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CAS No. :	571203-78-6
Formula :	C₃₀H₃₁ClN₄O₄
M.W :	547.04
SMILES Code :	O=C1N(C2=CC=CC=C2OCC)C(C(N3CCN(C(COC4=CC=C(Cl)C=C4)=O)CC3)C)=NC5=C1C=CC=C5
MDL No. :	MFCD09837984
InChI Key :	BKQFRNYHFIQEKN-UHFFFAOYSA-N
Pubchem ID :	11214940

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

N27 cells	36~116 nM (erastin), 29~73 nM (RSL3)	24 hours	GNF-5837 significantly inhibits erastin- and RSL3-induced ferroptosis	Int J Mol Sci. 2022;23(24):16205.
HT-1080 cells	36~116 nM (erastin), 29~73 nM (RSL3)	24 hours	GNF-5837 significantly prevents ferroptosis	Int J Mol Sci. 2022;23(24):16205.
HT-22 cells	36~116 nM (erastin), 29~73 nM (RSL3)	24 hours	GNF-5837 significantly prevents ferroptosis	Int J Mol Sci. 2022;23(24):16205.
KYSE510 cells	50 μM and 100 μM	24 hours	Evaluate the effects of Erastin on cell viability and ATP levels, results showed Erastin decreased cell viability and ATP levels.	Anim Cells Syst (Seoul). 2024 May 11;28(1):237-250.
KYSE30 cells	50 μM and 100 μM	24 hours	Evaluate the effects of Erastin on cell viability and ATP levels, results showed Erastin decreased cell viability and ATP levels.	Anim Cells Syst (Seoul). 2024 May 11;28(1):237-250.
HT22 mouse hippocampal neuronal cells	0.8 μM	24 hours	To evaluate the protective effect of catechol estrogens against erastin/RSL3-induced ferroptosis. Results showed that four catechol estrogens (2-OH-E1, 2-OH-E2, 4-OH-E1, and 4-OH-E2) significantly inhibited erastin/RSL3-induced cell death and reduced the accumulation of NO, ROS, and lipid-ROS.	Sci Rep. 2024 Oct 14;14(1):23988.
Res1-6 and Hepa1-6 cells	5.0 μM	30 minutes	Detect lipid ROS levels, finding that Res1-6 cells showed significantly reduced lipid ROS levels induced by erastin	Cell Rep Med. 2024 Feb 20;5(2):101415.
KYSE510	50 μM, 100 μM	24 hours	To evaluate the effect of Erastin on KYSE510 cell proliferation, results showed that Erastin significantly inhibited cell proliferation and colony formation ability, decreased ATP levels and increased ROS production.	Anim Cells Syst (Seoul). 2024 May 11;28(1):237-250
KYSE30	50 μM, 100 μM	24 hours	To evaluate the effect of Erastin on KYSE30 cell proliferation, results showed that Erastin significantly inhibited cell proliferation and colony formation ability, decreased ATP levels and increased ROS production.	Anim Cells Syst (Seoul). 2024 May 11;28(1):237-250
KYSE510	50 μM, 100 μM	24 hours	Evaluate the effect of Erastin on the proliferation of KYSE510 cells. Results showed that Erastin significantly inhibited cell proliferation and colony formation ability, reduced ATP levels, and increased ROS production.	Anim Cells Syst (Seoul). 2024 May 11;28(1):237-250
KYSE30	50 μM, 100 μM	24 hours	Evaluate the effect of Erastin on the proliferation of KYSE30 cells. Results showed that Erastin significantly inhibited cell proliferation and colony formation ability, reduced ATP levels, and increased ROS production.	Anim Cells Syst (Seoul). 2024 May 11;28(1):237-250
NCI-H660	1.25, 2.5, 5, 10, 20 μM	72 h	To evaluate the effect of Erastin on prostate cancer cell growth, results showed that Erastin significantly reduced the viability of NCI-H660 cells.	Cancer Res. 2021 Mar 15;81(6):1583-1594.
LNCaP	1.25, 2.5, 5, 10, 20 μM	72 h	To evaluate the effect of Erastin on prostate cancer cell growth, results showed that Erastin significantly reduced the viability of LNCaP cells.	Cancer Res. 2021 Mar 15;81(6):1583-1594.
C4-2	1.25, 2.5, 5, 10, 20 μM	72 h	To evaluate the effect of Erastin on prostate cancer cell growth, results showed that Erastin significantly reduced the viability of C4-2 cells.	Cancer Res. 2021 Mar 15;81(6):1583-1594.
22Rv1	1.25, 2.5, 5, 10, 20 μM	72 h	To evaluate the effect of Erastin on prostate cancer cell growth, results showed that Erastin significantly reduced the viability of 22Rv1 cells.	Cancer Res. 2021 Mar 15;81(6):1583-1594.
ARCaP	1.25, 2.5, 5, 10, 20 μM	72 h	To evaluate the effect of Erastin on prostate cancer cell growth, results showed that Erastin significantly reduced the viability of ARCaP cells.	Cancer Res. 2021 Mar 15;81(6):1583-1594.
PC3	1.25, 2.5, 5, 10, 20 μM	72 h	To evaluate the effect of Erastin on prostate cancer cell growth, results showed that Erastin significantly reduced the viability of PC3 cells.	Cancer Res. 2021 Mar 15;81(6):1583-1594.
DU145	1.25, 2.5, 5, 10, 20 μM	72 h	To evaluate the effect of Erastin on prostate cancer cell growth, results showed that Erastin significantly reduced the viability of DU145 cells.	Cancer Res. 2021 Mar 15;81(6):1583-1594.
PM3	6 µM	24 h	Erastin enhanced ACSL4 expression and reduced GPX4, which was alleviated by Fer-1. However, exogenous overexpression of wild-type NF2 abrogated the changes induced by Erastin and Fer-1.	Neuro Oncol. 2021 Dec 1;23(12):2014-2027.
IOMM-Lee	6 µM	24 h	Erastin induced ACSL4 upregulation in NF2-silenced IOMM-Lee cells, which was alleviated by Fer-1.	Neuro Oncol. 2021 Dec 1;23(12):2014-2027.
CH157	6 µM	24 h	Erastin enhanced ACSL4 expression and reduced GPX4, which was alleviated by Fer-1. However, exogenous overexpression of wild-type NF2 abrogated the changes induced by Erastin and Fer-1.	Neuro Oncol. 2021 Dec 1;23(12):2014-2027.
G-361 melanoma cells	5 µM	24 h	To investigate the degradation of VDAC2/3 by Erastin, it was found that the protein levels of VDAC2/3 were significantly reduced after Erastin treatment, indicating that Erastin induced the degradation of VDAC2/3.	Nat Commun. 2020 Jan 23;11(1):433.
A375 melanoma cells	5 µM	24 h	To investigate the degradation of VDAC2/3 by Erastin, it was found that the fluorescence intensity of VDAC2/3 was significantly reduced after Erastin treatment, indicating that Erastin induced the degradation of VDAC2/3.	Nat Commun. 2020 Jan 23;11(1):433.
human HT1080 fibrosarcoma cells	2 μM	10-14 h	To study the effect of Erastin on HT1080 cells, results showed that Erastin induced ferroptosis.	Nat Commun. 2024 Oct 17;15(1):8971.
mouse embryonic fibroblast (MEF) cells	2 μM	8-12 h	To study the effect of Erastin on MEF cells, results showed that Erastin induced ferroptosis.	Nat Commun. 2024 Oct 17;15(1):8971.
4T1 cells	2.9 μM	24 h	CuP/Er enhances ferroptosis via ROS generation, lipid peroxidation, and GSH depletion, and induces cuproptosis, leading to mitochondrial dysfunction and irreparable mitochondrial damage.	Adv Sci (Weinh). 2024 Jun;11(23):e2310309.
Mouse lung epithelial (MLE-2) cells	10 μM	24 h	To investigate the effect of Erastin on hypoxia/reoxygenation (HR)-induced acute lung injury (ALI) and ferroptosis. Results showed that Erastin significantly increased the expression of ferroptosis-related proteins in HR-induced MLE-2 cells, and liproxstatin-1 reversed this effect.	Cell Death Differ. 2020 Sep;27(9):2635-2650.
HT-1080 cells	5 μM	6 h	To evaluate the effect of Erastin on glutathione (GSH) levels, results showed that Erastin significantly reduced intracellular GSH levels, indicating it induces ferroptosis by inhibiting system xc−.	Nat Chem Biol. 2018 May;14(5):507-515.
HT-1080 cells	10 μM	6 h	To evaluate the lipid peroxidation induced by Erastin and FINO 2, results showed that both Erastin and FINO 2 increased the fluorescence intensity of C-11 BODIPY, indicating they induced lipid peroxidation, with FINO 2 showing a stronger effect.	Nat Chem Biol. 2018 May;14(5):507-515.

BALB/c nude mice	Cholangiocarcinoma xenograft model	Intraperitoneal injection	15 mg/kg	Once every 2 days, total of 10 times, lasting 20 days	To evaluate the effect of IDH1 mutation on erastin-induced tumor growth inhibition in cholangiocarcinoma, results showed that IDH1 mutation promoted the tumor-suppressive effect of erastin	Open Med (Wars). 2022 May 6;17(1):863-870
BALB/c nude mice	Cholangiocarcinoma xenograft model	Intraperitoneal injection	15 mg/kg	Once every 2 days, a total of 10 times, for 20 days	To investigate the effect of IDH1 mutation on erastin-induced tumor growth inhibition in cholangiocarcinoma, results showed that IDH1 mutation promoted erastin-induced tumor growth inhibition	Open Med (Wars). 2022 May 6;17(1):863-870
NSG (NOD-SCID-IL2R γ) male mice	DU145, ARCaP, PC3, H660 prostate cancer xenograft models	Intraperitoneal injection	20 mg/kg	Once daily	To evaluate the effect of Erastin on prostate cancer xenograft tumor growth, results showed that Erastin significantly delayed tumor growth.	Cancer Res. 2021 Mar 15;81(6):1583-1594.
Nude mice	Subcutaneous transplantation of IOMM-Lee cells	Intraperitoneal injection	15 mg/kg	Twice every other day for 35 days	Erastin slowed tumor growth rate, and MEF2C knockdown further enhanced the tumor inhibition effect of Erastin. NF2 or E-cadherin overexpression restored the growth of Erastin-treated shMEF2C 1# IOMM-Lee tumors.	Neuro Oncol. 2021 Dec 1;23(12):2014-2027.
Nude mice	Subcutaneous melanoma model	Intraperitoneal injection	15 mg/kg	Twice every other day for 20 days	To investigate the effect of Nedd4 knockdown on Erastin-induced ferroptosis in melanoma cells, it was found that Nedd4 knockdown significantly enhanced Erastin-induced tumor reduction and ferroptosis.	Nat Commun. 2020 Jan 23;11(1):433.
Nude mice	OS-RC-2 tumor model	Intraperitoneal injection	40 mg/kg	Every other day for 12 days	To study the synergistic effect of IKE and SAM on tumor growth suppression, results showed that SAM enhanced the inhibitory effect of IKE.	Nat Commun. 2024 Oct 17;15(1):8971.
Mice	MC38 colon cancer model	Intravenous injection	30 mg/kg	Once every three days for a total of three doses	CuP/Er significantly inhibits tumor growth by inducing ferroptosis and cuproptosis, and further enhances the antitumor effect when combined with an anti-PD-L1 antibody, preventing tumor metastasis.	Adv Sci (Weinh). 2024 Jun;11(23):e2310309.
Mice	Intestinal ischemia/reperfusion (I/R)-induced acute lung injury (ALI) model	Tail vein injection	10 μM	Daily for 20 days	To investigate the effect of Erastin on intestinal ischemia/reperfusion (I/R)-induced acute lung injury (ALI) and ferroptosis. Results showed that Erastin significantly increased oxidative stress markers (MDA, Fe2+) and decreased GSH levels in I/R mice, and liproxstatin-1 reversed this effect.	Cell Death Differ. 2020 Sep;27(9):2635-2650.

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CAS No.: 571203-78-6

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CAS No.: 571203-78-6

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed