Structure of Dapagliflozin
CAS No.: 461432-26-8
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Dapagliflozin (BMS-512148), a new agent for treating diabetes mellitus (DM), is a competitive inhibitor of sodium/glucose cotransporter 2 (SGLT2), leading to glucose excretion in the urine. Dapagliflozin induces HIF1 expression and reduces renal IR injury.
Synonyms: BMS-512148
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Ahasanul Hasan ; Sreelakshmi N. Menon ; Farzana Zerin ; Raquibul Hasan ;
Abstract: Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that, in addition to glucose reduction, lowers systemic blood pressure. Here, we investigated if dapagliflozin could directly relax small mesenteric arteries that control peripheral vascular resistance and blood pressure, and the underlying molecular mechanism. We used pressurized arterial myography, pharmacological inhibition and Western blotting to investigate the direct effect of dapagliflozin on the contractility of freshly isolated, resistance-size rat mesenteric arteries. Our pressure myography data unveiled that dapagliflozin relaxed small mesenteric arteries in a concentration-dependent manner. Non-selective inhibition of KV channels and selective inhibition of smooth muscle cell voltage-gated K+ channels KV7 attenuated dapagliflozin-induced vasorelaxation. Inhibition of other major KV isoforms such as KV1.3, KV1.5 channels as well as large-conductance Ca2+-activated K+ (BKCa) channels, ATP-sensitive (KATP) channels did not abolish vasodilation. Dapagliflozin-evoked vasodilation remained unaltered by pharmacological inhibition of endothelium-derived nitric oxide (NO) signaling, prostacyclin (PGI2), as well as by endothelium denudation. Our Western blotting data revealed that SGLT2 protein is expressed in rat mesenteric arteries. However, non-selective inhibition of SGLTs did not induce vasodilation, demonstrating that the vasodilatory action is independent of SGLT2 inhibition. Overall, our data suggests that dapagliflozin directly and selectively stimulates arterial smooth muscle cells KV7 channels, leading to vasodilation in resistance-size mesenteric arteries. These findings are significant as it uncovers for the first time a direct vasodilatory action of dapagliflozin in resistance mesenteric arteries, which may lower systemic blood pressure.
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Keywords: Dapagliflozin ; Vascular resistance ; Mesenteric arteries ; Vasodilation ; Voltage-gated K+ channels
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CAS No. : | 461432-26-8 |
Formula : | C21H25ClO6 |
M.W : | 408.87 |
SMILES Code : | ClC(C=CC([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)=C2)=C2CC3=CC=C(OCC)C=C3 |
Synonyms : |
BMS-512148
|
MDL No. : | MFCD13182359 |
InChI Key : | JVHXJTBJCFBINQ-ADAARDCZSA-N |
Pubchem ID : | 9887712 |
GHS Pictogram: |
![]() ![]() ![]() |
Signal Word: | Danger |
Hazard Statements: | H302-H319-H372-H411 |
Precautionary Statements: | P260-P264-P270-P273-P280-P301+P312+P330-P305+P351+P338-P314-P337+P313-P391-P501 |
Class: | 9 |
UN#: | 3077 |
Packing Group: | Ⅲ |
Target |
|
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02096705 | Diabetes | Phase 3 | Completed | - | - |
NCT03565458 | Type 2 Diabetes Mellitus | Phase 1 | Active, not recruiting | December 22, 2018 | Korea, Republic of ... More >> LG chem Seoul, Gangseo-Gu, Korea, Republic of, 07795 Less << |
NCT02096705 | - | Completed | - | - | |
NCT00831779 | Type 2 Diabetes Mellitus | Phase 2 | Completed | - | United States, California ... More >> Va San Diego Healthcare System San Diego, California, United States, 92161 United States, Louisiana Pennington Biomedical Research Center Baton Rouge, Louisiana, United States, 70808 United States, Pennsylvania Temple University General Clinical Research Center Philadelphia, Pennsylvania, United States, 19140 Less << |
NCT02419612 | - | Active, not recruiting | - | - | |
NCT00831779 | - | Completed | - | - | |
NCT02419612 | Diabetes | Phase 3 | Active, not recruiting | August 15, 2019 | - |
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NCT01137474 | Type 2 Diabetes | Phase 3 | Completed | - | - |
NCT00736879 | Type 2 Diabetes Mellitus | Phase 3 | Completed | - | - |
NCT01525238 | - | Completed | - | - | |
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NCT02520518 | - | Terminated(Designed a new modi... More >>fied/simplified protocol see NCT 03180489) Less << | - | - | |
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NCT02551874 | Type 2 Diabetes Mellitus | Phase 3 | Completed | - | - |
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NCT02551874 | - | Completed | - | - | |
NCT02229396 | Diabetes Mellitus | Phase 3 | Completed | - | - |
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NCT02229396 | - | Completed | - | - | |
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NCT02235298 | Type 2 Diabetes | Phase 4 | Recruiting | December 2019 | United States, Florida ... More >> University of Miami Recruiting Miami, Florida, United States, 33136 Contact: Gianluca Iacobellis, MD PhD giacobellis@med.miami.edu Principal Investigator: Gianluca Iacobellis, MD PhD University of Miami Recruiting Miami, Florida, United States, 33136 Contact: Gianluca Iacobellis, MD PhD giacobellis@med.miami.edu Less << |
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NCT01392677 | Type 2 Diabetes Mellitus ... More >> High HbA1c Level Inadequate Glycaemic Control Less << | Phase 3 | Completed | - | - |
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NCT00984867 | Type 2 Diabetes | Phase 3 | Completed | - | - |
NCT02700334 | Prediabetes I... More >>mpaired Fasting Glucose Impaired Glucose Tolerance Less << | Phase 4 | Completed | - | Mexico ... More >> Intstituto de Terapeútica Experimental y Clínica. Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara Guadalajara, Jalisco, Mexico, 44340 Less << |
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NCT03316131 | Asymptomatic Hyperuricemia | Phase 2 | Completed | - | United States, California ... More >> Research Site Glendale, California, United States, 91206 United States, Maryland Research Site Baltimore, Maryland, United States, 21225 Less << |
NCT02682563 | Diabetes Mellitus, Type 2 ... More >> Diabetic Nephropathies Less << | Phase 4 | Completed | - | Netherlands ... More >> VU University Medical Center Amsterdam, Noord-Holland, Netherlands, 1081 HV Less << |
NCT03036124 | Chronic Heart Failure With Red... More >>uced Ejection Fraction (HFrEF) Less << | Phase 3 | Active, not recruiting | December 4, 2019 | - |
NCT02383238 | Diabetes Mellitus Type 2 | Phase 3 | Completed | - | Germany ... More >> University Erlangen-Nuernberg Erlangen, Germany, 91054 Less << |
NCT02616666 | Type 2 Diabetes Mellitus | Phase 4 | Recruiting | December 31, 2021 | - |
NCT03704818 | Type1 Diabetes Mellitus | Phase 1 | Recruiting | December 31, 2020 | United States, California ... More >> UC San Diego Altman Clinical & Translational Research Institute Recruiting La Jolla, California, United States, 92037 Contact: Todd May, MS tmay@ucsd.edu Less << |
NCT02887677 | Diabetes Mellitus | Phase 4 | Recruiting | December 2019 | Greece ... More >> Ahepa Hospital Recruiting Thessaloniki, Greece, 54621 Contact: Kalliopi Kotsa +306932045201 kalli@med.auth.gr Sub-Investigator: Elena Aggeloudi Hippokrateio Hospital Recruiting Thessaloniki, Greece, 54642 Contact: Asterios Karagiannis +306972011271 astkar@med.auth.gr Sub-Investigator: Eirini Papadopoulou Sub-Investigator: Athanasios Binas Sub-Investigator: Alexia Piperidou Papageorgiou Hospital Recruiting Thessaloniki, Greece, 56429 Contact: Glyceria Tzatzagou 2313323165 tzatzagougl@hotmail.gr Sub-Investigator: Despoina Kosmidou Sub-Investigator: Eleonora Kella Less << |
NCT03036150 | Chronic Kidney Disease | Phase 3 | Recruiting | November 27, 2020 | - |
NCT02371187 | Physical Activity | Phase 2 | Completed | - | United States, Colorado ... More >> Colorado State University, Dept. of Health and Exercise Science Fort Collins, Colorado, United States, 80523-1582 Less << |
NCT01156246 | Healthy | Phase 1 | Completed | - | Sweden ... More >> Research Site Lulea, Sweden Less << |
NCT02919345 | Diabetes Mellitus, Type 2 ... More >> Coronary Artery Disease Carotid Artery Diseases Less << | Phase 4 | Unknown | October 2017 | Brazil ... More >> State University of Campinas Campinas, Sao Paulo, Brazil, 13083-887 Less << |
NCT03377335 | Type 2 Diabetes Mellitus | Phase 4 | Active, not recruiting | January 2019 | Italy ... More >> University Hospital of Palermo Palermo, Italy, 90127 Less << |
NCT02211742 | Fasting Glucose|Glucose Excurs... More >>ion|Glycemic Control Less << | PHASE4 | COMPLETED | 2017-02-08 | Medical University Innsbruck, ... More >>Department of Internal Medicine I, Innsbruck, Tirol, 6020, Austria Less << |
NCT02608905 | Type 2 Diabetes Mellitus | Phase 4 | Recruiting | May 2019 | United States, Texas ... More >> Baylor College of Medicine Recruiting Houston, Texas, United States, 77030 Contact: Mandeep Bajaj, MD 713-798-1712 bajaj@bcm.edu Less << |
NCT02426541 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | Finland ... More >> Research Site Turku, Finland Less << |
NCT03180489 | Weight Loss | Phase 2 | Recruiting | May 2019 | United States, Colorado ... More >> Colorado State University, Dept. of Health and Exercise Science Recruiting Fort Collins, Colorado, United States, 80523-1582 Contact: Christopher Bell, PhD 970-491-7522 Christopher.Bell@colostate.edu Contact: Laurie M Biela, BS 970-491-2242 Laurie.Biela@colostate.edu Principal Investigator: Christopher Bell, PhD Principal Investigator: Christopher Melby, Dr.P.H. Less << |
NCT03074630 | Diabetes Mellitus, Type 2 ... More >> Hypercholesterolemia Less << | Phase 4 | Completed | - | Netherlands ... More >> Academic Medical Center Amsterdam, North Holland, Netherlands, 1105AZ Less << |
NCT02981966 | Diabetes Mellitus, Type 2 | Phase 4 | Not yet recruiting | January 2021 | United States, Texas ... More >> University of Texas Health Science Center San Antonio, Texas, United States, 78229 Less << |
NCT02426541 | - | Completed | - | - | |
NCT02577159 | Diabetes Mellitus, Type 2 | PHASE4 | UNKNOWN | 2018-08-31 | Sousei Hospital, Kadoma, Osaka... More >>, 5710025, Japan|Osaka Central Hospital, Osaka city, Osaka, 5300001, Japan|Osaka University Hospital, Suita, Osaka, 5650871, Japan Less << |
NCT02973477 | Type2 Diabetes ... More >> Cardiovascular Diseases Less << | Phase 4 | Recruiting | February 2020 | United States, Michigan ... More >> University of Michigan Recruiting Ann Arbor, Michigan, United States, 48104 Contact: Jacob E Reiss, B.S. 734-763-0177 jereiss@med.umich.edu Principal Investigator: Lynn Ang, M.D. Principal Investigator: Rodica Pop-Busui, M.D., Ph.D. Less << |
NCT03423355 | Type 2 Diabetes Mellitus (T2DM... More >>) Less << | Phase 4 | Not yet recruiting | March 31, 2020 | Germany ... More >> Technical University Dresden University Hospital Carl Gustav Carus Not yet recruiting Dresden, Germany, 01307 Contact: Andreas Birkenfeld, Prof. Dr. +49 (0) 351 458 13651 ext 13651 andreas.birkenfeld@uniklinikum-dresden.de Less << |
NCT02413398 | Type 2 Diabetes Mellitus | Phase 3 | Completed | - | - |
NCT02413398 | - | Completed | - | - | |
NCT02585804 | Focal Segmental Glomeruloscler... More >>osis Less << | PHASE4 | COMPLETED | 2017-04-24 | Renal Physiology Laboratory, U... More >>niversity Health Network, Toronto, Ontario, M5G 2N2, Canada Less << |
NCT02653482 | Chronic Heart Failure With Red... More >>uced Systolic Function Less << | Phase 4 | Recruiting | April 2019 | - |
NCT03721874 | Prediabetic State ... More >> Substrate Oxidation Less << | Phase 4 | Not yet recruiting | January 2020 | Netherlands ... More >> Maastricht University and Medical Centre Not yet recruiting Maastricht, Limburg, Netherlands, 6200 MD Less << |
NCT02919059 | Diabetes Mellitus, Type 2 | Phase 4 | Recruiting | August 2019 | Spain ... More >> Hospital Nuestra Señora de la Esperanza Recruiting Santiago de Compostela, Galicia, Spain, 15705 Contact: Álvaro Hermida, MD, PhD 0034 981 552 200 alvaro.hermida.ameijeiras@sergas.es Less << |
NCT03190694 | Chronic Kidney Diseases ... More >> Proteinuria Less << | Phase 2 | Recruiting | December 1, 2019 | Canada, British Columbia ... More >> Nephrology Dept., Vancouver Coastal Health Research Institute Recruiting Vancouver, British Columbia, Canada, V5Z 1M9 Contact: Sean Barbour, MD +1-604-875-5950 Sean.Barbour@vch.ca Canada, Ontario Division of Nephrology University Health Network, University of Toronto Recruiting Toronto, Ontario, Canada, M5G 2C4 Contact: David Cherney, Prof.MD +1-416-340-4151 david.cherney@uhn.ca Malaysia Nephrology Unit, University Kebangsaan Malaysia Recruiting Kuala Lumpur, Malaysia, 5600 Contact: Halim Gafor, Prof.MD halimgafor@gmail.com University Malaya Medical Centre, Ward 8TE Recruiting Kuala Lumpur, Malaysia, 59100 Contact: Lim Soo Kun, Prof.MD 603-79494422 sookun_73@yahoo.com Netherlands Dept Internal Medicine, division of Nephrology Hospital Group Twente Not yet recruiting Almelo, Netherlands, 7609 PP Contact: Gozewijn D Laverman, MD +31-887084350 g.laverman@zgt.nl Dept.of Nephrology, VU University Medical Center Recruiting Amsterdam, Netherlands, 1081 HV Contact: Marcus G Vervloet, MD +31-9032129301 m.vervloet@vumc.nl Dept. Nephrology, University Medical Center Groningen Recruiting Groningen, Netherlands, 9713 GZ Contact: Ron T Gansevoort, MD +31-50-3616161 R.T.Gansevoort@umcg.nl Less << |
NCT02777073 | Type 1 Diabetes | Phase 3 | Completed | - | United States, New York ... More >> ECMC Ambulatory Center, 3rd Floor Buffalo, New York, United States, 14215 Less << |
NCT03030235 | Chronic Heart Failure With Pre... More >>served Systolic Function Less << | Phase 4 | Recruiting | September 2019 | - |
NCT03338855 | Diabetes Mellitus, Type 2|Skel... More >>etal Muscle Insulin Sensitivity Less << | PHASE4 | COMPLETED | 2019-11-04 | Research Site, Maastricht, 622... More >>9 ER, Netherlands Less << |
NCT03619213 | Heart Failure With Preserved E... More >>jection Fraction Less << | Phase 3 | Recruiting | June 22, 2021 | - |
NCT03537131 | Diabetes Mellitus, Type 1 | Phase 2 | Recruiting | December 22, 2018 | United Kingdom ... More >> Clinical Research Unit, OCDEM, Churchill Hospital Recruiting Oxford, Oxfordshire, United Kingdom, OX3 7LE Contact: Lia Anguelova, MD lia.anguelova@ocdem.ox.ac.uk Principal Investigator: Ioannis I Spiliotis, MD Less << |
NCT02528019 | Effects of the DPP-4 Inhibitor... More >>s or SGLT2 Inhibitors on the Protective Actions for Diabetic Complications Less << | Phase 4 | Unknown | August 2018 | Japan ... More >> Kurume University Hospital Recruiting Kurume city, Japan, 830-0011 Contact: Nobuhiro Tahara, MD, PhD +81-942-31-7580 ntahara@med.kurume-u.ac.jp Contact: Sho-ichi Yamagishi, MD, PhD +81-942-31-7562 Principal Investigator: Nobuhiro Tahara, MD, PhD Less << |
NCT02857764 | - | Completed | - | - | |
NCT03249506 | - | Completed | - | United States, Pennsylvania ... More >> Health ResearchTx, LLC Trevose, Pennsylvania, United States, 19053 Less << | |
NCT03492580 | - | Completed | - | United States, New Jersey ... More >> Janssen Investigative Site Titusville, New Jersey, United States, 08560 Less << | |
NCT02597049 | Type 2 Diabetes Mellitus | Phase 3 | Completed | - | - |
NCT02597049 | - | Completed | - | - | |
NCT02636192 | - | Completed | - | - | |
NCT03601910 | Type II Diabetes Mellitus | Phase 1 | Active, not recruiting | November 9, 2018 | Korea, Republic of ... More >> The Catholic University of Korea, Seoul ST. Mary's Hospital Seoul, Korea, Republic of Less << |
NCT02561130 | Type 2 Diabetes Mellitus | Phase 4 | Active, not recruiting | October 2018 | Canada, Alberta ... More >> University of Calgary Calgary, Alberta, Canada, T2T 5C7 Canada, Manitoba Health Science Centre Winnipeg, Manitoba, Canada, R3E 3P4 Canada, Ontario McMaster University Hamilton, Ontario, Canada, L8N 3Z5 St. Joseph's Hospital London, Ontario, Canada, N6A 4V2 Western University London, Ontario, Canada, N6G 2M1 LMC Toronto, Ontario, Canada, M4G 3E8 St. Michaels's Hospital Toronto, Ontario, Canada, M5C 2T2 Less << |
NCT02696941 | Non-alcoholic Fatty Liver Dise... More >>ase Less << | Phase 1 | Completed | - | United Kingdom ... More >> University of Oxford Oxford, United Kingdom Less << |
NCT03364985 | Healthy | Phase 1 | Recruiting | December 2018 | Korea, Republic of ... More >> Seoul National University Hospital Recruiting Seoul, Korea, Republic of Contact: Kyung-Sang Yu, MD, PhD 82-2-2072-1920 ksyu@snu.ac.kr Less << |
NCT02879409 | Diabetes Mellitus Type 2 | Not Applicable | Recruiting | August 2019 | Qatar ... More >> Hamad Medical Corporation Recruiting Doha, Qatar, 3050 Contact: Ibrahim Janahi, MD 4439-2434 ext 00974 Imohd@hamad.qa Principal Investigator: Ibrahim Janahi, MD Sub-Investigator: Mashhood Siddique, MD Sub-Investigator: Hamda Ali, MD Less << |
NCT03209089 | - | Active, not recruiting | December 16, 2018 | Russian Federation ... More >> Research Site Belgorod Region, Shebekino, Russian Federation, D1690R00037 Research Site Belgorod Region, Volokonovsky R-n, P. Volokonovka, Russian Federation, D1690R00037 Research Site Gis-Khrustalny, Russian Federation, D1690R00037 Research Site Izhevsk, Russian Federation, D1690R00037 Research Site Kazan, Russian Federation, D1690R00037 Research Site Lipetsk, Russian Federation, D1690R00037 Research Site N. Novgorod Region, Russian Federation, D1690R00037 Research Site N. Novgorod, Russian Federation, D1690R00037 Research Site Novomoskovsk, Russian Federation, D1690R00037 Research Site Novosibirsk, Russian Federation, D1690R00037 Research Site Perm, Russian Federation, D1690R00037 Research Site Ryazan, Russian Federation, D1690R00037 Research Site Samara, Russian Federation, D1690R00037 Research Site St-petersburg, Russian Federation, D1690R00037 Research Site Tambov Region, Russian Federation, D1690R00037 Research Site Volzhsk, Russian Federation, D1690R00037 Research Site Voronezh Region, Novovoronezh, Russian Federation, D1690R00037 Research Site Voronezh, Russian Federation, D1690R00037 Research Site Yaroslavl, Russian Federation, D1690R00037 Research Site Yoshkar-Ola, Russian Federation, D1690R00037 Less << | |
NCT03646799 | Type II Diabetes | Phase 1 | Recruiting | September 14, 2018 | Korea, Republic of ... More >> Yonsei University Severance Hospital Recruiting Soeul, Korea, Republic of Contact: Min Soo Park, Ph.D. M.D +82 2 2228 0400 minspark@yuhs.ac Principal Investigator: Min Soo Park, Ph.D. M.D Less << |
