front Pharmacol. 2022 Jul 22;13:918292.
HL-1 cardiomyocytes	0, 10, 20, 40, 60, 80, 100 μg/ml	24 hours	Evaluate the cytotoxicity of Clioquinol on HL-1 cardiomyocytes. Results showed that when the concentration of Clioquinol was 60–100 μg/ml, HL-1 cells exhibited significant cytotoxicity.	Front Pharmacol. 2022 Jul 22;13:918292.
HEK293 cells	0, 1, 5, 6, 8, 10 µM	24 hours	To evaluate the effect of CQ on lipid peroxidation. CQ increased lipid peroxidation in HEK293 cells, while the antioxidants NAC and Trolox significantly reduced CQ-induced lipid peroxidation.	Front Pharmacol. 2022 Oct 4;13:1000278.
HepG2 cells	0, 1, 2, 3, 4, 5, 10 µM	24 hours	To evaluate the effect of CQ on ATP levels. Only at the highest concentrations, a small but significant reduction of ATP was detected in both media.	Front Pharmacol. 2022 Oct 4;13:1000278.
SK-N-SH cells	5 µM	24 hours	Clioquinol at low dose increased cell viability and reversed cell death caused by MPP+ or H2O2, reducing apoptosis and ROS levels.	Aging (Albany NY). 2020 May 18;12(10):9515-9533.
HEK293 cells	0.5–8 µM	30 minutes	Reduced mutant protein expression and cell death	Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11840-5.
PC12 cells	4 µM	48 hours	Reduced mutant protein accumulation and cell death	Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11840-5.
HDMECs	10 µM	48 hours	Assessed cell viability, showing selective and significant reduction	Angiogenesis. 2025 Feb 3;28(2):13.
HUVECs	10 µM	48 hours	Assessed cell viability, showing selective and significant reduction	Angiogenesis. 2025 Feb 3;28(2):13.
CNE-2s cells	1 µM	6 hours	Enhanced radiosensitivity of CNE-2s cells through autophagy inhibition, activation of the caspase system and impairment of DNA damage repair	Int J Biol Sci. 2020 Jan 14;16(5):777-789.
Yeast cells	0.8 µM	7 hours	Clioquinol promotes Aβ degradation through a metal-dependent mechanism, reducing Aβ levels and restoring functional vesicle trafficking	ACS Chem Neurosci. 2017 Sep 20;8(9):2039-2055.
A2780 cells	13.00±2.1 µM (IC50)	72 hours	Compare the cytotoxicity of clioquinol and its analogues, IC50 value was 13.00±2.1 μM	Cancer Lett. 2011 Dec 15;312(1):11-7.
Panc-1 cells	5.89±0.28 µM (IC50)	72 hours	Compare the cytotoxicity of clioquinol and its analogues, IC50 value was 5.89±0.28 μM	Cancer Lett. 2011 Dec 15;312(1):11-7.
DHL-4 cells	2.71±0.18 µM (IC50)	72 hours	Compare the cytotoxicity of clioquinol and its analogues, IC50 value was 2.71±0.18 μM	Cancer Lett. 2011 Dec 15;312(1):11-7.
HL-60 cells	12.90±0.16 µM (IC50)	72 hours	Compare the cytotoxicity of clioquinol and its analogues, IC50 value was 12.90±0.16 μM	Cancer Lett. 2011 Dec 15;312(1):11-7.
Raji cells	5.09±0.20 µM (IC50)	72 hours	Compare the cytotoxicity of clioquinol and its analogues, IC50 value was 5.09±0.20 μM	Cancer Lett. 2011 Dec 15;312(1):11-7.
CHO cells	10 µM		To investigate whether CQ directly activates TRPA1, results showed that CQ evoked currents in CHO cells via TRPA1 activation.	Proc Natl Acad Sci U S A. 2009 May 19;106(20):8374-9.
Human glioblastoma (U87)	50 µM		CQ treatment increased total H3K4me3, H3K9me3, and H3K27me3	iScience. 2022 Jun 3;25(7):104517.

Caenorhabditis elegans	Glutamatergic neuron-specific Aβ expression model	Soaking administration	0.125-0.25 μM	24-hour treatment followed by 4-day observation	Clioquinol synergizes with DHPM-thiones to significantly protect Aβ-expressing glutamatergic neurons from toxicity	ACS Chem Neurosci. 2017 Sep 20;8(9):2039-2055.
Caenorhabditis elegans	Glutamatergic neuron model expressing Aβ	Acute administration	0.5 μM, 1 μM, 2 μM	Single dose, transferred to normal media after 24 hours	Clioquinol significantly reduced Aβ-induced neuronal loss and improved the survival rate of the worms.	Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4013-8.
BALB/c mice	Matrigel plug assay	Subcutaneous injection	10 µM	7 days	Assessed blood vessel formation, showing a 43% reduction in microvessel density	Angiogenesis. 2025 Feb 3;28(2):13.
BALB/C nu/nu mice	CNE-2s cell xenograft model	Intraperitoneal injection	10 mg/kg	Once every other day for one week	CQ combined with zinc significantly enhanced the radiosensitivity of CNE-2s cells and inhibited tumor growth	Int J Biol Sci. 2020 Jan 14;16(5):777-789.
Rhesus monkeys (Macaca mulatta lasiotis)	MPTP-induced Parkinson’s disease model	Oral	10 mg/kg	Twice daily for four weeks	Clioquinol significantly improved motor and non-motor deficits induced by MPTP, reduced iron content and ROS levels in the SN, improved pathology, and activated the AKT/mTOR pathway.	Aging (Albany NY). 2020 May 18;12(10):9515-9533.
Mice	Wild-type and TRPA1-deficient mice	Intraplantar injection	2.5 nmoles	Single injection, observed for 4 hours	To investigate the acute nociceptive effects of CQ in mice, results showed that CQ caused mechanical hyperalgesia and cold hypersensitivity via TRPA1.	Proc Natl Acad Sci U S A. 2009 May 19;106(20):8374-9.
C57BL/6 mice	Diabetic wound model	Local injection	4 μg/wound	Dressing changed on postoperative days 3 and 6	To evaluate the efficacy of EXOsiFDX1-PDA@CQ in diabetic wound models. Results showed that EXOsiFDX1-PDA@CQ significantly promoted wound healing, reduced Cu content, and inhibited FDX1 expression.	Adv Sci (Weinh). 2025 Jan;12(4):e2413408
C57BL/6 mice	MSU-induced acute peritonitis	Intraperitoneal injection	5 mg/kg or 10 mg/kg	Every 12 hours for 24 hours	To evaluate the therapeutic effect of CQ on MSU-induced acute peritonitis, results showed that CQ significantly reduced the frequency and number of white blood cells, neutrophils, and monocytes, and decreased the release of IL-1β, IL-6, and TNF-α.	J Pharm Anal. 2025 Jan;15(1):101069

NCT00943748	Parkinson's Disease	Phase 2 Phase 3	Completed	-	France ... More >> Service de Neurologie, Clinique Neurologique, EA 2683, IFR 114 Lille, France, 59037 Less <<
NCT01429701	Eczema	Phase 3	Completed	-	-
NCT00963495	Acute Myeloid Leukemia\|Acute L... More >>ymphocytic Leukemia\|Chronic Lymphocytic Leukemia\|Myelodysplasia\|Lymphoma, Non-Hodgkin\|Hodgkin's Lymphoma\|Multiple Myeloma Less <<	PHASE1	TERMINATED	2025-09-13	Princess Margaret Hospital, To... More >>ronto, Ontario, M5G 2M9, Canada Less <<
NCT05727943	Epilepsy Intractable	PHASE2	UNKNOWN	2023-12-31	University Hospitals UZ Leuven... More >>, Leuven, 3000, Belgium Less <<

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CAS No.: 130-26-7

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CAS No.: 130-26-7

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed