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Chemical Structure| 120011-70-3 Chemical Structure| 120011-70-3

Structure of Donepezil HCl
CAS No.: 120011-70-3

Chemical Structure| 120011-70-3

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Donepezil HCl is a selective and reversible AchE inhibitor, highly selective for the central nervous system and used in the management of mild to moderate Alzheimer's disease and dementia.

Synonyms: E2020; Donepezil HCl

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Product Citations

Product Citations

de Gouveia, Felipe Schlichta ; Spingolon, Gabriela ; Aguirre, Tanira ;

Abstract: Microemulsions are nanostructured, thermodynamically stable systems with a reduced droplet size. They can improve the drug absorption and distribution. Babassu oil has been investigated for various therapeutic properties reported by popular use. This work aimed to develop, optimize, and characterize babassu oil-based water-in-oil microemulsions to promote a controlled and uniform release of drugs with different physicochemical properties. The optimal microemulsion composition was investigated through pseudoternary diagrams, with water, surfactant mix, and oil mix as vertices. The formulations were characterized by pH, conductivity, size, polydispersity index, and drug content. In vitro drug release was carried out using multidimensional and unidimensional techniques. An optimum microemulsion contains (w/w): 10 % water, 17.8 % babassu oil, 26.2 % medium-chain triglycerides, 29.7 % SpanTM 83, 7.1 % Tween® 80, and 9.2 % Transcutol® HP. Diclofenac sodium (DS), donepezil hydrochloride (DH), and insulin were associated with the dispersed phase of microemulsion. These formulations presented a droplet size of 26.98 ± 1.95, 22.64 ± 0.49, 35.57 ± 0.75 nm, respectively. The polydispersity index was < 0.1 for all formulations. Microemulsions controlled the outflow of drugs, showing a uniform release compared to respective controls. It was evidenced that these profiles depend on the features of the molecule associated. According to the selection criteria, most experimental DS and DH release kinetics in water or pH 7.2 fit well with the Gompertz model. In conclusion, a babassu oil-based water-in-oil microemulsion was developed for the first time, optimized, and characterized, supporting further investigation of the formulation as a system.

Keywords: Microemulsion ; Controlled release ; ; Franz Cell ; Pseudoternary diagram

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Alternative Products

Product Details of Donepezil HCl

CAS No. :120011-70-3
Formula : C24H30ClNO3
M.W : 415.95
SMILES Code : O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=C1C=C(OC)C(OC)=C4.[H]Cl
Synonyms :
E2020; Donepezil HCl
MDL No. :MFCD00881312

Safety of Donepezil HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Th17 cells 5 μM 48 h To investigate the regulatory mechanism of donepezil on Th17 cell differentiation, it was found that donepezil reduced Th17 cell differentiation by inhibiting the JAK2-STAT3 signaling pathway Theranostics. 2023 Mar 21;13(6):1826-1842.
Mouse lung fibroblasts 5 μM 48 h To evaluate the effect of donepezil on Th17 cell differentiation, results showed that donepezil significantly inhibited Th17 cell differentiation Theranostics. 2023 Mar 21;13(6):1826-1842.
Mouse 6-3 microglial cells 5 μM 12 h Pretreatment with donepezil significantly suppressed TNFα-induced sustained intracellular Ca2+ elevation J Neuroinflammation. 2017 Dec 22;14(1):258.
Mouse primary microglial cells 5 μM 12 h Pretreatment with donepezil significantly suppressed TNFα-induced sustained intracellular Ca2+ elevation J Neuroinflammation. 2017 Dec 22;14(1):258.
Rat HAPI microglial cells 5 μM 12 h Pretreatment with donepezil significantly suppressed TNFα-induced sustained intracellular Ca2+ elevation J Neuroinflammation. 2017 Dec 22;14(1):258.
Primary OPCs 10 μM 9 days Enhances myelination, increases the length of myelinated axons Acta Pharmacol Sin. 2019 Nov;40(11):1386-1393.
NPC-derived OPCs 20 μM 4.5 days Promotes OPC to OL differentiation, significantly increases the percentage of MBP+ cells Acta Pharmacol Sin. 2019 Nov;40(11):1386-1393.
MDA-MB-231 cells 0.5, 1, 2 μM 48 h To evaluate the effect of donepezil on the anti-cancer efficacy of doxorubicin in breast cancer cells. Results showed that donepezil at tested concentrations did not affect the anti-cancer efficacy of doxorubicin. Neurotherapeutics. 2021 Jul;18(3):2107-2125.
MCF-7 cells 0.5, 1, 2 μM 48 h To evaluate the effect of donepezil on the anti-cancer efficacy of doxorubicin in breast cancer cells. Results showed that donepezil at tested concentrations did not affect the anti-cancer efficacy of doxorubicin. Neurotherapeutics. 2021 Jul;18(3):2107-2125.
Mouse neocortical homogenates 10 nM to 100 nM 20 min Measure the inhibitory effect of donepezil on brain AChE activity, with an IC50 of approximately 10-20 nM Br J Pharmacol. 2022 Dec;179(24):5273-5289.
Mouse hind limb muscle homogenates 10 nM to 10 μM 20 min Measure the inhibitory effect of donepezil on acetylcholinesterase (AChE) activity, with an IC50 of approximately 30-50 nM Br J Pharmacol. 2022 Dec;179(24):5273-5289.

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6 mice Bleomycin-induced lung fibrosis mouse model Intraperitoneal injection 1 mg/kg Once daily for 21 days To evaluate the ameliorative effect of donepezil on lung fibrosis and pulmonary hypertension, results showed that donepezil significantly improved pulmonary artery and right ventricle remodeling and increased survival rate Theranostics. 2023 Mar 21;13(6):1826-1842.
Mice Scopolamine-induced memory-deficient mouse model Intracalvariosseous administration (ICO) 5 mg/kg Single administration, lasting four weeks To evaluate the long-lasting brain exposure and cognitive improvement effects of DPZ@LAM. Results showed that a single ICO administration sustained DPZ concentration in the brain above therapeutic levels for four weeks, significantly recovering cognitive function in scopolamine-induced memory-deficient mice, along with decreased acetylcholinesterase activity and increased brain-derived neurotrophic factor. Theranostics. 2024 Oct 14;14(17):6708-6725
C57BL/6 mice Cuprizone-induced demyelination model Intraperitoneal injection 1.5 and 5 mg/kg Once daily for 1-3 weeks Promotes remyelination, significantly increases the number of myelinated axons and reduces G-ratio Acta Pharmacol Sin. 2019 Nov;40(11):1386-1393.
Sprague-Dawley rats Bilateral common carotid artery occlusion (BCCAO) model Oral 10 mg/kg Once daily for 3 weeks Donepezil significantly improved the performance of BCCAO rats in Morris Water Mazes test and Step-down test, attenuated neurodegeneration, restored the synapse dendritic spines density in cortex and hippocampus, and significantly increased BDNF expression in cortex and hippocampus. Acta Pharmacol Sin. 2020 May;41(5):588-598
Wistar rats Doxorubicin-induced chemobrain model Oral gavage 5 mg/kg Once daily for 30 consecutive days To evaluate the neuroprotective effects of donepezil in a doxorubicin-induced chemobrain model. Results showed that donepezil improved cognitive function, attenuated neuroinflammation and oxidative stress, restored mitochondrial function, and reduced neuronal death. Neurotherapeutics. 2021 Jul;18(3):2107-2125.
Mice Twitcher mouse model (model of Krabbe disease) Drinking water administration 20 μg/mL Started from postnatal day 25 and continued until the study endpoint Donepezil preserved myelin in Twitcher mice, reduced glial cell reactivity, improved behavioral phenotypes, and increased lifespan Mol Neurobiol. 2024 Nov;61(11):8688-8701

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02094053 Down Syndrome Phase 2 Completed - Japan ... More >> Fukuoka-shi, Fukuoka, Japan Sapporo-shi, Hokkaido, Japan Yokohama-shi, Kanagawa, Japan Takatsuki-shi, Kyoto, Japan Matsumoto-shi, Nagano, Japan Nagasaki-shi, Nagasaki, Japan Izumi-shi, Osaka, Japan Saitama-shi, Saitama, Japan Chiyoda-ku, Tokyo, Japan Setagaya-ku, Tokyo, Japan Less <<
NCT01419366 Healthy Phase 1 Completed - India ... More >> Bio Evaluation Centre, Torrent Pharmaceuticals Ltd., Village Bhat, Gandhinagar, Gujarat, India, 382428 Less <<
NCT00452868 - Completed - -
NCT01023425 Alzheimer's Disease ... More >> Dementia Less << Not Applicable Completed - Korea, Republic of ... More >> Samsung Medical Center Seoul, Korea, Republic of, 135-710 Less <<
NCT02927522 Osteoarthritis ... More >> Femoral Head Necrosis Rheumatoid Arthritis Less << Phase 3 Not yet recruiting October 2019 -
NCT00452868 Brain and Central Nervous Syst... More >>em Tumors Cognitive/Functional Effects Long-term Effects Secondary to Cancer Therapy in Children Neurotoxicity Psychosocial Effects of Cancer and Its Treatment Radiation Toxicity Less << Early Phase 1 Completed - United States, Massachusetts ... More >> Tufts-NEMC Cancer Center Boston, Massachusetts, United States, 02111 United States, North Carolina Wake Forest University Comprehensive Cancer Center Winston-Salem, North Carolina, United States, 27157-1096 Less <<
NCT03299257 OSA Sleepines... More >>s Less << Phase 4 Not yet recruiting March 2, 2019 Brazil ... More >> Instituto do Sono Active, not recruiting Sao Paulo, Brazil, 04024-002 Less <<
NCT01845636 Mild Cognitive Impairment Phase 4 Completed - United States, New York ... More >> New York State Psychiatric Institute New York, New York, United States, 10032 Less <<
NCT00096473 Alzheimer's Disease ... More >> Dementia Less << Phase 3 Completed - -
NCT02012595 - Completed - Denmark ... More >> Dept. of Nuclear Medicine & PET Center, Aarhus University Hospital Aarhus, Denmark, 8000 Less <<
NCT00800553 Sleep Deprivation Phase 4 Completed - Singapore ... More >> Cognitive Neuroscience Laboratory, Duke-NUS Graduate Medical School Singapore, Singapore, 169611 Less <<
NCT01129596 - Completed - -
NCT01845636 - Completed - -
NCT00959881 Healthy Subjects Phase 1 Completed - United States, Kansas ... More >> Pfizer Investigational Site Overland Park, Kansas, United States, 66211 Less <<
NCT01584076 Amblyopia Phase 1 Recruiting December 2020 United States, Massachusetts ... More >> Boston Children's Hospital Recruiting Boston, Massachusetts, United States, 02115 Contact: Sarah Whitecross, OC(C)    781-216-1463    sarah.whitecross@childrens.harvard.edu    Contact: Carolyn Wu, MD    617-355-5685    carolyn.wu@childrens.harvard.edu    Principal Investigator: Carolyn Wu, MD          Principal Investigator: David Hunter, MD, PhD          Sub-Investigator: Bharti Gangwani, MD          Boston Children's Hospital at Waltham Recruiting Waltham, Massachusetts, United States, 02453 Contact: Sarah Whitecross, OC(C)    781-216-1463    sarah.whitecross@childrens.harvard.edu    Contact: Carolyn Wu, MD    617-355-8761    carolyn.wu@childrens.harvard.edu    Principal Investigator: Carolyn Wu, MD          Principal Investigator: David Hunter, MD, PhD          Sub-Investigator: Bharti Gangwani, MD          Boston Children's Physicians South Recruiting Weymouth, Massachusetts, United States, 02190 Contact: Sarah Whitecross, OC(C)    781-216-1463    sarah.whitecross@childrens.harvard.edu    Contact: Carolyn Wu, MD    617-355-8761    carolyn.wu@childrens.harvard.edu    Principal Investigator: Carolyn Wu, MD          Principal Investigator: David Hunter, MD, PhD          Sub-Investigator: Bharti Gangwani, MD Less <<
NCT01023867 Alzheimer's Disease ... More >> Dementia Less << Not Applicable Completed - Korea, Republic of ... More >> Samsung Medical Center Seoul City, Korea, Republic of, 135-710 Less <<
NCT00934531 Falls Gait ... More >> Balance Mild Cognitive Impairment (MCI) Less << Not Applicable Active, not recruiting June 2017 Canada, Ontario ... More >> St. Joseph's Health Care London, Parkwood Hospital London, Ontario, Canada, N6C 5J1 Less <<
NCT00047697 - Completed - -
NCT01822951 Alzheimer Disease Phase 4 Withdrawn December 2016 Austria ... More >> AKh Allgemeines Krankenhaus der Stadt Linz GmbH Linz, Austria, 4021 Less <<
NCT00047697 Autistic Disorder Phase 2 Completed - United States, Pennsylvania ... More >> Western Psychiatric Institute & Clinic Pittsburgh, Pennsylvania, United States, 15213 Less <<
NCT01120626 Fragile X Syndrome Phase 2 Completed - United States, California ... More >> Stanford University School of Medicine Stanford, California, United States, 94305 Less <<
NCT01120626 - Completed - -
NCT00987220 - Completed - United States, Connecticut ... More >> Pfizer Investigational Site New Haven, Connecticut, United States, 06511 Less <<
NCT02711683 - Recruiting March 2018 China, Shaanxi ... More >> First Affiliated Hospital of Xi'an Jiaotong University Recruiting Xi'an, Shaanxi, China, 710061 Contact: Jin Wang    0086-13572208524    drwangjin@163.com Less <<
NCT01276080 Healthy Phase 1 Completed - United States, Nevada ... More >> Novum Pharmaceutical Research Services Las Vegas, Nevada, United States, 89121 Less <<
NCT03109314 Amblyopia Phase 4 Recruiting December 2018 United States, California ... More >> University of California, Berkeley Recruiting Berkeley, California, United States, 94720 Contact: Dennis M Levi, OD, PhD    510-643-8685    dlevi@berkeley.edu    Contact: Roger W Li, OD, PhD    510-643-8685    oroger@berkeley.edu    Sub-Investigator: Susana T Chung, OD, PhD          Sub-Investigator: Michael A Silver, PhD Less <<
NCT00843115 - Terminated(See Detailed Descri... More >>ption.) Less << - -
NCT01738295 Healthy Not Applicable Completed - Canada, Quebec ... More >> School of optometry / Université de Montréal Montréal, Quebec, Canada, H3T 1P1 Less <<
NCT00467389 Cocaine Abuse and Dependence Phase 2 Completed - United States, Missouri ... More >> VA Medical Center Kansas City, Missouri, United States, 64128 Less <<
NCT00594633 Brain Tumor B... More >>rain Cancer Cns Cancer Cognitive Dysfunction Less << Phase 1 Completed - United States, New York ... More >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Less <<
NCT01276067 Healthy Phase 1 Completed - United States, Pennsylvania ... More >> Novum Pharmaceutical Research Services Pittsburgh,, Pennsylvania, United States Less <<
NCT00408525 Alzheimer's Disease Phase 1 Completed - United States, Tennessee ... More >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37212 Less <<
NCT03698695 Cognitive Impairment ... More >> Alzheimer Disease Less << Phase 1 Recruiting July 31, 2019 France ... More >> CHU Bordeaux Not yet recruiting Bordeaux, France Contact: Pierre-Olivier Girodet, Prof.          CHU Clermont Ferrand Recruiting Clermont-Ferrand, France Contact: Gisèle Pickering, Prof.          CHU Grenoble Not yet recruiting Grenoble, France Contact: Jean-Luc Cracowski, Prof.          CHU Lille Recruiting Lille, France Contact: Dominique Deplanque, Prof.          CHU Marseille Recruiting Marseille, France Contact: Olivier Blin, Prof.          Biotrial Recruiting Rennes, France Contact: Hakim Charfi, Dr.          CHU Toulouse Not yet recruiting Toulouse, France Contact: Claire Thalamas, Dr. Less <<
NCT00478205 - Completed - -
NCT01063556 End-Stage Renal Disease Phase 4 Completed - Japan ... More >> Moriya, Ibaraki, Japan Less <<
NCT00843115 - Terminated(See Detailed Descri... More >>ption.) Less << - -
NCT02822573 Cognitive Dysfunction ... More >> Memory Impairment Less << Phase 3 Recruiting October 12, 2020 United States, North Carolina ... More >> Wake Forest School of Medicine Recruiting Winston-Salem, North Carolina, United States, 27157 Contact: Tammy Vogler, RN    336-713-6907    tvogler@wakehealth.edu Less <<
NCT00478205 Alzheimer's Disease Phase 3 Completed - United States, North Carolina ... More >> MedTrials, Inc. Hickory, North Carolina, United States, 28601 Less <<
NCT01539031 Alzheimer's Type Dementia Phase 3 Completed - -
NCT00467389 - Completed - -
NCT00598650 Dementia With Lewy Bodies (DLB... More >>) Less << PHASE2 COMPLETED 2025-03-11 -
NCT00598650 Dementia With Lewy Bodies (DLB... More >>) Less << PHASE2 COMPLETED 2025-03-11 -
NCT02097056 - Completed - -
NCT01506752 Healthy Adult Phase 1 Completed - Japan ... More >> Sumida-ku, Tokyo, Japan Less <<
NCT00352664 Advanced Cancer Phase 3 Terminated(Low patient accrual... More >>) Less << - United States, Texas ... More >> U.T. M.D. Anderson Cancer Center Houston, Texas, United States, 77030 Less <<
NCT00912457 Obstructive Sleep Apnea Phase 4 Unknown December 2009 Brazil ... More >> Instituto do Sono / Associacao Fundo de Incentivo a Psicofarmacologia Recruiting Sao Paulo, Brazil, 04020-060 Contact: Lucia Sukys-Claudino, MD    (55-48)-9129-7576    lucia@neuromeddiagnosticos.com.br    Contact: Walter Moraes, MD, PhD    (55-11)-5573-9238    walter.moraes@afip.com.br    Principal Investigator: Sergio Tufik, MD, PhD          Sub-Investigator: Dalva Poyares, MD, PhD Less <<
NCT01442766 Acute Stroke Phase 1 Phase 2 Unknown May 2014 United Kingdom ... More >> Charing Cross Hospital, Imperial College Academic Health Science Centre Not yet recruiting London, United Kingdom, W6 8RF Contact: Paul Bentley, MA MRCP PhD    02033111184    p.bentley@imperial.ac.uk Less <<
NCT01743976 Neuropathic Pain Phase 4 Active, not recruiting December 2018 United States, North Carolina ... More >> Wake Forest Baptist Medical Center Winston-Salem, North Carolina, United States, 27157 Wake Forest Baptist Health Winston-Salem, North Carolina, United States, 27295 Less <<
NCT02097056 Alzheimer's Disease Phase 4 Completed - Korea, Republic of ... More >> Chungju, Chungcheongbuk-do, Korea, Republic of Ansan, Gyeonggi-do, Korea, Republic of Buchoen, Gyeonggi-do, Korea, Republic of Seongnam, Gyeonggi-do, Korea, Republic of Jinju, Gyeongsangnam-do, Korea, Republic of Iksan, Jeollabuk-do, Korea, Republic of Hwasun, Jeollanam-do, Korea, Republic of Busan, Korea, Republic of Daegu, Korea, Republic of Daejeon, Korea, Republic of Incheon, Korea, Republic of Jeju, Korea, Republic of Seoul, Korea, Republic of Less <<
NCT02345213 Dementia, Lewy Body ... More >> Lewy Body Disease Less << Phase 4 Completed - Japan ... More >> Saitama, Japan Less <<
NCT01506739 Healthy Adult Phase 1 Completed - Japan ... More >> Sumida-ku, Tokyo, Japan Less <<
NCT02331771 Memory Impairment Not Applicable Terminated(Lack of sufficient ... More >>enrollment) Less << - United States, Colorado ... More >> Porter Adventist Hospital Denver, Colorado, United States, 80210 Less <<
NCT01466270 - Completed - -
NCT00369785 Brain Tumors ... More >>Metastatic Disease Less << Phase 3 Completed - United States, Kansas ... More >> Associates in Womens Health, PA - North Review Wichita, Kansas, United States, 67208 Cancer Center of Kansas, PA - Medical Arts Tower Wichita, Kansas, United States, 67208 Cancer Center of Kansas, PA - Wichita Wichita, Kansas, United States, 67214 CCOP - Wichita Wichita, Kansas, United States, 67214 Via Christi Cancer Center at Via Christi Regional Medical Center Wichita, Kansas, United States, 67214 United States, Maine Central Maine Comprehensive Cancer Center at Central Maine Medical Center Lewiston, Maine, United States, 04240 United States, New Hampshire New Hampshire Oncology - Hematology, PA - Hooksett Hooksett, New Hampshire, United States, 03106 Lakes Region General Hospital Laconia, New Hampshire, United States, 03246 United States, New York Don Monti Comprehensive Cancer Center at North Shore University Hospital Manhasset, New York, United States, 11030 United States, North Dakota CCOP - MeritCare Hospital Fargo, North Dakota, United States, 58122 Trinity CancerCare Center Minot, North Dakota, United States, 58701 United States, Ohio Summa Center for Cancer Care at Akron City Hospital Akron, Ohio, United States, 44309-2090 MetroHealth Cancer Care Center at MetroHealth Medical Center Cleveland, Ohio, United States, 44109 United States Air Force Medical Center - Wright-Patterson Wright-Patterson Air Force Base, Ohio, United States, 45433-5529 United States, Tennessee Thompson Cancer Survival Center Knoxville, Tennessee, United States, 37916 United States, Wisconsin Gundersen Lutheran Center for Cancer and Blood La Crosse, Wisconsin, United States, 54601 Less <<
NCT00369785 - Completed - -
NCT01466270 Anxiety Disorder ... More >> Breast Cancer Cognition Disorders Depression Fatigue Sleep Disorders Less << Phase 2 Completed - -
NCT01191918 Bipolar Disorder ... More >> Mania Less << Phase 4 Completed - -
NCT00570128 Down Syndrome Phase 2 Completed - -
NCT02968719 Alzheimer Disease Phase 1 Completed - United States, Arizona ... More >> Celerion Phoenix, Arizona, United States, 85283 Less <<
NCT00571064 Mild to Severe Alzheimer's Dis... More >>ease Less << PHASE4 COMPLETED 2009-04-22 Senior Care, Birmingham, Alaba... More >>ma, 35209, United States|21st Century Neurology, Phoenix, Arizona, 85004, United States|Psypharma Clinical Research, Phoenix, Arizona, 85050, United States|South Coast Clinical Trials, Anaheim, California, 38204, United States|AVI Clinical Research, Carson, California, 90746, United States|Margolin Brain Institute, Fresno, California, 93720, United States|Sarah Sam Olelewe, MD Inc, Hawthorne, California, 90250, United States|Neuropsychiatric Research Center of Orange County, Santa Ana, California, 92701, United States|Danbury Clinical Research, LLC, Danbury, Connecticut, 06810, United States|Research Center for Clinical Studies, Norwalk, Connecticut, 06851, United States|Galiz Research, Miami Springs, Florida, 33166, United States|Neuroscience Consultants, Miami, Florida, 33176, United States|Universal Clinical research and Technology, Orlando, Florida, 32833, United States|Byrd's Alzheimer Institute, Tampa, Florida, 33613, United States|Stedman Clinical Trials, LLC, Tampa, Florida, 33613, United States|Center for Clinical Trials, Venice, Florida, 34285, United States|Rush Alzheimer Disease Center, Chicago, Illinois, 92804, United States|Alexian Brothers Neuroscience Institute, Elk Grove, Illinois, 60007, United States|Agewell Health Ltd, Indianapolis, Indiana, 46260, United States|Venture Resource Group Inc, Mission, Kansas, 66202, United States|Four Rivers Clinical Research, Paducah, Kentucky, 42003, United States|McLean Hospital Geriatric Psychiatry, Belmont, Massachusetts, 02478, United States|Neuroscience Research of the Bershires, Pittsfield, Massachusetts, 01201, United States|Horne Research, Las Vegas, Nevada, 89102, United States|Bio Behavioral Health, Toms River, New Jersey, 08755, United States|University of New Mexico, Albuquerque, New Mexico, 87131, United States|Neurological Associates of Albany, PC, Albany, New York, 12208, United States|University Of Buffalo, Buffalo, New York, 14215, United States|University of Rochester, Monroe Community Hospital, Rochester, New York, 14620, United States|Valley Medical Research, Centerville, Ohio, 45959, United States|Infinity Research Group, Oklahoma City, Oklahoma, 73103, United States|University of Pennsylvania, Section of Geriatric Psychiatry, Philadelphia, Pennsylvania, 19104, United States|Rhode Island Mood and Memory Research Institute, East Providence, Rhode Island, 02914, United States|CNS Research, INC, East Providence, Rhode Island, 02916, United States|Senior Adults Specialty Research, Austin, Texas, 78757, United States|Mech Center, Plano, Texas, 75024, United States Less <<
NCT00352664 - Terminated(Low patient accrual... More >>) Less << - -
NCT00571064 Mild to Severe Alzheimer's Dis... More >>ease Less << PHASE4 COMPLETED 2009-04-22 Senior Care, Birmingham, Alaba... More >>ma, 35209, United States|21st Century Neurology, Phoenix, Arizona, 85004, United States|Psypharma Clinical Research, Phoenix, Arizona, 85050, United States|South Coast Clinical Trials, Anaheim, California, 38204, United States|AVI Clinical Research, Carson, California, 90746, United States|Margolin Brain Institute, Fresno, California, 93720, United States|Sarah Sam Olelewe, MD Inc, Hawthorne, California, 90250, United States|Neuropsychiatric Research Center of Orange County, Santa Ana, California, 92701, United States|Danbury Clinical Research, LLC, Danbury, Connecticut, 06810, United States|Research Center for Clinical Studies, Norwalk, Connecticut, 06851, United States|Galiz Research, Miami Springs, Florida, 33166, United States|Neuroscience Consultants, Miami, Florida, 33176, United States|Universal Clinical research and Technology, Orlando, Florida, 32833, United States|Byrd's Alzheimer Institute, Tampa, Florida, 33613, United States|Stedman Clinical Trials, LLC, Tampa, Florida, 33613, United States|Center for Clinical Trials, Venice, Florida, 34285, United States|Rush Alzheimer Disease Center, Chicago, Illinois, 92804, United States|Alexian Brothers Neuroscience Institute, Elk Grove, Illinois, 60007, United States|Agewell Health Ltd, Indianapolis, Indiana, 46260, United States|Venture Resource Group Inc, Mission, Kansas, 66202, United States|Four Rivers Clinical Research, Paducah, Kentucky, 42003, United States|McLean Hospital Geriatric Psychiatry, Belmont, Massachusetts, 02478, United States|Neuroscience Research of the Bershires, Pittsfield, Massachusetts, 01201, United States|Horne Research, Las Vegas, Nevada, 89102, United States|Bio Behavioral Health, Toms River, New Jersey, 08755, United States|University of New Mexico, Albuquerque, New Mexico, 87131, United States|Neurological Associates of Albany, PC, Albany, New York, 12208, United States|University Of Buffalo, Buffalo, New York, 14215, United States|University of Rochester, Monroe Community Hospital, Rochester, New York, 14620, United States|Valley Medical Research, Centerville, Ohio, 45959, United States|Infinity Research Group, Oklahoma City, Oklahoma, 73103, United States|University of Pennsylvania, Section of Geriatric Psychiatry, Philadelphia, Pennsylvania, 19104, United States|Rhode Island Mood and Memory Research Institute, East Providence, Rhode Island, 02914, United States|CNS Research, INC, East Providence, Rhode Island, 02916, United States|Senior Adults Specialty Research, Austin, Texas, 78757, United States|Mech Center, Plano, Texas, 75024, United States Less <<
NCT01404169 Alzheimer's Type Dementia Phase 3 Completed - -
NCT02415062 Parkinson's Disease Phase 2 Unknown December 2017 Korea, Republic of ... More >> Inje university, busan paik hospital Recruiting Busan, Korea, Republic of Contact: Sang-jin kim, professor    82-10-9525-6207    jsk120@hanmail.net Less <<
NCT00543855 - Completed - -
NCT01633593 Elderly Delir... More >>ium of Unknown (Axis III) Etiology Intensive Care (ICU) Myopathy Less << Phase 4 Terminated(Difficulty in recru... More >>iting subjects for the trial.) Less << - Brazil ... More >> FAMEMA Marilia, Sao Paulo, Brazil, 1750000 Less <<
NCT01490567 Impaired Cognition ... More >> Schizophrenia Less << Phase 4 Unknown June 2012 China, Hunan ... More >> the Second Xiangya Hospital of Central South University Recruiting Changsha, Hunan, China, 410011 Contact: Xiaofeng Guo, Doctor    86-731-85554052    gxfd@sina.com.cn Less <<
NCT00220584 Fragile X Syndrome Phase 1 Completed - United States, California ... More >> Stanford University School of Medicine Stanford, California, United States, 94305 Less <<
NCT01521117 Parkinson's Disease Phase 4 Unknown July 2012 United States, Oregon ... More >> Parkinson's Center of Oregon - Oregon Health and Science University Recruiting Portland, Oregon, United States, 97239 Contact: Seth Kareus, MD       kareus@ohsu.edu Less <<
NCT01278407 Dementia With Lewy Bodies (DLB... More >>) Less << Phase 3 Completed - -
NCT01276353 - Completed - -
NCT01877538 - Completed - Denmark ... More >> Dep. of Nuclear Medicine and PET centre, Aarhus University Hospital Aarhus, Denmark, 8000 Less <<
NCT00543855 Dementia With Lewy Bodies (DLB... More >>) Less << Phase 2 Completed - Japan ... More >> Nagoya, Aichi, Japan Obu, Aichi, Japan Toyokawa, Aichi, Japan Kurume, Fukuoka, Japan Omuta, Fukuoka, Japan Maebashi, Gunma, Japan Miyoshi, Hiroshima, Japan Otake, Hiroshima, Japan Himeji, Hyogo, Japan Kobe, Hyogo, Japan Tsukuba, Ibaraki, Japan Kahoku, Ishikawa, Japan Morioka, Iwate, Japan Yokohama, Kanagawa, Japan Nankoku, Kochi, Japan Koshi, Kumamoto, Japan Joyo, Kyoto, Japan Sendai, Miyagi, Japan Komoro, Nagano, Japan Kashihara, Nara, Japan Joetsu, Niigata, Japan Sanjo, Niigata, Japan Yufu, Oita, Japan Sakai, Osaka, Japan Suita, Osaka, Japan Izumo, Shimane, Japan Bunkyo-ku, Tokyo, Japan Kodaira, Tokyo, Japan Koto-ku, Tokyo, Japan Ota-ku, Tokyo, Japan Setagaya-ku, Tokyo, Japan Shinjuku-ku, Tokyo, Japan Ube, Yamaguchi, Japan Akita, Japan Chiba, Japan Fukui, Japan Fukuoka, Japan Kochi, Japan Kumamoto, Japan Kyoto, Japan Osaka, Japan Saitama, Japan Shizuoka, Japan Less <<
NCT00477659 Alzheimer's Disease Phase 4 Completed - United States, Wisconsin ... More >> Pfizer Investigational Site Milwaukee, Wisconsin, United States, 53226 Less <<
NCT02305836 Cognitive Impairment Phase 2 Recruiting December 2019 China ... More >> Guang'an Men Hospotal Affiliated to China Academy of Chinese Medical Sciences Recruiting Beijing, China, 100053 Contact: Weina Peng    86-18610935028    wnpeng@hotmail.com Less <<
NCT01276353 Alzheimer's Type Dementia Phase 2 Completed - Japan ... More >> Kitakyushu, Fukuoka, Japan Mizunami, Gifu, Japan Yokosuka, Kanagawa, Japan Sanjo, Niigata, Japan Kurashiki, Okayama, Japan Fuji, Shizuoka, Japan Hachioji, Tokyo, Japan Kodaira, Tokyo, Japan Akita, Japan Fukuoka, Japan Saitama, Japan Less <<
NCT01042314 Alzheimer Disease Phase 1 Completed - United States, Maryland ... More >> Parexel International - Baltimore Epcu Baltimore, Maryland, United States, 21225 Less <<
NCT00165763 Vascular Dementia Phase 4 Completed - Philippines ... More >> Memory Center Quezon, Manila, Philippines Subic Bay Medical Center Olongapo, Zambales, Philippines Less <<
NCT01877538 - Completed - -
NCT02064920 Alzheimer's Disease Phase 2 Completed - -
NCT01297036 Alzheimer Disease Phase 1 Completed - Korea, Republic of ... More >> Dept. of Clinical Pharmacology & Toxicology, Anam Hospital, Korea University College of Medicine Seoul, Korea, Republic of, 136-705 Less <<
NCT00465283 Schizophrenia ... More >> Schizoaffective Disorder Schizophreniform Disorder Less << Phase 4 Unknown January 2010 Israel ... More >> Beer Yaakov MHC Recruiting Beer Yaacov, Israel, 70350 Contact: Tali Nachshoni, M.D.    972-8-9258372    bynachshoni@beer-ness.health.gov.il    Principal Investigator: Tali Nachshoni, MD Less <<
NCT01278407 - Completed - -
NCT01014858 Parkinson's Disease Phase 3 Terminated(Due to low recruitm... More >>ent) Less << - United Kingdom ... More >> Newcastle Newcastle Upon Tyne, Tyne and Wear, United Kingdom, NE4 5PL Royal United Hospital (RUH) Bath NHS Bath, United Kingdom, BA1 3NG Sandwell and West Birmingham NHS Foundation Trust Birmingham, United Kingdom, B18 7QH Steps and Pines, Southmead Hospital Bristol, United Kingdom, BS10 5NB Pennine Acute Hospitals NHS Trust Bury, United Kingdom, BL9 7TD Cambridge Centre for Brain Repair Cambridge, United Kingdom, CB2 0PY Dr Lakmali Sugathapala Derby, United Kingdom, DE22 3NE Royal Bournemouth & Christchurch Hospitals NHS Foundation Trust Dorset, United Kingdom, BH23 2JX NHS Greater Glasgow and Clyde Glasgow, United Kingdom, G51 4TF Dr Pippa Metcalf Gloucester, United Kingdom, Gloucester Llandudno Hospital, Betsi Cadwaladr University Health Board & School of Medical Sciences Llandudno, United Kingdom, LL30 1LB King's College Hospital NHS Foundtion Trust London, United Kingdom, SE59RS Manchester Mental Health & Social Care NHS Trust Manchester, United Kingdom, M8 5RB Milton Keynes Milton Keynes, United Kingdom, MK6 5LD Royal Gwent Hospital Newport, United Kingdom, NP20 2UB North Tyneside General Hospital Northumberland, United Kingdom, NE29 8NH Norfolk and Norwich University Hospitals NHS Foundation Trust Norwich, United Kingdom, NR4 7UY Oxford University Hospitals NHS Foundation Trust Oxford, United Kingdom, OX3 9DU Plymouth Hospitals NHS Trust Plymouth, United Kingdom, PL6 8DH Poole Hospital NHS Trust Poole, United Kingdom, BH15 2JB Southampton General Hospital Southampton, United Kingdom, SO16 6YD Dr Dhakam Surrey, United Kingdom, KT16 0PZ Less <<
NCT02064920 - Completed - -
NCT03599726 Parkinson Disease Early Phase 1 Recruiting January 1, 2019 United States, Oregon ... More >> Oregon Health & Science University Recruiting Portland, Oregon, United States, 97239 Contact: Makena Strand    503-418-2602    strandm@ohsu.edu    Principal Investigator: Martina Mancini, PhD Less <<
NCT03397862 Skin Irritation ... More >> Sensitization Less << Phase 1 Completed - United States, Arizona ... More >> Celerion Inc. Phoenix, Arizona, United States, 85283 United States, Nebraska Celerion Inc. Lincoln, Nebraska, United States, 68502 Less <<
NCT00754052 - Terminated(Sufficient evidence... More >> of efficacy not met. Discontinuation not based on any safety concerns.) Less << - -
NCT00711204 Severe Alzheimer's Disease Phase 4 Withdrawn(No patients were enr... More >>olled in the study.) Less << - United States, Ohio ... More >> Kettlie Joseph Daniels, M.D. Inc. Toledo, Ohio, United States, 43609 Less <<
NCT02162264 Alzheimer's Disease COMPLETED 2016-07-22 Multiple Locations, Japan
NCT02158910 - Completed - Korea, Republic of ... More >> Busan, Korea, Republic of Chungcheongbuk-do, Korea, Republic of Chungcheongnam-do, Korea, Republic of Daegu, Korea, Republic of Gangwon-do, Korea, Republic of Gwangju, Korea, Republic of Gyeonggji-do, Korea, Republic of Gyeongsangbuk-do, Korea, Republic of Gyeongsangnam-do, Korea, Republic of Jeju-do, Korea, Republic of Jeollabuk-do, Korea, Republic of Jeollanam-do, Korea, Republic of Seoul, Korea, Republic of Less <<
NCT01951118 Alzheimer Disease ... More >> Mild Cognitive Impairment Delirium, Dementia, Amnestic, Cognitive Disorders Less << Phase 4 Active, not recruiting May 2019 United States, New York ... More >> New York State Psychiatric Institute New York, New York, United States, 10032 Less <<
NCT03438604 Alzheimer's Disease Phase 1 Completed - United States, Arizona ... More >> Celerion Phoenix, Arizona, United States, 85283 Less <<
NCT03432195 Alzheimer's Disease Phase 1 Completed - United States, Arizona ... More >> Celerion Tempe, Arizona, United States, 85283 Less <<
NCT01439230 Healthy Phase 1 Completed - Canada, Quebec ... More >> Anapharm Montreal, Quebec, Canada, H3X 2H9 Less <<
NCT01439243 Healthy Phase 1 Completed - Canada, Quebec ... More >> Anapharm Montreal, Quebec, Canada, H3X 2H9 Less <<
NCT00675025 Down Syndrome Phase 2 Terminated(Sufficient evidence... More >> of efficacy not met. Discontinuation not based on any safety concerns.) Less << - -
NCT00457769 Stroke Vascul... More >>ar Dementia Memory Deficits Less << Phase 1 Active, not recruiting December 2019 United States, New Jersey ... More >> Kessler Foundation West Orange, New Jersey, United States, 08902 Less <<
NCT02162251 Alzheimer's Desease COMPLETED 2016-04-15 Multiple Locations, Japan
NCT03259958 Alzheimer's Disease Phase 1 Completed - United States, Arizona ... More >> Celerion Inc. Phoenix, Arizona, United States, 85283 Less <<
NCT00934375 - Completed - -
NCT01251718 - Completed - -
NCT03073876 Alzheimer Disease Phase 4 Active, not recruiting July 31, 2019 United States, New York ... More >> Winthrop-University Hospital Mineola, New York, United States, 11501 Less <<
NCT02222727 Aneurysmal Subarachnoid Hemorr... More >>hage Delayed Neurological Deficit Delayed Cerebral Ischemia Vasospasm Less << Phase 2 Terminated(CT scanner software... More >> incompatible) Less << - United Kingdom ... More >> St George's University of London London, United Kingdom, SW17 0RE Less <<
NCT02255799 Traumatic Brain Injury ... More >> Memory Deficits Less << Phase 3 Recruiting September 2018 United States, Indiana ... More >> Indiana University Recruiting Indianapolis, Indiana, United States, 46202 Contact: Becky Runkel, MHA    317-329-2217    becky.runkel@rhin.com    Principal Investigator: Flora Hammond, MD          United States, Massachusetts Spaulding Rehabilitation Hospital Recruiting Charlestown, Massachusetts, United States, 02129 Contact: Joseph Giacino, PhD    617-952-5232    jgiacino@partners.org    Contact: Ross Zafonte, DO    617-952-5227    rzafonte@partners.org    Principal Investigator: Joseph Giacino, PhD          Sub-Investigator: Ross Zafonte, DO          United States, Pennsylvania Moss Rehabilitation Research Institute Recruiting Elkins Park, Pennsylvania, United States, 19027 Contact: Tessa Hart, PhD    215-663-6153    thart@einstein.edu    Contact: John Whyte, MD, PhD    215-663-6872    jwhyte@einstein.edu    Principal Investigator: Tessa Hart, PhD          Sub-Investigator: John Whyte, MD, PhD          United States, Texas TIRR Memorial Hermann Recruiting Houston, Texas, United States, 77030 Contact: Jay Bogaards, MA    713-797-7102    Jay.Bogaards@memorialhermann.org    Contact: Angelle Sander, PhD    713-797-7161    Angelle.Sander@memorialhermann.org    Principal Investigator: Angelle Sander, PhD          Sub-Investigator: Mark Sherer, PhD Less <<
NCT00934375 Mild Cognitive Impairment Phase 4 Completed - -
NCT01146509 Migraine Headache Phase 2 Completed - United States, Illinois ... More >> Diamond Headache Clinical Chicago, Illinois, United States, 60614 United States, Missouri Clinvest/Headache Care Center Springfield, Missouri, United States, 65804 United States, New York Elkind Headache Center Mount Vernon, New York, United States, 10550 United States, Pennsylvania The Clinical Trial Center, LLC Jenkintown, Pennsylvania, United States, 19046 Less <<
NCT00754013 Down Syndrome ... More >> Cognitive Dysfunction Less << Phase 3 Terminated(Sufficient evidence... More >> of efficacy not met.) Less << - United States, Texas ... More >> Road Runner Research San Antonio, Texas, United States, 78258 United States, Virginia NeuroScience, Inc. Herndon, Virginia, United States, 20170 Less <<
NCT02550665 Alzheimer's Disease Phase 3 Completed - Korea, Republic of ... More >> Asan Medical Center Seoul, Korea, Republic of, 05505 Less <<
NCT01923558 Healthy Phase 1 Completed - Canada, Quebec ... More >> Algorithme Pharma Inc. Mount Royal, Quebec, Canada, H3P 3P1 Less <<
NCT01923259 Healthy Phase 1 Completed - Canada, Quebec ... More >> Algorithme Pharma Inc. Mount Royal, Quebec, Canada, H3P 3P1 Less <<
NCT00688376 Attention Impairment Phase 3 Completed - -
NCT01504516 Healthy Phase 1 Completed - India ... More >> Bioserve Clinical Research Private Limited Hyderabad, Andhra Pradesh, India, 500 037 Less <<
NCT00754052 Down Syndrome ... More >> Cognitive Dysfunction Less << Phase 3 Terminated(Sufficient evidence... More >> of efficacy not met. Discontinuation not based on any safety concerns.) Less << - United States, Texas ... More >> Road Runner Research San Antonio, Texas, United States, 78258 United States, Virginia Neuroscience, Inc Herndon, Virginia, United States, 20170 Less <<
NCT00754013 - Terminated(Sufficient evidence... More >> of efficacy not met.) Less << - -
NCT01504503 Healthy Phase 1 Completed - India ... More >> Bioserve Clinical Research Private Limited Hyderabad, Andhra Pradesh, India, 500 037 Less <<
NCT01260922 Healthy Phase 1 Completed - United States, Minnesota ... More >> PRACS Institute, Ltd. East Grand Forks, Minnesota, United States, 56721 Less <<
NCT01260948 - Completed - -
NCT01260922 - Completed - -
NCT02448784 Dementia With Lewy Body Diseas... More >>e Less << COMPLETED 2017-03-30 Tokyo, Japan
NCT02787746 Alzheimer's Disease Phase 4 Active, not recruiting December 2018 China, Beijing ... More >> Beijing Friendship Hospital, Capital Medical University Beijing, Beijing, China Less <<
NCT01260948 Healthy Phase 1 Completed - United States, Minnesota ... More >> PRACS Institute, Ltd. East Grand Forks, Minnesota, United States, 56721 Less <<
NCT02660983 Dementia Associated With Cereb... More >>rovascular Disease Less << Phase 4 Active, not recruiting January 1, 2019 Korea, Republic of ... More >> Seo-Gu, Busan, Korea, Republic of Buk-Gu, Daegu, Korea, Republic of Jung-Gu, Daegu, Korea, Republic of Nam-Gu, Daegu, Korea, Republic of Chuncheon-Si, Gangwon-do, Korea, Republic of Donggu, Gwangju, Korea, Republic of Anyang, Gyeonggi-do, Korea, Republic of Bucheon-Si, Gyeonggi-do, Korea, Republic of Goyang-Si, Gyeonggi-do, Korea, Republic of Seongnam-Si, Gyeonggi-do, Korea, Republic of Suwon-City, Gyeonggi-do, Korea, Republic of Wonmi-Gu, Gyeonggi-do, Korea, Republic of Changwon-Si, Gyeongsangnam-do, Korea, Republic of Yangsan-Si, Gyeongsangnam-do, Korea, Republic of Jung-Gu, Incheon, Korea, Republic of Namdong-Gu, Incheon, Korea, Republic of Dongjak-Gu, Seoul, Korea, Republic of Gangdong-Gu, Seoul, Korea, Republic of Gangnam-Gu., Seoul, Korea, Republic of Gwangjin-Gu, Seoul, Korea, Republic of Jongno-Gu, Seoul, Korea, Republic of Jungnang-Gu, Seoul, Korea, Republic of Seocho-Gu, Seoul, Korea, Republic of Seodaemun-Gu, Seoul, Korea, Republic of Seongbuk-Gu, Seoul, Korea, Republic of Seongdong-Gu, Seoul, Korea, Republic of Songpa-Gu, Seoul, Korea, Republic of Yangcheon-Ku, Seoul, Korea, Republic of Yeongdeungpo-Gu, Seoul, Korea, Republic of Less <<
