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Chemical Structure| 1224606-06-7 Chemical Structure| 1224606-06-7
Chemical Structure| 1224606-06-7

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D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

Synonyms: MC3

4.5 *For Research Use Only !

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Product Citations

Product Citations

Lambart, Izabella ; Zaryouh, Hannah ; Van Audenaerde, Jonas ; Liu, Dana ; Quatannens, Delphine ; Lion, Eva , et al.

Abstract: The use of mRNA as a therapeutic drug class is a safe and fast alternative to viral vector or plasmid DNA therapies. Nevertheless, free mRNA will be rapidly degraded after administration to the body and only reach the cytosol of desired cells with difficulty. Lipid nanoparticles (LNP) safely deliver mRNA to cells of interest and can be used in the treatment of different diseases. Dendritic cells are the primary antigen-presenting cells and important for mRNA vaccine delivery. Efforts to increase LNP transfection of these cells are necessary and can be achieved by different approaches. Here, we present apolipoprotein E4 addition to LNP administration as one mean of increasing LNP-mediated eGFP mRNA delivery to dendritic cells. We also show some steps in the preparation method for LNP optimization using MS2 RNA as a novel model nucleic acid.

Keywords: Lipid nanoparticles ; eGFP mRNA ; MS2 RNA ; dendritic cell ; transfection ; apolipoprotein ; electroporation

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Product Details of D-Lin-MC3-DMA

CAS No. :1224606-06-7
Formula : C43H79NO2
M.W : 642.09
SMILES Code : O=C(OC(CCCCCCCC/C=C\C/C=C\CCCCC)CCCCCCCC/C=C\C/C=C\CCCCC)CCCN(C)C
Synonyms :
MC3
MDL No. :MFCD31657426
InChI Key :NRLNQCOGCKAESA-KWXKLSQISA-N
Pubchem ID :49785164

Safety of D-Lin-MC3-DMA

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of D-Lin-MC3-DMA

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

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