Structure of Dinaciclib
CAS No.: 779353-01-4
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Dinaciclib is a potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively.
Synonyms: SCH 727965; PS-095760
4.5
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
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CAS No. : | 779353-01-4 |
Formula : | C21H28N6O2 |
M.W : | 396.49 |
SMILES Code : | OCC[C@H]1N(CCCC1)C2=NC3=C(C=NN3C(NCC4=C[N+]([O-])=CC=C4)=C2)CC |
Synonyms : |
SCH 727965; PS-095760
|
MDL No. : | MFCD16037702 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302 |
Precautionary Statements: | P280-P305+P351+P338 |
Target |
|
In Vitro:
Cell Line
|
Concentration | Treated Time | Description | References |
MCF7-Re cells | 0.5 μM | 48 h | Dinaciclib significantly reduced BRCA1 phosphorylation and expression, induced more DNA damage and apoptosis, and significantly increased the sensitivity to cisplatin in MCF7-Re cells. | PMC5913295 |
BCSphCs | 10 nM | 6 days | To evaluate the effect of Dinaciclib on the cell viability of BCSphCs, results showed that Dinaciclib significantly reduced the cell viability of BCSphCs | PMC8993694 |
CLB-GA cells | 10 nM | 8 h | To investigate the effect of Dinaciclib on TERT mRNA expression and chromatin occupancy of epigenetic modulators at the TERT gene locus, results showed that Dinaciclib significantly inhibited TERT expression and reduced the binding of Brd4 and H3K27Ac at the TERT promoter or gene body. | PMC7056551 |
Kelly cells | 10 nM | 8 h | To investigate the effect of Dinaciclib on TERT mRNA expression, results showed that Dinaciclib significantly inhibited TERT expression. | PMC7056551 |
HB PDX cells | 0.1 µM | 24 h | Dinaciclib significantly inhibited the proliferation of PDX282 and PDX303 cells and induced apoptosis, while having less effect on PDX214 cells with low CDK9 expression. | PMC11185924 |
THP-1 cells | 10 nM | 21 days | Screening for CDK9 inhibitor-resistant cells | PMC8567840 |
HCC PDXOs | 1 μM | 48 h | To evaluate the cytotoxic effects of Dinaciclib on HCC PDXOs, results showed that Dinaciclib significantly reduced cell viability. | PMC9377092 |
THLE-2 | 1 μM | 48 h | To evaluate the toxicity of Dinaciclib on non-tumorigenic liver epithelial cells THLE-2, results showed that Dinaciclib had lower toxicity on THLE-2 cells. | PMC9377092 |
In Vivo:
Species
|
Animal Model
|
Administration | Dosage | Frequency | Description | References |
Mice | BCSphCs xenograft model | Intraperitoneal injection | 25 mg/kg | 3 times per week for 3 weeks | To evaluate the effect of Dinaciclib on tumor growth in the BCSphCs xenograft model, results showed that Dinaciclib significantly reduced tumor volume | PMC8993694 |
nude mice | CLB-GA xenograft model | intraperitoneal injection | 40 mg/kg | daily, continuous treatment | To investigate the effect of Dinaciclib on the growth of CLB-GA xenograft tumors, results showed that Dinaciclib significantly inhibited tumor growth, and the effect was enhanced when combined with AZD5153. | PMC7056551 |
mice | KrasG12DSetd2–/– lung tumor model | intraperitoneal injection | 20 mg/kg | 3 times weekly for 7 weeks | dinaciclib markedly suppressed the growth of KrasG12DSetd2–/– lung tumors and significantly prolonged the survival of mice | PMC9977508 |
Nude mice | HB PDX model | Intraperitoneal injection | 20 mg/kg | 3 times per week for 11 days | Dinaciclib significantly reduced the volume of PDX282 tumors but also caused some side effects such as weight loss and unexpected death. | PMC11185924 |
Mice | HCC PDX model | Intraperitoneal injection | 5 mg/kg | Three times a week until tumors reached endpoint volume | To evaluate the tumor suppressive effects of Dinaciclib in combination with Ixazomib on HCC PDX tumors, results showed that the combination treatment significantly inhibited tumor growth and outperformed Sorafenib alone. | PMC9377092 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT00937937 | Acral Lentiginous Melanoma|Cut... More >>aneous Nodular Melanoma|Lentigo Maligna Melanoma|Low-CSD Melanoma|Mucosal Melanoma|Recurrent Melanoma|Stage IV Cutaneous Melanoma AJCC v6 and v7 Less << | PHASE2 | ACTIVE_NOT_RECRUITING | 2025-03-08 | Providence Hospital, Mobile, A... More >>labama, 36608, United States|Mercy Hospital Fort Smith, Fort Smith, Arkansas, 72903, United States|University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, United States|Highlands Oncology Group - Rogers, Rogers, Arkansas, 72758, United States|East Bay Radiation Oncology Center, Castro Valley, California, 94546, United States|Eden Hospital Medical Center, Castro Valley, California, 94546, United States|Valley Medical Oncology Consultants-Castro Valley, Castro Valley, California, 94546, United States|Bay Area Breast Surgeons Inc, Emeryville, California, 94608, United States|Valley Medical Oncology Consultants-Fremont, Fremont, California, 94538, United States|Contra Costa Regional Medical Center, Martinez, California, 94553-3156, United States|El Camino Hospital, Mountain View, California, 94040, United States|Highland General Hospital, Oakland, California, 94602, United States|Alta Bates Summit Medical Center - Summit Campus, Oakland, California, 94609, United States|Bay Area Tumor Institute, Oakland, California, 94609, United States|Hematology and Oncology Associates-Oakland, Oakland, California, 94609, United States|Tom K Lee Inc, Oakland, California, 94609, United States|UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California, 92868, United States|Valley Care Health System - Pleasanton, Pleasanton, California, 94588, United States|Valley Medical Oncology Consultants, Pleasanton, California, 94588, United States|Doctors Medical Center- JC Robinson Regional Cancer Center, San Pablo, California, 94806, United States|Poudre Valley Hospital, Fort Collins, Colorado, 80524, United States|Smilow Cancer Hospital Care Center at Saint Francis, Hartford, Connecticut, 06105, United States|Boca Raton Comprehensive Cancer Center, Boca Raton, Florida, 33486, United States|Orlando Health Cancer Institute, Orlando, Florida, 32806, United States|Memorial Health University Medical Center, Savannah, Georgia, 31404, United States|Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah, Georgia, 31405, United States|South Georgia Medical Center/Pearlman Cancer Center, Valdosta, Georgia, 31602, United States|OSF Saint Anthony's Health Center, Alton, Illinois, 62002, United States|Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois, 62526, United States|Decatur Memorial Hospital, Decatur, Illinois, 62526, United States|Advocate Good Samaritan Hospital, Downers Grove, Illinois, 60515, United States|Loyola University Medical Center, Maywood, Illinois, 60153, United States|SSM Health Good Samaritan, Mount Vernon, Illinois, 62864, United States|Springfield Memorial Hospital, Springfield, Illinois, 62781, United States|Franciscan Saint Francis Health-Beech Grove, Beech Grove, Indiana, 46107, United States|Reid Health, Richmond, Indiana, 47374, United States|Cancer Center of Kansas - Chanute, Chanute, Kansas, 66720, United States|Cancer Center of Kansas - Dodge City, Dodge City, Kansas, 67801, United States|Cancer Center of Kansas - El Dorado, El Dorado, Kansas, 67042, United States|Cancer Center of Kansas - Fort Scott, Fort Scott, Kansas, 66701, United States|HaysMed, Hays, Kansas, 67601, United States|Hutchinson Regional Medical Center, Hutchinson, Kansas, 67502, United States|Cancer Center of Kansas-Independence, Independence, Kansas, 67301, United States|University of Kansas Cancer Center, Kansas City, Kansas, 66160, United States|Cancer Center of Kansas-Kingman, Kingman, Kansas, 67068, United States|Lawrence Memorial Hospital, Lawrence, Kansas, 66044, United States|Southwest Medical Center, Liberal, Kansas, 67901, United States|Cancer Center of Kansas-Liberal, Liberal, Kansas, 67905, United States|Cancer Center of Kansas - Newton, Newton, Kansas, 67114, United States|Olathe Cancer Center, Olathe, Kansas, 66061, United States|Menorah Medical Center, Overland Park, Kansas, 66209, United States|Saint Luke's South Hospital, Overland Park, Kansas, 66213, United States|Cancer Center of Kansas - Parsons, Parsons, Kansas, 67357, United States|Ascension Via Christi - Pittsburg, Pittsburg, Kansas, 66762, United States|Kansas City NCI Community Oncology Research Program, Prairie Village, Kansas, 66208, United States|Cancer Center of Kansas - Pratt, Pratt, Kansas, 67124, United States|Cancer Center of Kansas - Salina, Salina, Kansas, 67401, United States|Salina Regional Health Center, Salina, Kansas, 67401, United States|Advent Health - Shawnee Mission Medical Center, Shawnee Mission, Kansas, 66204, United States|Cotton O'Neil Cancer Center / Stormont Vail Health, Topeka, Kansas, 66606, United States|University of Kansas Health System Saint Francis Campus, Topeka, Kansas, 66606, United States|Cancer Center of Kansas - Wellington, Wellington, Kansas, 67152, United States|Associates In Womens Health, Wichita, Kansas, 67208, United States|Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita, Kansas, 67208, United States|Ascension Via Christi Hospitals Wichita, Wichita, Kansas, 67214, United States|Cancer Center of Kansas - Wichita, Wichita, Kansas, 67214, United States|Wichita NCI Community Oncology Research Program, Wichita, Kansas, 67214, United States|Cancer Center of Kansas - Winfield, Winfield, Kansas, 67156, United States|Baton Rouge General Medical Center, Baton Rouge, Louisiana, 70806, United States|Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana, 70809, United States|Louisiana State University Health Science Center, New Orleans, Louisiana, 70112, United States|University Medical Center New Orleans, New Orleans, Louisiana, 70112, United States|Boston Medical Center, Boston, Massachusetts, 02118, United States|Michigan Cancer Research Consortium NCORP, Ann Arbor, Michigan, 48106, United States|Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan, 48106, United States|University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, 48109, United States|Bronson Battle Creek, Battle Creek, Michigan, 49017, United States|Spectrum Health Big Rapids Hospital, Big Rapids, Michigan, 49307, United States|Corewell Health Dearborn Hospital, Dearborn, Michigan, 48124, United States|Wayne State University/Karmanos Cancer Institute, Detroit, Michigan, 48201, United States|Henry Ford Health Saint John Hospital, Detroit, Michigan, 48236, United States|Hurley Medical Center, Flint, Michigan, 48503, United States|Genesys Regional Medical Center-West Flint Campus, Flint, Michigan, 48532, United States|Cancer Research Consortium of West Michigan NCORP, Grand Rapids, Michigan, 49503, United States|Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan, 49503, United States|Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan, 49503, United States|Allegiance Health, Jackson, Michigan, 49201, United States|University of Michigan Health - Sparrow Lansing, Lansing, Michigan, 48912, United States|Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan, 48154, United States|Trinity Health Muskegon Hospital, Muskegon, Michigan, 49444, United States|Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac, Michigan, 48341, United States|Lake Huron Medical Center, Port Huron, Michigan, 48060, United States|MyMichigan Medical Center Saginaw, Saginaw, Michigan, 48601, United States|Munson Medical Center, Traverse City, Michigan, 49684, United States|Henry Ford Health Warren Hospital, Warren, Michigan, 48093, United States|University of Michigan Health - West, Wyoming, Michigan, 49519, United States|Saint Francis Medical Center, Cape Girardeau, Missouri, 63703, United States|University Health Truman Medical Center, Kansas City, Missouri, 64108, United States|Saint Luke's Hospital of Kansas City, Kansas City, Missouri, 64111, United States|Saint Joseph Health Center, Kansas City, Missouri, 64114, United States|North Kansas City Hospital, Kansas City, Missouri, 64116, United States|Heartland Hematology and Oncology Associates Incorporated, Kansas City, Missouri, 64118, United States|Research Medical Center, Kansas City, Missouri, 64132, United States|Saint Luke's East - Lee's Summit, Lee's Summit, Missouri, 64086, United States|Liberty Radiation Oncology Center, Liberty, Missouri, 64068, United States|Heartland Regional Medical Center, Saint Joseph, Missouri, 64506, United States|Saint Louis Cancer and Breast Institute-South City, Saint Louis, Missouri, 63109, United States|Mercy Hospital Saint Louis, Saint Louis, Missouri, 63141, United States|Saint Louis-Cape Girardeau CCOP, Saint Louis, Missouri, 63141, United States|Billings Clinic Cancer Center, Billings, Montana, 59101, United States|Northern Rockies Radiation Oncology Center, Billings, Montana, 59101, United States|Saint Vincent Healthcare, Billings, Montana, 59101, United States|Montana Cancer Consortium NCORP, Billings, Montana, 59102, United States|Saint Vincent Frontier Cancer Center, Billings, Montana, 59102, United States|Bozeman Health Deaconess Hospital, Bozeman, Montana, 59715, United States|Saint James Community Hospital and Cancer Treatment Center, Butte, Montana, 59701, United States|Benefis Sletten Cancer Institute, Great Falls, Montana, 59405, United States|Berdeaux, Donald MD (UIA Investigator), Great Falls, Montana, 59405, United States|Great Falls Clinic, Great Falls, Montana, 59405, United States|Northern Montana Hospital, Havre, Montana, 59501, United States|Saint Peter's Community Hospital, Helena, Montana, 59601, United States|Glacier Oncology PLLC, Kalispell, Montana, 59901, United States|Kalispell Medical Oncology, Kalispell, Montana, 59901, United States|Logan Health Medical Center, Kalispell, Montana, 59901, United States|Montana Cancer Specialists, Missoula, Montana, 59802, United States|Saint Patrick Hospital - Community Hospital, Missoula, Montana, 59802, United States|Community Medical Center, Missoula, Montana, 59804, United States|Guardian Oncology and Center for Wellness, Missoula, Montana, 59804, United States|University Medical Center of Southern Nevada, Las Vegas, Nevada, 89102, United States|Nevada Cancer Institute-Summerlin Campus, Las Vegas, Nevada, 89135, United States|University of Rochester, Rochester, New York, 14642, United States|Novant Health Presbyterian Medical Center, Charlotte, North Carolina, 28204, United States|Wayne Memorial Hospital, Goldsboro, North Carolina, 27534, United States|FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst, North Carolina, 28374, United States|Southeast Clinical Oncology Research Consortium NCORP, Winston-Salem, North Carolina, 27104, United States|Grandview Hospital, Dayton, Ohio, 45405, United States|Good Samaritan Hospital - Dayton, Dayton, Ohio, 45406, United States|Miami Valley Hospital, Dayton, Ohio, 45409, United States|Miami Valley Hospital North, Dayton, Ohio, 45415, United States|Dayton NCI Community Oncology Research Program, Dayton, Ohio, 45459, United States|Blanchard Valley Hospital, Findlay, Ohio, 45840, United States|Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio, 45005-1066, United States|Wayne Hospital, Greenville, Ohio, 45331, United States|Kettering Medical Center, Kettering, Ohio, 45429, United States|Upper Valley Medical Center, Troy, Ohio, 45373, United States|Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center, Wilmington, Ohio, 45177, United States|Greene Memorial Hospital, Xenia, Ohio, 45385, United States|Saint Charles Health System, Bend, Oregon, 97701, United States|Providence Milwaukie Hospital, Milwaukie, Oregon, 97222, United States|Providence Portland Medical Center, Portland, Oregon, 97213, United States|Adventist Medical Center, Portland, Oregon, 97216, United States|Providence Saint Vincent Medical Center, Portland, Oregon, 97225, United States|Salem Hospital, Salem, Oregon, 97301, United States|Prisma Health Cancer Institute - Spartanburg, Boiling Springs, South Carolina, 29316, United States|Prisma Health Cancer Institute - Easley, Easley, South Carolina, 29640, United States|McLeod Regional Medical Center, Florence, South Carolina, 29506, United States|Greenville Health System Cancer Institute-Andrews, Greenville, South Carolina, 29601, United States|Saint Francis Hospital, Greenville, South Carolina, 29601, United States|Prisma Health Cancer Institute - Butternut, Greenville, South Carolina, 29605, United States|Prisma Health Cancer Institute - Faris, Greenville, South Carolina, 29605, United States|Prisma Health Greenville Memorial Hospital, Greenville, South Carolina, 29605, United States|Prisma Health Cancer Institute - Eastside, Greenville, South Carolina, 29615, United States|Self Regional Healthcare, Greenwood, South Carolina, 29646, United States|Prisma Health Cancer Institute - Greer, Greer, South Carolina, 29650, United States|Prisma Health Cancer Institute - Seneca, Seneca, South Carolina, 29672, United States|Wellmont Holston Valley Hospital and Medical Center, Kingsport, Tennessee, 37660, United States|Thompson Cancer Survival Center, Knoxville, Tennessee, 37916, United States|Medical City Dallas Hospital, Dallas, Texas, 75230, United States|Scott and White Memorial Hospital, Temple, Texas, 76508, United States|Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah, 84112, United States|Danville Regional Medical Center, Danville, Virginia, 24541, United States|Sovah Health Martinsville, Martinsville, Virginia, 24112, United States|Ballad Health Cancer Care - Norton, Norton, Virginia, 24273, United States|PeaceHealth Saint Joseph Medical Center, Bellingham, Washington, 98225, United States|Kadlec Clinic Hematology and Oncology, Kennewick, Washington, 99336, United States|Skagit Valley Hospital, Mount Vernon, Washington, 98274, United States|Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo, Washington, 98370, United States|Harborview Medical Center, Seattle, Washington, 98104, United States|Minor and James Medical PLLC, Seattle, Washington, 98104, United States|Fred Hutchinson Cancer Center, Seattle, Washington, 98109, United States|Kaiser Permanente Washington, Seattle, Washington, 98112, United States|Swedish Medical Center-First Hill, Seattle, Washington, 98122, United States|University of Washington Medical Center - Montlake, Seattle, Washington, 98195, United States|Saint Michael Cancer Center, Silverdale, Washington, 98383, United States|Cancer Care Northwest - Spokane South, Spokane, Washington, 99202, United States|Evergreen Hematology and Oncology PS, Spokane, Washington, 99218, United States|PeaceHealth Southwest Medical Center, Vancouver, Washington, 98664, United States|Wenatchee Valley Hospital and Clinics, Wenatchee, Washington, 98801, United States|Rocky Mountain Oncology, Casper, Wyoming, 82609, United States|Welch Cancer Center, Sheridan, Wyoming, 82801, United States Less << |
NCT00871663 | Solid Tumors|Lymphoma, Non-Hod... More >>gkin|Multiple Myeloma|Leukemia, Lymphocytic, Chronic. B-Cell Less << | PHASE1 | COMPLETED | 2025-10-12 | - |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.52mL 0.50mL 0.25mL |
12.61mL 2.52mL 1.26mL |
25.22mL 5.04mL 2.52mL |
Tags: Dinaciclib | SCH 727965 | SCH727965 | SCH-727965 | CDK | Apoptosis | Cyclin dependent kinase | cell cycle arrest | CDK inhibitor | transcriptional elongation | ATP-competitive inhibitor | senescence | p53-wild-type cancer | 779353-01-4
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P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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