NCT03627039 | - | Not yet recruiting | August 1, 2020 | - | |
NCT03038789 | - | Recruiting | January 31, 2020 | Korea, Republic of ... More >> Research Site Recruiting Busan, Korea, Republic of Research Site Recruiting ChungCheong, Korea, Republic of Research Site Recruiting DaeGu, Korea, Republic of Research Site Recruiting DaeJeon, Korea, Republic of Research Site Recruiting GyeongGi, Korea, Republic of Research Site Active, not recruiting GyeongGi, Korea, Republic of Research Site Recruiting Seoul, Korea, Republic of Research Site Withdrawn Seoul, Korea, Republic of Research Site Recruiting WonJu, Korea, Republic of Less << | |
NCT02969798 | Diabetes Mellitus, Type 2 ... More >> Impaired Glucose Tolerance (IGT) Impaired Fasting Glucose (IFG) Less << | Not Applicable | Recruiting | July 2020 | United States, Texas ... More >> The University of Texas Health Science Center at San Antonio Recruiting San Antonio, Texas, United States, 78229 Contact: Ralph A DeFronzo, MD 210-567-6691 defronzo@uthscsa.edu Contact: Monica Palomo, BS 210-567-6710 palomom@uthscsa.edu Principal Investigator: Ralph A DeFronzo, MD Sub-Investigator: Eugenio Cersosimo, MD Less << |
NCT02252224 | - | Completed | - | Korea, Republic of ... More >> Research Site Bucheon-si, Korea, Republic of Research Site Busan, Korea, Republic of Research Site Daejeon, Korea, Republic of Research Site Jeonju-si, Korea, Republic of Research Site Seoul, Korea, Republic of Research Site Wonju-si, Korea, Republic of Less << | |
NCT02695173 | - | Recruiting | November 30, 2019 | United States, Delaware ... More >> Research Site Recruiting Wilmington, Delaware, United States United States, District of Columbia Research Site Recruiting Washington, District of Columbia, United States United Kingdom Research Site Recruiting London, United Kingdom Less << | |
NCT02695082 | - | Recruiting | November 30, 2019 | United States, Delaware ... More >> Research Site Recruiting Wilmington, Delaware, United States United States, District of Columbia Research Site Recruiting Washington, District of Columbia, United States United Kingdom Research Site Recruiting London, United Kingdom Less << | |
NCT03422263 | - | Recruiting | December 31, 2019 | Switzerland ... More >> Berner Klinik Montana Recruiting Crans-Montana, Valais, Switzerland, 3963 Contact: Devine S Frundi, MD +41 274855242 devine.frundi@bernerklinik.ch Less << | |
NCT05957887 | STEMI | PHASE3 | RECRUITING | 2025-04-15 | Helwan University, Cairo, Egyp... More >>t Less << |
NCT06326034 | Diabetic Nephropathy Type 2 | PHASE4 | COMPLETED | 2023-01-01 | Mohammed Mahmood Mahmood, Bagh... More >>dad, 00964, Iraq Less << |
NCT04534270 | Proteinuria | PHASE4 | COMPLETED | 2022-03-30 | Children's Hospital of Fudan U... More >>niversity, Shanghai, Shanghai, 201102, China Less << |
NCT04200586 | Type2 Diabetes|Heart Failure W... More >>ith Reduced Ejection Fraction Less << | PHASE4 | UNKNOWN | 2021-09-30 | Queen Mary Hospital, Hong Kong... More >>, Hong Kong Less << |
NCT05713851 | AKI - Acute Kidney Injury|Biom... More >>arkers|Transition to CKD|CKD Less << | PHASE2|PHASE3 | RECRUITING | 2025-01-01 | Instituto Nacional de Ciencias... More >> Médicas y Nutrición Salvador Zubirán, Mexico City, 14080, Mexico Less << |
NCT05420285 | Heart Failure|Reduced Ejection... More >> Fraction Less << | PHASE2 | UNKNOWN | 2025-05-24 | Pitié-Salpêtrière Hospital, Pa... More >>ris, 75013, France Less << |
NCT05759000 | Heart Failure | RECRUITING | 2025-12-09 | The Chinese University of Hong... More >> Kong, Shatin, 999077, Hong Kong Less << | |
NCT04707352 | Heart Failure | PHASE3 | COMPLETED | 2023-03-26 | Hospital Clinico Universitario... More >> Virgen de la Arrixaca, Murcia, 30003, Spain Less << |
NCT06420167 | Renal AL Amyloidosis | PHASE2 | RECRUITING | 2025-04-27 | Karmanos Cancer Institute, Det... More >>roit, Michigan, 48201, United States Less << |
NCT04818034 | Cystinuria | PHASE2 | RECRUITING | 2026-06-01 | University of California, San ... More >>Francisco, San Francisco, California, 94143, United States Less << |
NCT06111768 | Cardiorenal Syndrome | PHASE2 | RECRUITING | 2025-05-26 | Yale New Haven Hospital, New H... More >>aven, Connecticut, 06520, United States Less << |
NCT05685394 | End-stage Kidney Disease | PHASE4 | RECRUITING | 2024-12-01 | Centro de Pesquisas Clínicas, ... More >>Campinas, SP, 13083610, Brazil Less << |
NCT05196347 | Chronic Kidney Diseases | PHASE3 | UNKNOWN | 2023-09-30 | - |
NCT00554450 | Diabetes Mellitus, Type 2 | PHASE1 | COMPLETED | 2025-10-08 | Advanced Clinical Research Ins... More >>titute, Anaheim, California, 92801, United States|Elite Research Institute, Miami, Florida, 33169, United States|Prism Research, St. Paul, Minnesota, 55114, United States|Dgd Research, Inc., San Antonio, Texas, 78229, United States Less << |
NCT05618223 | Rheumatic Heart Disease|Heart ... More >>Failure|Mitral Stenosis Less << | PHASE3 | UNKNOWN | 2023-06-30 | Sebelas Maret University Hospi... More >>tal, Sukoharjo, Central Java, 58192, Indonesia Less << |
NCT06383832 | Overweight|Carbohydrate|Sodium... More >>-glucose Transporter 2 Inhibitors Less << | PHASE4 | COMPLETED | 2023-12-26 | Zhujiang Hospital of Southern ... More >>Medical University, Guangzhou, Guangdong, China|Zhujiang Hospital, Guangzhou, Guangdong, China Less << |
NCT01294436 | Type2 Diabetes|High Blood Suga... More >>r Less << | PHASE3 | COMPLETED | 2025-09-12 | Research Site, Nagoya, Aichi, ... More >>Japan|Research Site, Owariasahi, Aichi, Japan|Research Site, Toyohashi, Aichi, Japan|Research Site, Hirosaki, Aomori, Japan|Research Site, Niihama, Ehime, Japan|Research Site, Itoshima, Fukuoka, Japan|Research Site, Yukuhashi, Fukuoka, Japan|Research Site, Annaka, Gunma, Japan|Research Site, OTA, Gunma, Japan|Research Site, Aki-gun, Hiroshima, Japan|Research Site, Sapporo, Hokkaido, Japan|Research Site, Sanuki, Kagawa, Japan|Research Site, Takamatsu, Kagawa, Japan|Research Site, Kamakura, Kanagawa, Japan|Research Site, Kawasaki, Kanagawa, Japan|Research Site, Yokohamashi, Kanagawa, Japan|Research Site, Yokohama, Kanagawa, Japan|Research Site, Zushi, Kanagawa, Japan|Research Site, Sendai, Miyagi, Japan|Research Site, Matsumoto, Nagano, Japan|Research Site, Suita, Osaka, Japan|Research Site, Otsu, Shiga, Japan|Research Site, Atami, Shizuoka, Japan|Research Site, Komatsushima, Tokushima, Japan|Research Site, Chiyoda, Tokyo, Japan|Research Site, Chuo, Tokyo, Japan|Research Site, Mitaka, Tokyo, Japan|Research Site, OTA, Tokyo, Japan|Research Site, Shibuya, Tokyo, Japan|Research Site, Shinjuku, Tokyo, Japan|Research Site, Taito, Tokyo, Japan|Research Site, Takaoka, Toyama, Japan|Research Site, UBE, Yamaguchi, Japan|Research Site, Fukuoka, Japan|Research Site, Hiroshima, Japan|Research Site, Kochi, Japan|Research Site, Osaka, Japan|Research Site, Shizuoka, Japan|Research Site, Toyama, Japan Less << |
NCT04887935 | Prostate Cancer|Cancer of Pros... More >>tate Less << | PHASE1 | RECRUITING | 2026-08-31 | Washington University School o... More >>f Medicine, Saint Louis, Missouri, 63110, United States Less << |
NCT04634500 | T2DM (Type 2 Diabetes Mellitus... More >>) Less << | PHASE3 | COMPLETED | 2021-11-03 | Daewoong pharmatceutical, Soeu... More >>l, Korea, Republic of Less << |
NCT06398977 | Peritoneal Dialysis Complicati... More >>on|Renal Function Aggravated|Sodium-glucose Co-transporter-2 Inhibitors Less << | RECRUITING | 2026-12-31 | Sichuan Academy of Medical Sci... More >>ences and Sichuan Provincial People's Hospita, Chengdu, Sichuan, 610000, China Less << | |
NCT00726505 | Diabetes, NOS | PHASE1 | TERMINATED | 2025-08-09 | University Of Texas Health Cen... More >>ter At San Antonio, San Antonio, Texas, 78229, United States Less << |
NCT06572215 | Chronic Kidney Diseases | RECRUITING | 2025-01-01 | King's College Hospital, Londo... More >>n, United Kingdom Less << | |
NCT05250011 | Heart Failure, Reduced Ejectio... More >>n Fraction Less << | COMPLETED | 2024-04-15 | Research Site, Brescia, BS, 25... More >>123, Italy|Research Site, Catanzaro, CZ, 88100, Italy|Research Site, Foggia, FG, 71122, Italy|Research Site, Firenze, FI, 50100, Italy|Research Site, Genova, GE, 16132, Italy|Research Site, Monza, MB, 20900, Italy|Research Site, Milano, MI, 20122, Italy|Research Site, Roma, RM, 00163, Italy|Research Site, Roma, RM, 00189, Italy|Research Site, Trieste, TS, 34125, Italy|Research Site, Napoli, 80131, Italy Less << | |
NCT06610526 | Chronic Kidney Disease | PHASE4 | RECRUITING | 2027-06-21 | Research Site, Beijing, 100034... More >>, China|Research Site, Beijing, 100044, China|Research Site, Beijing, 100068, China|Research Site, Beijing, 100191, China|Research Site, Beijing, 102206, China|Research Site, Changchun, 130021, China|Research Site, Changsha, 410011, China|Research Site, Dongguan, 523059, China|Research Site, Foshan, 528308, China|Research Site, Fuyang, 236012, China|Research Site, Fuzhou, 350001, China|Research Site, Ganzhou, 341099, China|Research Site, Harbin, 150000, China|Research Site, Hefei, 230601, China|Research Site, Hengyang, 421001, China|Research Site, Huaian, 223399, China|Research Site, Huizhou, 516001, China|Research Site, Jilin, 132011, China|Research Site, Jinan, 250014, China|Research Site, Lanzhou, 730000, China|Research Site, Nanchang, 330006, China|Research Site, Nanjing, 210029, China|Research Site, Nanning, 530021, China|Research Site, Ningbo, 315010, China|Research Site, Shanghai, 200090, China|Research Site, Shenzhen, 518036, China|Research Site, Suzhou, 215004, China|Research Site, Taian, 271099, China|Research Site, Tianjin, 300121, China|Research Site, Wuhu, 241000, China|Research Site, Wuxi, 214023, China|Research Site, Xiamen, 361004, China|Research Site, Xian, 710000, China Less << |
NCT05621551 | Diabetes Mellitus, Type 2|Card... More >>iac Surgery Less << | PHASE4 | UNKNOWN | 2023-07-01 | National Clinical Research Cen... More >>ter for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Beijing, 100037, China Less << |
NCT00908271 | Type 2 Diabetes Mellitus | PHASE1 | COMPLETED | 2025-08-09 | Covance Clinical Research Unit... More >>, Inc., Madison, Wisconsin, 53704, United States Less << |
NCT05058859 | Cystinuria | PHASE2 | NOT_YET_RECRUITING | 2026-12-01 | University of California, San ... More >>Francisco, San Francisco, California, 94143, United States Less << |
NCT06365541 | The Efficacy and Safety of Dap... More >>agliflozin in Improving Heart Failure in Dialysis Patients Less << | PHASE4 | RECRUITING | 2024-08-31 | The People's Hospital of Gaozh... More >>ou, Maoming, Guangdong, 525200, China Less << |
NCT06578520 | Heart Failure | PHASE4 | RECRUITING | 2025-12-31 | Hospital Clínico Universitario... More >> de Valencia, Valencia, 46010, Spain Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.45mL 0.49mL 0.24mL |
12.23mL 2.45mL 1.22mL |
24.46mL 4.89mL 2.45mL |
|
Dissolving Methods |
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:
in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
|