NCT01554475 - Completed - Norway ... More >> Kløveråsen Bodø, Norway, N-8076 Less <<
NCT01213355 Healthy Phase 1 Completed - France ... More >> Pfizer Investigational Site Rennes, France, 35000 Less <<
NCT01872598 Alzheimer Disease Phase 3 Active, not recruiting October 2019 Spain ... More >> Hospital Universitario Ramón y Cajal Madrid, Spain, 28034 Less <<
NCT00105105 Alzheimer's Disease Phase 2 Terminated - United States, Arizona ... More >> Pivotal Research Center Mesa, Arizona, United States, 85210 Pivotal Research Center Peoria, Arizona, United States, 85381 United States, California ATP Clinical Trials Fountain Valley, California, United States, 92708 UCI Irvine Medical Center Orange, California, United States, 92868 California Neuroscience Research Medical Group, Inc. Sherman Oaks, California, United States, 91403 AVI Clinical Research Torrance, California, United States, 90505 United States, Florida Baumel-Eisner Neuromed Inst Boca Raton, Florida, United States, 33486 Baumel-Eisner Neuromed Inst Ft. Lauderdale, Florida, United States, 33321 Clinical Physiology Associates Ft. Myers, Florida, United States, 33916 Baumel-Eisner Neuromed Inst Miami Beach, Florida, United States, 33154 Stedman Clinical Trials Tampa, Florida, United States, 33613 Johnnie B. Byrd, Sr. Alzheimer's Center & Research Inst Tampa, Florida, United States, 33647 United States, New Jersey Memory Enhancement Center Long Branch, New Jersey, United States, 07740 United States, New York Eastside Medical Research New York, New York, United States, 10021 United States, Ohio Neuro Center of Ohio Toledo, Ohio, United States, 43623 United States, Oklahoma Pahl Pharmaceutical Research, LLC Oklahoma City, Oklahoma, United States, 73118 Clinical Pharmaceutical Trials, Inc. Tulsa, Oklahoma, United States, 74104 United States, Pennsylvania Clinical Trials Research Services Pittsburgh, Pennsylvania, United States, 15206 United States, Texas Grayline Clinical Drug Trials Wichita Falls, Texas, United States, 76309 United States, Virginia International Clinical Research Associates Richmond, Virginia, United States, 23229 International Clinical Research Associates Virginia Beach, Virginia, United States, 23452 Less <<
NCT01626391 Alzheimer's Disease Phase 2 Terminated(This study has been... More >> terminated for administrative reasons only.) Less << - Germany ... More >> Achim, Germany Berlin, Germany Leipzig, Germany München, Germany United Kingdom Birmingham, United Kingdom Bradford, United Kingdom Crowborough, United Kingdom Duston, United Kingdom Oxford, United Kingdom Sheffield, United Kingdom St Leonards on Sea, United Kingdom Staffordshire, United Kingdom Less <<
NCT01626391 - Terminated(This study has been... More >> terminated for administrative reasons only.) Less << - -
NCT00051909 Alzheimer's Disease Phase 2 Completed - United States, California ... More >> Beverly Hills, California, United States Fresno, California, United States United States, Florida Boca Raton, Florida, United States Fort Lauderdale, Florida, United States Miami Beach, Florida, United States United States, Massachusetts Boston, Massachusetts, United States United States, Oklahoma Oklahoma City, Oklahoma, United States Tulsa, Oklahoma, United States United States, Texas Wichita Falls, Texas, United States Less <<
NCT02491268 Mild Cognitive Impairment Phase 2 Recruiting December 2020 Japan ... More >> National Cerebral and Cardiovascular Center Recruiting Suita, Osaka, Japan, 565-8565 Contact: Masafumi Ihara, MD, PhD, FACP    +81668335012    ihara@ncvc.go.jp    Contact: Ryosuke Kakuta    +81668335012    r_kakuta@ncvc.go.jp    Principal Investigator: Kazuyuki Nagatsuka, MD, PhD Less <<
NCT01152216 Alzheimer's Disease Phase 3 Terminated - -
NCT01428362 Alzheimer's Disease Phase 2 Completed - United States, California ... More >> San Francisco, California, United States, 94109 Santa Monica, California, United States, 90404 United States, Florida Sunrise, Florida, United States, 33351 United States, Kentucky Louisville, Kentucky, United States, 40217 United States, Nevada Las Vegas, Nevada, United States, 89113 United States, New Jersey Toms River, New Jersey, United States, 08755 United States, New York New Windsor, New York, United States, 12553 United States, North Carolina Durham, North Carolina, United States, 27710 Raleigh, North Carolina, United States, 27612 United States, Ohio Toledo, Ohio, United States, 43623 United States, Texas Plano, Texas, United States, 75075 Less <<
NCT01253434 Japanese Healthy Male Adult Vo... More >>lunteers Less << Phase 1 Completed - Japan ... More >> Kagoshima, Japan Less <<
NCT02185053 Alzheimer's Disease Phase 2 Completed - United States, Florida ... More >> CPC1 West Palm Beach, Florida, United States Less <<
NCT01677754 Alzheimer's Disease Phase 2 Completed - -
NCT00004807 Rett Syndrome Not Applicable Completed - -
NCT00006399 Alzheimer Disease Phase 2 Completed - United States, Vermont ... More >> Clinical Neuroscience Research Unit, University of Vermont Burlington, Vermont, United States, 05401 Less <<
NCT02918266 Healthy Volunteers Phase 1 Terminated(Terminated prematur... More >>ely due to indication change.) Less << - United States, California ... More >> Glendale, California, United States Less <<
NCT00234637 Alzheimer's Disease Phase 4 Completed - France ... More >> Département de Gérontologie Clinique Limoges, Cedex, France, 87042 Less <<
NCT02337907 Alzheimer Disease Phase 2 Completed - -
NCT02570581 Healthy Phase 1 Completed - France ... More >> Center for Clinical Research - Archet 1 Hospital Nice Hospital Nice, France, 06200 Less <<
NCT01529619 Alzheimer's Disease Phase 4 Completed - Japan ... More >> Novartis Investigative Site Nagoya-city, Aichi, Japan, 467-8602 Novartis Investigative Site Fukuoka-city, Fukuoka, Japan, 814-0180 Novartis Investigative Site Miyoshi-city, Hiroshima, Japan, 728-0013 Novartis Investigative Site Ohtake, Hiroshima, Japan, 739-0696 Novartis Investigative Site Kita-gun, Kagawa, Japan, 761-0793 Novartis Investigative Site Kamakura-city, Kanagawa, Japan, 247-8533 Novartis Investigative Site Kawasaki-city, Kanagawa, Japan, 216-8511 Novartis Investigative Site Yokohama, Kanagawa, Japan, 241-0811 Novartis Investigative Site Koshi-city, Kumamoto, Japan, 861-1116 Novartis Investigative Site Kyoto-city, Kyoto, Japan, 600-8558 Novartis Investigative Site Kyoto, Japan, 606-0851 Less <<
NCT02703636 Mild to Moderate Alzheimer's D... More >>isease Less << Phase 4 Completed - Japan ... More >> Novartis Investigative Site Fukuoka-city, Fukuoka, Japan, 814-001 Novartis Investigative Site Fukuoka-city, Fukuoka, Japan, 814-0180 Novartis Investigative Site Aizuwakamatsu, Fukushima, Japan, 965-8585 Novartis Investigative Site Tsukuba-city, Ibaraki, Japan, 305-8576 Novartis Investigative Site Kita-gun, Kagawa, Japan, 761-0793 Novartis Investigative Site Sagamihara-city, Kanagawa, Japan, 252-5188 Novartis Investigative Site Kochi-city, Kochi, Japan, 780-0842 Novartis Investigative Site Kurashiki-city, Okayama, Japan, 710-0826 Novartis Investigative Site Osaka-city, Osaka, Japan, 543-8555 Novartis Investigative Site Suita-city, Osaka, Japan, 565 0871 Novartis Investigative Site Kasukabe-city, Saitama, Japan, 344-0036 Novartis Investigative Site Koshigaya-city, Saitama, Japan, 343-0032 Novartis Investigative Site Fuji-city, Shizuoka, Japan Novartis Investigative Site Bunkyo-ku, Tokyo, Japan, 113-8431 Novartis Investigative Site Hachioji-city, Tokyo, Japan, 193-0944 Novartis Investigative Site Shinjuku-ku, Tokyo, Japan, 160-0023 Novartis Investigative Site Niigata, Japan Novartis Investigative Site Okayama, Japan, 710-0813 Novartis Investigative Site Tokyo, Japan, 168-8535 Less <<
NCT00018278 Alzheimer Disease Phase 4 Completed - United States, California ... More >> Department of Veterans Affairs San Diego, California, United States, 92161 Less <<
NCT01450839 Healthy Phase 1 Completed - Japan ... More >> Kagoshima, Japan Less <<
NCT03184467 Alzheimer Disease Phase 2 Recruiting June 2019 Korea, Republic of ... More >> Hanyang University Guri Hospital Recruiting Guri-si, Gyunggi-do, Korea, Republic of, 11923 Contact: Seong-Ho Koh, MD, PhD.       ksh213@hanyang.ac.kr Less <<
NCT02337907 - Completed - -
NCT00519298 Healthy Adult Phase 1 Completed - France ... More >> Rouffach, France, 68250 Less <<
NCT03221894 - Recruiting September 2017 China ... More >> Dongzhimen Hospital Recruiting Beijing, China Contact: Jing Shi, M.D.    86-10-84013132    shijing87@hotmail.com Less <<
NCT02007291 - Completed - -
NCT03025334 Parkinson Disease ... More >> Mild Cognitive Impairment Less << Not Applicable Recruiting December 2020 Canada, Manitoba ... More >> University of Manitoba Recruiting Winnipeg, Manitoba, Canada, R3E 0J9 Contact: Ji Hyun Ko, PhD    204-318-2566    ji.ko@umanitoba.ca Less <<
NCT02007291 - Completed - -
NCT00428090 - Completed - -
NCT01944436 - Completed - Canada, Ontario ... More >> Sunnybrook Health Sciences Centre Toronto, Ontario, Canada, M4N3M5 Less <<
NCT01028911 Alzheimer's Disease Phase 1 Terminated(This study terminat... More >>ed 27Apr2010 due to slow recruitment and the need to use the existing information to determine dosing for another study.) Less << - United States, Kansas ... More >> Pfizer Investigational Site Wichita, Kansas, United States, 67207 Pfizer Investigational Site Wichita, Kansas, United States, 67211 Less <<
NCT01527916 Alzheimer's Disease Phase 2 Completed - -
NCT00267163 Cognition Disorders Phase 4 Completed - United States, California ... More >> UCLA, The Semel Institute for Neuroscience and Human Behavior Los Angeles, California, United States, 90024 Less <<
NCT00428090 Alzheimer's Disease Phase 3 Completed - -
NCT01028911 - Terminated(This study terminat... More >>ed 27Apr2010 due to slow recruitment and the need to use the existing information to determine dosing for another study.) Less << - -
NCT00693004 Alzheimer's Disease Phase 2 Terminated - -
NCT01098383 Autism Phase 4 Unknown December 2017 Israel ... More >> Sheba Medical Center Recruiting Tel Hashomer, Ramat Gan, Israel, 52621 Contact: Shahar Shefer, Dr    +972-(0)54-4381594    DRShahar.Shefer@sheba.health.gov.il    Sub-Investigator: Maaian Millikovsky, BA Less <<
NCT03441516 Alzheimer's Disease Phase 4 Enrolling by invitation December 31, 2019 Korea, Republic of ... More >> Dong-A University Hospital Busan, Korea, Republic of Gyeongsang National University Hospital Busan, Korea, Republic of Inje University Busan Paik Hospital Busan, Korea, Republic of Inje University Haeundae Paik Hospital Busan, Korea, Republic of Pusan National University Yangsan Hospital Busan, Korea, Republic of Samsung Changwon Hospital Busan, Korea, Republic of Less <<
NCT00766363 Alzheimer's Disease ... More >> Central Nervous System Diseases Less << Phase 1 Completed - United States, California ... More >> Pacific Research Network, Inc. San Diego, California, United States, 92103 United States, Florida MD Clinical Hallandale Beach, Florida, United States, 33009 United States, New Jersey Comprehensive Clinical Research Berlin, New Jersey, United States, 08009 Global Medical Institutes, LLC Princeton, New Jersey, United States, 08540 Less <<
NCT00551161 - Completed - -
NCT01843556 Healthy Elderly Male Phase 1 Completed - Japan ... More >> Kagoshima, Japan Less <<
NCT02626572 Alzheimer's Disease Phase 2 Completed - -
NCT02769065 Alzheimer Disease ... More >> Healthy Volunteers Less << Phase 1 Terminated(Terminated prematur... More >>ely as data from cohort no longer needed due to indication change.) Less << - United States, California ... More >> Glendale, California, United States Less <<
NCT00551161 Alzheimer Disease Phase 4 Completed - United States, New York ... More >> The Litwin-Zucker Research Center Manhasset, New York, United States, 11030 Less <<
NCT00443014 Alzheimer Disease Phase 4 Completed - Norway ... More >> Arran Lulesami Centre Drag, Nordland, Norway, 8270 Less <<
NCT01940952 Alzheimer's Disease Phase 3 Unknown - Korea, Republic of ... More >> Samguns Medical Center Not yet recruiting Seoul, Korea, Republic of, 135-710 Contact: Enda Go, Clinical Research Coordinator    82-2-3410-2868    ed.ko@samsung.com    Principal Investigator: Duk L. Na, MD. PhD Less <<
NCT02187276 - Completed - -
NCT03011476 Parkinson Disease Phase 4 Recruiting December 30, 2018 Korea, Republic of ... More >> Kyung Hee Universtiy Hospital Recruiting Seoul, Korea, Republic of, 02447 Contact: Su Jin Hahn, BA    82-2-958-9579    khcri@khmc.or.kr    Contact: Kyung Wha Hahn, BA    82-2-958-9566    yynam@khmc.or.kr Less <<
NCT03454646 Alzheimer Disease ... More >> Cholinesterase Inhibitors Less << Phase 4 Not yet recruiting September 15, 2021 France ... More >> CHU d'Amiens Centre Mémoire Ressources Recherche Not yet recruiting Amiens, France, 80054 Contact: Agnès DEVENDEVILLE    03.22.66.82.40    devendeville.agnes@chu-amiens.fr    CHU d'Angers Centre Mémoire Ressources Recherche Angers, France, 49933 CHU de Bastia Centre Mémoire Ressources Recherche Not yet recruiting Bastia, France, 20604 Contact: Georges RETTALI    04.95.59.18.32    georges.retali@ch-bastia.fr    CHU de Besançon Centre Mémoire Ressources Recherche Besançon, France, 25030 CHU de Bordeaux - Service de Neurologie - Centre Mémoire Ressources Recherche - Not yet recruiting Bordeaux, France, 33076 Contact: Jean-François DARTIGUES    0557820116    jean-françois.dartigues@u-bordeaux.fr    CHRU Cavale Blanche Service de Gériatrie Brest, France, 29200 Service de Neuropsychologie Hôpital Neurologique Pierre Wertheimer Not yet recruiting Bron, France, 69677 Contact: Hélène MOLLION    04.72.35.71.79    helene.mollion@chu-lyon.fr    CHU Côte de Nacre Service de neurologie et CMRR Caen, France, 14033 CHU de Clermont Ferrand Centre Mémoire Ressources Recherche Clermont-Ferrand, France, 63000 Hôpital Pasteur Service de Neurologie Colmar, France, 68000 CHU de Dijon- CMRR Not yet recruiting Dijon, France, 21679 Contact: Yannick BEJOT    03.80.29.58.03    yannick.bejot@chu-dijon.fr    Chu de Grenoble CMRR, Neurologie Not yet recruiting Grenoble, France, 38043 Contact: Olivier MOREAUD    04 76 76 57 90    omoreaud@chu-grenoble.fr    Hôpital Roger Salengro CMRR Lille, France, 59037 CHU Limoges Service de neurologie et CMRR Not yet recruiting Limoges, France, 87000 Contact: Leslie CARTZ-PIVER    05.55.43.12.15    Lcp.coglim@gmail.com    AP-HM Marseille, France CHU Montpellier Hôpital Gui de Chauliac CMRR Not yet recruiting Montpellier, France, 34295 Contact: Audrey GABOREAU DE LOUSTAL    04.67.33.60.29    a-gabelle@chu-montpellier.fr    CHU de Nantes Clinique Neurologique Hôpital GR Laennec Not yet recruiting Nantes, France, 44093 Contact: Claire BOUTOLEAU    02.40.16.54.22    claire.boutoleaubretonniere@chu-nantes.fr    Institut Claude Pompidou Centre Mémoire de Ressources et de Recherche Not yet recruiting Nice, France, 06100 Contact: Renaud David    04.92.03.47.70    claire.paquet@inserm.fr    APHP Hôpital Broca Not yet recruiting Paris, France, 75013 Contact: Olivier HANON    01.44.08.35.03    olivier.hanon@brc.aphp.fr    Hôpital Universitaire de la Pitié Salpêtrière Pavillon François Lhermitte Not yet recruiting Paris, France, 75013 Contact: Stéphane EPELBAUM    01.42.16.75.22    stephane.epelbaum@psl.aphp.fr    APHP Groupe Hospitalier Saint Louis Lariboisière Fernand Widal CMRR Not yet recruiting Paris, France, 75475 Contact: Claire PAQUET    01.40.05.49.54    claire.paquet@inserm.fr    CHU La Milétrie Pôle de Gériatrie Not yet recruiting Poitiers, France, 86021 Contact: Marc PACCALIN    05.49.44.44.27    m.paccalin@chu-poitiers.fr    CHU Reims Hôpital Maison Blanche Court Séjour Gériatrique Not yet recruiting Reims, France, 51092 Contact: Jean-Luc NOVELLA    03.26.78.44.10    jl.novella@chu-reims.fr    CHU de Rennes - Hôpital Pontchaillou / Service de Neurologie Not yet recruiting Rennes, France, 35033 Contact: Serge BELLIARD    02.99.87.30.26    serge.belliard@chu-rennes.fr    CHU de Rouen Hôpital Charles Nicolle Service Neurologie Not yet recruiting Rouen, France, 76031 Contact: David Wallon    06.08.97.29.59    david.wallon@chu-rouen.fr    Chu de Saint-Etienne, CMRR Not yet recruiting Saint-Étienne, France, 42055 Contact: Isabelle ROUCH    04.77.12.73.98    isabelle.rouch@chu-st-etienne.fr    Chu de Strasbourg Hôpital Ka Robertsau Pôle de Gériatrie - CMRR Not yet recruiting Strasbourg, France, 67200 Contact: Frédéric BLANC    03.88.12.86.38    frederic.blanc@chru-strasbourg.fr    Centre de Recherche Clinique du Gérontopôle Cité de la Santé Toulouse, France CHRU de Bretonneau Unité de gérontopsychiatrie Not yet recruiting Tours, France, 37000 Contact: Thomas DESMIDT    06.68.07.97.06    t.desmidt@chu-tours.fr    CHU Nancy Service de Gériatrie-CMRR Not yet recruiting Vandoeuvre les nancy, France, 54511 Contact: Thérèse RIVASSEAU JONVAUX    03.83.15.35.71    t.jonveaux@chu-nancy.fr    Hospice Civil de Lyon Hôpital des Charpennes Not yet recruiting Villeurbanne, France, 69100 Contact: Pierre KROLAK SALMON    04.72.43.20.50    pierre.krolak-salmon@chu-lyon.fr Less <<
NCT00766363 - Completed - -
NCT00645190 Alzheimer Disease Phase 3 Completed - -
NCT02860065 Alzheimer's Disease Phase 2 Withdrawn June 30, 2017 United States, Michigan ... More >> Henry Ford Health System--West Bloomfield Hospital West Bloomfield Township, Michigan, United States, 48322 Less <<
NCT00043589 Memory Disorders Not Applicable Completed - United States, California ... More >> Aging Clinical Research Center, VA Palo Alto Health Care System Palo Alto, California, United States, 94305 Less <<
NCT00031018 Memory Disorders ... More >> Alzheimer's Disease Less << Phase 2 Unknown - United States, Texas ... More >> University of Texas - Houston, Gerontology Center of the UTMSI Houston, Texas, United States, 77030 Less <<
NCT01362686 Dementia Alzh... More >>eimer's Disease Less << Not Applicable Terminated(Low study accrual c... More >>aused the study to be ended early.) Less << - United States, Indiana ... More >> Touchpoint Fishers, Indiana, United States, 46037 Methodist Center for Geriatric Medicine Indianapolis, Indiana, United States, 46202 University Clinical Neurology Indianapolis, Indiana, United States, 46202 Wishard Health Services Indianapolis, Indiana, United States, 46202 St. Vincent Center for Healthy Aging Indianapolis, Indiana, United States, 46260 Less <<
NCT00062972 Multiple Sclerosis Phase 3 Withdrawn(Study terminated/wit... More >>hdrawn) Less << - United States, New York ... More >> University Hospital and Medical Center Stony Brook, New York, United States, 11794-8121 Less <<
NCT01362686 - Terminated(Low study accrual c... More >>aused the study to be ended early.) Less << - -
NCT00602680 Alzheimer's Disease Phase 2 Terminated(Insufficient expect... More >>ed benefit risk) Less << - France ... More >> Sanofi-Aventis Administrative Office Paris, France Less <<
NCT00139373 Supranuclear Palsy, Progressiv... More >>e Less << Phase 2 Unknown - France ... More >> Centre d'Investigation Clinique-HÔPITAL PITIÉ-SALPETRIERE Recruiting Paris, France, 75013 Contact: Marie-Laure Welter, MD    33-42161950    marie-laure.welter@psl.aphp.fr    Contact: Bertrand Gaymard, MD, PhD    33-142162218    gaymard@ccr.jussieu.fr    Principal Investigator: Bertrand Gaymard, MD, PhD Less <<
NCT00948909 Alzheimer's Disease Phase 2 Completed - United States, California ... More >> Site Reference ID/Investigator# 19904 Fresno, California, United States, 93720 United States, Florida Site Reference ID/Investigator# 23025 West Palm Beach, Florida, United States, 33407 United States, Indiana Site Reference ID/Investigator# 19905 Indianapolis, Indiana, United States, 46260 Bulgaria Site Reference ID/Investigator# 22944 Pleven, Bulgaria, 5800 Site Reference ID/Investigator# 22942 Plovdiv, Bulgaria, 4000 Site Reference ID/Investigator# 22945 Sofia, Bulgaria, 1113 Site Reference ID/Investigator# 22946 Sofia, Bulgaria, 1431 Czech Republic Site Reference ID/Investigator# 20276 Litomerice, Czech Republic, 412 01 Site Reference ID/Investigator# 20273 Plzen, Czech Republic, 301 36 Site Reference ID/Investigator# 20274 Prague 10, Czech Republic, 100 00 Site Reference ID/Investigator# 20272 Prague 2, Czech Republic, 120 00 Site Reference ID/Investigator# 20701 Prague 5, Czech Republic, 15006 Slovakia Site Reference ID/Investigator# 23625 Bratislava, Slovakia, 82606 Site Reference ID/Investigator# 23624 Bratislava, Slovakia Site Reference ID/Investigator# 23622 Michalovce, Slovakia, 07101 Site Reference ID/Investigator# 23942 Rimavska Sobota, Slovakia, 979 12 South Africa Site Reference ID/Investigator# 20267 Belville, South Africa, 7530 Site Reference ID/Investigator# 20266 Cape Town, South Africa, 7500 Site Reference ID/Investigator# 20261 Durban, South Africa, 4001 Site Reference ID/Investigator# 21682 George, South Africa, 6529 Site Reference ID/Investigator# 20265 Johannesburg, South Africa, 2196 Site Reference ID/Investigator# 20271 Port Elizabeth, South Africa, 6001 Site Reference ID/Investigator# 20263 Richards Bay, South Africa, 3900 United Kingdom Site Reference ID/Investigator# 20187 Blackburn, United Kingdom, BB2 3HH Site Reference ID/Investigator# 20183 Bradford, United Kingdom, BD3 0DQ Site Reference ID/Investigator# 20191 Crowborough, United Kingdom, TN6 1HB Site Reference ID/Investigator# 20184 Glasgow, United Kingdom, G20 0XA Site Reference ID/Investigator# 20190 London, United Kingdom, TW8 8DS Site Reference ID/Investigator# 20192 Southampton, United Kingdom, SO30 3JB Less <<
NCT00042172 Cognition Disorders ... More >> Alzheimer Disease Less << Phase 4 Completed - United States, Iowa ... More >> University of Iowa Department of Psychiatry Iowa City, Iowa, United States, 52242 Less <<
NCT00142324 Alzheimer's Disease Phase 4 Unknown - United Kingdom ... More >> Queen Elizabeth Psychiatric Hospital Birmingham, United Kingdom, B15 2QZ Department of Psychiatry for the Elderly, Leicester General Hospital Leicester, United Kingdom, LE5 4PW Institute of Psychiatry, King's College, London London, United Kingdom, SE5 8AF Old Age Psychiatry, Wythenshawe Hospital, Manchester Manchester, United Kingdom, M23 9LT Institute for Ageing and Health, Newcastle General Hospital, Newcastle Newcastle upon Tyne, United Kingdom, NE4 6BE Department of Psychiatry, Warneford Hospital, Oxford Oxford, United Kingdom, OX3 7JX MARC, Moorgreen Hospital, Southamptom Southampton, United Kingdom, S030 3JB Department of Old Age Psychiatry, Victoria Hospital, Swindon Swindon, United Kingdom, SN1 4HZ Less <<
NCT02406261 Healthy Phase 1 Completed - United States, Florida ... More >> Covance Inc Daytona Beach, Florida, United States, 32117 United States, Texas Covance Inc Dallas, Texas, United States, 75247 Less <<
NCT02035982 Alzheimer's Disease ... More >> Dementia Less << Phase 3 Completed - Canada, Ontario ... More >> North York General Hospital Toronto, Ontario, Canada, M2K1E1 Sunnybrook Health Sciences Centre Toronto, Ontario, Canada, M4N 3M5 Less <<
NCT00315367 Relapsing-Remitting Multiple S... More >>clerosis Less << Phase 4 Completed - United States, Wisconsin ... More >> Medical College of Wisconsin Milwaukee, Wisconsin, United States, 53226 Less <<
NCT01903824 Cognitive Impairment Phase 1 Completed - Netherlands ... More >> Teva Investigational Site 38051 Leiden, Netherlands Less <<
NCT02453932 Vascular Dementia Phase 3 Completed - China, Beijing ... More >> Dongzhimen Hospital,Beijing University of Chinese Medicine Beijing, Beijing, China, 100700 Less <<
NCT01018875 Alzheimer's Disease Phase 2 Completed - Russian Federation ... More >> Site Reference ID/Investigator# 22687 Kazan, Russian Federation, 420012 Site Reference ID/Investigator# 22636 Moscow, Russian Federation, 115522 Site Reference ID/Investigator# 23702 Moscow, Russian Federation, 123995 Site Reference ID/Investigator# 22689 Saratov, Russian Federation, 410060 Site Reference ID/Investigator# 22635 St. Petersburg, Russian Federation, 190005 Site Reference ID/Investigator# 22633 St. Petersburg, Russian Federation, 190103 Site Reference ID/Investigator# 22637 St. Petersburg, Russian Federation, 190121 Site Reference ID/Investigator# 22632 St. Petersburg, Russian Federation, 192019 Site Reference ID/Investigator# 22634 St. Petersburg, Russian Federation, 192019 Site Reference ID/Investigator# 24563 St. Petersburg, Russian Federation, 194044 Ukraine Site Reference ID/Investigator# 22630 Dnipropetrovs'k, Ukraine, 49027 Site Reference ID/Investigator# 22625 Donetsk, Ukraine Site Reference ID/Investigator# 22624 Glevakha, Ukraine, 08631 Site Reference ID/Investigator# 22629 Kharkiv, Ukraine, 61168 Site Reference ID/Investigator# 24565 Kherson, Ukraine, 73488 Site Reference ID/Investigator# 24566 Kiev, Ukraine, 04112 Site Reference ID/Investigator# 22622 Kiev, Ukraine, 04114 Site Reference ID/Investigator# 22623 Kiev, Ukraine, 05113 Site Reference ID/Investigator# 22628 Lugansk, Ukraine, 91045 Site Reference ID/Investigator# 43143 Odessa, Ukraine, 65006 Site Reference ID/Investigator# 22627 Poltava, Ukraine, 36006 Less <<
NCT01137526 Alzheimer's Disease Phase 2 Completed - Russian Federation ... More >> Site Reference ID/Investigator# 40834 Ekaterinburg, Russian Federation, 620030 Site Reference ID/Investigator# 36304 Kazan, Russian Federation, 420097 Site Reference ID/Investigator# 36306 Kirov, Russian Federation, 610014 Site Reference ID/Investigator# 37944 Moscow, Russian Federation, 119048 Site Reference ID/Investigator# 26909 Saratov, Russian Federation, 410060 Site Reference ID/Investigator# 26904 St. Petersburg, Russian Federation, 190005 Site Reference ID/Investigator# 26902 St. Petersburg, Russian Federation, 190103 Site Reference ID/Investigator# 36305 St. Petersburg, Russian Federation, 198510 Site Reference ID/Investigator# 38383 Yaroslavl, Russian Federation, 150030 South Africa Site Reference ID/Investigator# 45584 Belville, South Africa, 7530 Site Reference ID/Investigator# 47102 George, South Africa, 6529 Site Reference ID/Investigator# 45583 Johannesburg, South Africa, 2196 Ukraine Site Reference ID/Investigator# 39855 Donetsk, Ukraine, 83003 Site Reference ID/Investigator# 26914 Kharkiv, Ukraine, 61177 Site Reference ID/Investigator# 26912 Kiev, Ukraine, 04114 Site Reference ID/Investigator# 40484 Lviv, Ukraine, 79010 Site Reference ID/Investigator# 27002 Poltava, Ukraine, 36006 Site Reference ID/Investigator# 39856 Poltava, Ukraine, 36024 Site Reference ID/Investigator# 40482 Simferopil, Ukraine, 95006 Site Reference ID/Investigator# 40483 Ternopil, Ukraine, 46020 Site Reference ID/Investigator# 35660 Vinnytsia, Ukraine, 21005 United Kingdom Site Reference ID/Investigator# 36327 Bath, United Kingdom, BA1 3NG Site Reference ID/Investigator# 35657 Blackburn, United Kingdom, BB2 3HH Site Reference ID/Investigator# 36330 Crowborough, United Kingdom, TN6 1HB Site Reference ID/Investigator# 36326 Glasgow, United Kingdom, G20 0XA Site Reference ID/Investigator# 44123 Ivybridge, Devon, United Kingdom, PL21 9AB Site Reference ID/Investigator# 35658 London, United Kingdom, TW8 8DS Site Reference ID/Investigator# 35902 Northampton, United Kingdom, NN5 6UD Site Reference ID/Investigator# 36328 Oxford, United Kingdom, OX3 9DU Site Reference ID/Investigator# 36329 Peterborough, United Kingdom, PE2 7JU Less <<
NCT03569579 Central Nervous System Disease... More >>s Less << Phase 1 Completed - Korea, Republic of ... More >> Chonbuk National University Hospital Jeonju, Korea, Republic of Less <<
NCT01409564 Alzheimer's Dementia Phase 4 Completed - Korea, Republic of ... More >> SMG-SNU Boramae Medical Center Seoul, Korea, Republic of, 156-707 Less <<
NCT00000173 Alzheimer Disease Phase 3 Completed - -
NCT03151382 Alzheimer Disease ... More >> Cognitive Function Less << Phase 4 Not yet recruiting June 30, 2018 -
NCT01409564 - Completed - -
NCT03283059 Alzheimer Disease Phase 3 Recruiting February 16, 2020 China, Shanghai ... More >> Shanghai Mental Health Center Recruiting Shanghai, Shanghai, China, 200030 Contact: Shifu Xiao, M.D., Ph.D.    +86 21 64387250 ext 73441    xiaoshifu@msn.com    Contact: Tao Wang, M.D., Ph.D.    +86 18017311279    wtshhwy@163.com Less <<
NCT02648906 Alzheimer Disease Phase 4 Unknown - Korea, Republic of ... More >> Seoul National University Bundang Hospital Recruiting Sungnam, Korea, Republic of Less <<
NCT00015132 Cocaine-Related Disorders Phase 2 Completed - United States, Ohio ... More >> Cincinnati MDRU Cincinnati, Ohio, United States, 45220 Less <<
NCT00967707 Post-traumatic Neuropathic Pai... More >>n Less << Phase 2 Completed - Sweden ... More >> Multidisciplinary Pain Centre, Uppsala University Hospital Uppsala, Sweden, 75185 Less <<
NCT00206947 Schizophrenia Phase 2 Terminated(No more funding) - Denmark ... More >> Center for Neuropsychiatric Schizophrenia Research, University of Copenhagen, Dept. F, Bispebjerg Hospital Copenhagen NV, Denmark, DK-2400 Dept. of Psychiatry O, Rigshospitalet, Blegdamsvej 9 Copenhagen, Denmark, DK-2100 Psychiatric Center, Glostrup Glostrup, Denmark, DK-2600 Danish Research Center for Magnetic Resonance Imaging, Hvidovre Hospital Hvidovre, Denmark, DK-2650 Less <<
NCT03090516 Alzheimer's Phase 2 Phase 3 Recruiting March 10, 2018 China, Jiangsu ... More >> Ting Wu Recruiting Nanjing, Jiangsu, China, 210000 Contact: Ting Wu, professor    18851122018    wuting80000@126.com    Contact: Wanrong Zhang, master    15851875395    zwr10010533@163.com Less <<
NCT00895895 Alzheimer Disease Phase 2 Terminated(See termination rea... More >>son in detailed description.) Less << - -
NCT01772095 - Completed - Greece ... More >> Aiginition University Hospital Athens, Greece Less <<
NCT02573519 Diabetic Autonomic Neuropathy ... More >> Gastrointestinal Motility Disorder Diabetes Mellitus Change of Transit or Circulation Less << Not Applicable Recruiting August 2019 Denmark ... More >> Department of Hematology and Gastroenterology, Aarhus University Hospital Recruiting Aarhus, Denmark, 8000 Contact: Mette Winther Andersen    +45 22635197    meteader@rm.dk    Contact: Klaus Krogh, Professor    +45 23385937    klaukrog@rm.dk    Sub-Investigator: Anne-Mette Haase, P.hD.          Sub-Investigator: Lotte Fynne, P.hD. Less <<
NCT03030105 Alzheimer Disease Phase 1 Completed - United States, Texas ... More >> ICON Early Phase Services, LLC Austin, Texas, United States, 78209 Less <<
NCT00480870 Alzheimer Disease ... More >> Sleep Apnea, Obstructive Less << Phase 4 Completed - Brazil ... More >> Instituto do Sono Sao Paulo, Brazil, 04020-060 Less <<
NCT00151398 Alzheimer Disease Phase 2 Completed - -
NCT00104273 Dementia Alzh... More >>eimer's Disease Less << Phase 2 Completed - -
NCT01379001 Cholinergic Function Not Applicable Completed - -
NCT00165724 Alzheimer's Disease PHASE4 COMPLETED 2006-12-31 Bobath Memorial Hospital, Bund... More >>ang, Korea, Republic of|Bundang Seoul National University Hospital, Bundang, Korea, Republic of|Changwon Fatima Hospital, Changwon, Korea, Republic of|Yeungnam University Hospital, Daegu, Korea, Republic of|Inha University Hospital, Incheon, Korea, Republic of|Catholic University Hospital, Seoul, Korea, Republic of|Eulji University Hospital, Seoul, Korea, Republic of Less <<
NCT00829374 Alzheimer's Disease Phase 3 Completed - -
NCT01712074 Alzheimer's Disease Phase 2 Terminated(The study was termi... More >>nated October 23, 2015 as pre-specified, interim analysis futility criteria were met. The termination was not due to safety concerns.) Less << - -
NCT00777608 - Completed - -
NCT01039701 Mild to Moderate Alzheimer's D... More >>isease Less << Phase 2 Completed - Czech Republic ... More >> Research Site Litomerice, Czech Republic Research Site Praha 10 - Strasnice, Czech Republic Research Site Praha 10, Czech Republic Research Site Praha 6, Czech Republic Hungary Research Site Debrecen, Hungary Research Site Esztergom, Hungary Research Site Miskolc, Hungary Research Site Nagykallo, Hungary Research Site Nyiregyhaza, Hungary Research Site Szeged, Hungary Slovakia Research Site Bratislava, Slovakia Research Site Roznava, Slovakia Research Site Zlate Moravce, Slovakia Less <<
NCT00777608 Alzheimer's Disease Phase 1 Completed - -
NCT00586196 Delirium Phase 2 Completed - United States, Massachusetts ... More >> Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Less <<
NCT00895895 - Terminated(See termination rea... More >>son in detailed description.) Less << - -
NCT00586196 - Completed - -
NCT00384423 Alzheimer's Disease Phase 2 Completed - United States, California ... More >> California Clinical Trials Medical Group, Inc Paramount, California, United States, 90723 Southwest CLinical Research Rancho Mirage, California, United States, 94109 Pacific Research Network, Inc San Diego, California, United States, 92103 San Francisco Clinical Research Center San Francisco, California, United States, 94109 Torrance Clinical Research Torrance, California, United States, 90505 United States, Connecticut Research Center for Clinical Studies Darien, Connecticut, United States, 06820 United States, Florida Miami Jewish Home and Hospital for the Aged Miami, Florida, United States, 33137 Berma Research Plantation, Florida, United States, 33317 Meridien Research St Petersburg, Florida, United States, 33709 Comprehensive NeuroScience, Inc St. Petersburg, Florida, United States, 33702 United States, Georgia Atlanta Center for Medical Research Atlanta, Georgia, United States, 30308 United States, Louisiana J. Gary Booker, MD Shreveport, Louisiana, United States, 71104 United States, Massachusetts Neuroscience Research of the Berkshires Pittsfield, Massachusetts, United States, 01201 United States, Ohio Neurology Specialists Dayton, Ohio, United States, 45408 United States, Oklahoma Saint Johns Office Building Tulsa, Oklahoma, United States, 74104 United States, Pennsylvania The Clinical Trial Center, LLC Jenkintown, Pennsylvania, United States, 19046 United States, South Carolina Alliance for Neuro Research, LLC Greenville, South Carolina, United States, 29615 Less <<
NCT00672945 Alzheimer's Disease Phase 2 Terminated - -
NCT02055703 Healthy Subjects Phase 1 Completed - United States, Texas ... More >> WCT Early Development San Antonio, Texas, United States, 78217 Less <<
NCT01712074 - Terminated(The study was termi... More >>nated October 23, 2015 as pre-specified, interim analysis futility criteria were met. The termination was not due to safety concerns.) Less << - -
NCT00842816 Alzheimer's Disease Phase 2 Completed - -
NCT00884507 Alzheimer's Disease Phase 2 Completed - -
NCT00467766 Alzheimer Disease ... More >> Caregivers Less << Not Applicable Completed - United States, New York ... More >> Aging and Dementia Research Center, Silberstein Institute, NYU School of Medicine New York, New York, United States, 10016 Australia, New South Wales Prince of Wales Hospital Randwick, New South Wales, Australia, 2031 United Kingdom University of Manchester, Division of Psychiatry Manchester, United Kingdom, M23 9LT Less <<
NCT01406145 Alzheimer's Disease Phase 1 Completed - United States, California ... More >> Pacific Research Network, Inc. San Diego, California, United States, 92103 United States, Florida MD Clinical Hallandale Beach, Florida, United States, 33009 Less <<
NCT02695004 Alzheimer's Disease Phase 1 Unknown December 2017 Korea, Republic of ... More >> Seoul National Univ. Bundang Hospital Recruiting Seongnam, Korea, Republic of Contact: JY Chung       jychung@snubh.org Less <<
NCT02262975 - Completed - China ... More >> Beijing, China Gangwon, China Hong Kong, China Nanjing, China Shaanxi, China Shanghai, China Korea, Republic of Busan, Korea, Republic of Daegu, Korea, Republic of Daejeon, Korea, Republic of Gyeonggi, Korea, Republic of Incheon, Korea, Republic of Jeonju, Korea, Republic of Kangwon, Korea, Republic of Seongnam, Korea, Republic of Seoul, Korea, Republic of Philippines Manila, Philippines Singapore Singapore, Singapore Taiwan Bangkok, Taiwan Changhua, Taiwan Kaohsiung, Taiwan New Taipei, Taiwan Taichung, Taiwan Tainan, Taiwan Taipei, Taiwan Thailand Bangkok, Thailand Shanghai, Thailand Less <<
NCT00348192 Alzheimer's Disease Phase 2 Completed - Austria ... More >> GSK Investigational Site Hall in Tirol, Austria, A-6060 GSK Investigational Site Vienna, Austria, A-1130 GSK Investigational Site Vienna, Austria, A-1220 Bulgaria GSK Investigational Site Sofia, Bulgaria, 1113 GSK Investigational Site Sofia, Bulgaria, 1431 GSK Investigational Site Varna, Bulgaria, 9010 Chile GSK Investigational Site Providencia / Santiago, Región Metro De Santiago, Chile, 7500710 GSK Investigational Site Santiago, Región Metro De Santiago, Chile, 7560356 GSK Investigational Site Valparaiso, Valparaíso, Chile, 2352499 Estonia GSK Investigational Site Tallinn, Estonia, 10617 GSK Investigational Site Tartu, Estonia, 51014 Germany GSK Investigational Site Ostfildern, Baden-Wuerttemberg, Germany, 73760 GSK Investigational Site Huettenberg, Hessen, Germany, 35625 GSK Investigational Site Achim, Niedersachsen, Germany, 28832 GSK Investigational Site Baesweiler, Nordrhein-Westfalen, Germany, 52499 GSK Investigational Site Hattingen, Nordrhein-Westfalen, Germany, 45525 Russian Federation GSK Investigational Site Moscow, Russian Federation, 115552 GSK Investigational Site Moscow, Russian Federation, 117049 GSK Investigational Site St. Petersburg, Russian Federation, 197022 GSK Investigational Site St.-Petersburg, Russian Federation, 198103 Slovakia GSK Investigational Site Bratislava, Slovakia, 811 01 GSK Investigational Site Bratislava, Slovakia, 826 06 GSK Investigational Site Bratislava, Slovakia, 831 03 United Kingdom GSK Investigational Site Bradford, United Kingdom, BD7 1HR GSK Investigational Site Swindon, United Kingdom, SN1 4HZ GSK Investigational Site West of Scotland Science Park, Glasgow, United Kingdom, G20 0XA Less <<
NCT00177671 Depression De... More >>mentia Less << Phase 4 Completed - United States, Pennsylvania ... More >> University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, United States, 15213 Less <<
NCT00182884 Postoperative Complications ... More >> Delirium Less << Phase 4 Completed - United States, Indiana ... More >> Methodist Hospital, Clarian Health Partners Indianapolis, Indiana, United States, 46202 Less <<
NCT00177671 - Completed - -
NCT00482001 Mental Health ... More >> Geriatrics Less << Phase 4 Completed - Canada, Ontario ... More >> Lakehead University Thunder Bay, Ontario, Canada, P7B 5E1 Sunnybrook Health Sciences Centre Toronto, Ontario, Canada, M4N 3M5 Less <<
NCT01401582 Dementia Not Applicable Active, not recruiting March 2018 Germany ... More >> Institute for Community Medicine Greifswald, Mecklenburg- Western Pommerania, Germany, 17489 Less <<
NCT02860338 - Completed - -
NCT01401582 - Active, not recruiting - -
NCT00291421 - Completed - -
NCT00548145 - Terminated - -
NCT02462291 - Completed - -
NCT02696512 Brain Injury Phase 1 Phase 2 Unknown April 2017 United States, New Jersey ... More >> International Brain Research Foundation Recruiting Edison, New Jersey, United States, 08837 Contact: Philip Defina, PhD    732-494-7600    pdefina@ibrfinc.org    Principal Investigator: Philip Defina, PhD Less <<
NCT02462291 Alzheimer Disease ... More >> Behavioral Disorders Cognitive Impairment Less << Not Applicable Completed - Italy ... More >> Mons. Mazzali Foundation Mantua Italy, Mantua, Italy, 46100 Less <<
NCT00548145 Alzheimer Disease ... More >> Hypercholesterolemia Less << Not Applicable Terminated - Japan ... More >> Osaka University Hospital Suita, Osaka, Japan, 565-0871 Less <<
NCT02374567 Dementia Depr... More >>ession Schizophrenia Psychosomatic Disorders Anxiety Disorders Less << Phase 3 Terminated - Germany ... More >> Bezirkskrankenhaus Augsburg Augsburg, Germany Krankenhaus Hedwigshöhe Berlin, Germany Hannover Medical School Hannover, Germany, 30625 Asklepios Fachklinikum Lübben Lübben, Germany Asklepios Fachklinikum Teupitz Teupitz, Germany Less <<
NCT01852110 - Terminated(Stage 1 interim ana... More >>lysis of efficacy met the criteria for early trial termination (futility). The trial was terminated at Stage 1; did not proceed to Stage 2.) Less << - -
NCT02623764 - Active, not recruiting November 2019 -
NCT01249196 Alzheimer's Disease Phase 3 Completed - Korea, Republic of ... More >> SKChemicals invetigational site Seoul, Korea, Republic of Less <<
NCT01852110 Alzheimer's Disease Phase 2 Terminated(Stage 1 interim ana... More >>lysis of efficacy met the criteria for early trial termination (futility). The trial was terminated at Stage 1; did not proceed to Stage 2.) Less << - -
NCT00880412 Alzheimer's Disease Phase 2 Completed - France ... More >> Hôpital Privé Les Magnolias Ballainvilliers, France, 91160 Cabinet Médical Bergerac, France, 24100 Fleyriat Hospital Bourg en Bresse, France, 01012 Cabinet Médical Dijon, France, 21000 Charles Foix Hospital Ivry sur Seine, France, 94026 Cabinet Médical La Seyne sur Mer, France, 83500 Roger Salengro Hospital Lille, France, 59037 Dupuytren Hospital Limoges, France, 87042 Clinique Léopold Bellan Magnanville, France, 78200 Cabinet Médical Montpellier, France, 34070 Cabinet Médical 2 Montpellier, France, 34080 CHU Nantes Hôpital Laennec Nantes, France, 44093 Cabinet Médical 2 Nice, France, 06000 Cabinet Médical Nice, France, 06000 CHU Cochin Broca Paris, France, 75013 Cabinet Médical Rambouillet, France, 78120 CHU Rennes Rennes, France, 35033 Cabinet Médical Rodez, France, 12000 Cabinet Médical Rueil Malmaison, France, 92500 Cabinet Médical Saint Brieuc, France, 22000 Cabinet Médical Toulon, France, 83000 Purpan-Casselardit Hospital - University of Toulouse Toulouse, France, 31059 Less <<
NCT02670161 Brain Tumors ... More >>Epilepsy Migraine Mild Cognitive Impairment Concussion Multiple Sclerosis Neuropathy Parkinson's Restless Legs Syndrome Stroke Less << Phase 4 Enrolling by invitation April 2020 -
NCT00702780 - Completed - -
NCT01696591 - Unknown September 2013 Korea, Republic of ... More >> Samsung Medical Center Recruiting Seoul, Korea, Republic of, 135-710 Contact: Duk L. Na, MD, PhD    +82-2-3410-3594    dukna@naver.com Less <<
NCT03352739 Alzheimer Disease Not Applicable Recruiting December 1, 2020 China ... More >> Xuanwu Hospital, Capital Medical University. Recruiting Beijing, China, 100053 Contact: Peng-Hu Wei, M.D.    +86-18601986863 Less <<
NCT03565809 - Enrolling by invitation December 2018 France ... More >> University Hospital Toulouse, France, 31000 Less <<
NCT00348140 Alzheimer's Disease Phase 3 Completed - -
NCT02586909 Alzheimer's Disease Phase 3 Terminated(Intepirdine did not... More >> meet its primary efficacy endpoints in lead-in study RVT-101-3001.) Less << - -
NCT02549196 Dementia of Alzheimer's Type Phase 2 Completed - United States, Florida ... More >> Quantum Laboratories Deerfield Beach, Florida, United States, 33064 Less <<
NCT00348140 - Completed - -
NCT00702780 Alzheimer's Disease Not Applicable Completed - Korea, Republic of ... More >> Kangwon National University Hospital Chuncheon, Korea, Republic of Seoul National University Bundang Hospital Seongnam, Korea, Republic of Seoul National University Hospital Seoul, Korea, Republic of, 110-744 Konkuk University Hospital Seoul, Korea, Republic of Less <<
NCT00951834 Alzheimer's Disease Phase 2 Phase 3 Completed - Germany ... More >> Charite University Medicine Berlin Berlin, Germany, 10117 Charité Universitätsmedizin Berlin Klinik für Psychiatrie und Psychotherapie Berlin, Germany, 10117 Klinik für Neurologie Ulm, Germany, 89081 Less <<
NCT02839642 Progressive Supranuclear Palsy... More >> (PSP) Less << Phase 3 Recruiting November 2019 France ... More >> Service de Neurologie et Pathologie du Mouvement Hôpital de La Timone Recruiting Marseille Cedex 5, France, 13385 Contact: Alexandre EUSEBIO, Dr    04.91.38.43.33 ext +33    alexandre.eusebio@ap-hm.fr Less <<
NCT00165737 Dementia, Vascular PHASE3 COMPLETED 2025-06-06 Central Arkansas Research (CAR... More >>E), Hot Springs, Arkansas, 71913, United States|Comprehensive Neuroscience, St. Petersburg, Florida, 33702, United States|St. Francis Medical Center, Peoria, Illinois, 61637, United States|Neurological Associate of Albany PC, Albany, New York, 12208, United States|University of Texas Mental Sciences Institute, Houston, Texas, 77030, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.40mL

0.48mL

0.24mL

12.02mL

2.40mL

1.20mL

24.04mL

4.81mL

2.40mL

References

 

Historical Records

Categories